A5010135314- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Hepatitis C virus research
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- CAR-T cell therapy research
- Systemic Lupus Erythematosus Research
- Head and Neck Cancer Studies
- Genomics and Rare Diseases
- Gastrointestinal disorders and treatments
- Lung Cancer Treatments and Mutations
- Tumors and Oncological Cases
- Genomics and Phylogenetic Studies
- Cardiac tumors and thrombi
- Cancer-related gene regulation
- Diabetes and associated disorders
- T-cell and Retrovirus Studies
Uppsala University
2023
Science for Life Laboratory
2023
Centro di Riferimento Oncologico
2008-2021
Center for Translational Molecular Medicine
2021
National Cancer Institute
2010-2015
National Institutes of Health
2011
Ospedali Riuniti di Ancona
2007
Istituti di Ricovero e Cura a Carattere Scientifico
2002-2006
University of Udine
2000
University of Trieste
1990
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of gastrointestinal tract. The vast majority GISTs driven by oncogenic activation KIT, PDGFRA or, less commonly, BRAF. Loss succinate dehydrogenase complex activity has been identified in subsets KIT/PDGFRA/BRAF-mutation negative tumours, yet a significant fraction devoid any such alterations. To address pathobiology these 'quadruple-negative' GISTs, we sought to explore possible involvement fusion genes. this...
Although Gastrointestinal stromal tumors (GISTs) affect about 0.0014% of the population, GISTs smaller than 1 cm (microGISTs) are detectable in 20% to 30% elderly individuals. This suggests that microGISTs likely represent premalignant precursors evolve only a minute fraction cases toward overt GISTs. We sought histopathologic and molecular explanations for infrequent clinical progression small To investigate mechanisms GIST identify subsets with differential malignant potential, we carried...
The tumor-suppressor protein p53 is over-expressed in a large fraction of squamous-cell carcinomas the larynx (LSCCs). overexpression dependent upon synthesis mutated versions and has been associated with malignant progression certain tumor types. In order to examine prognostic value immunodetection LSCCs, we performed retrospective analysis on selected series tumors, using PAb 1801 CM1 antibodies. No significant difference frequency over-expression was observed between tumors from patients...
The majority of gastrointestinal stromal tumors (GIST) are driven by KIT, PDGFRA, or, less commonly, BRAF mutations, and SDH gene inactivation is involved in a limited fraction gastric lesions. However, about 10% GISTs devoid any such alterations poorly responsive to standard treatments. This study aims shed light on the molecular drivers quadruple-negative GISTs.Twenty-two sporadic with no prior association Neurofibromatosis Type 1 syndrome were molecularly profiled for panel genes...
The mutation status of KIT or PDGFRA notoriously affects the response advanced gastrointestinal stromal tumors (GISTs) to tyrosine kinase inhibitors. Conversely, it is currently still unclear whether impinges on prognosis localized, untreated GISTs. Hence, at present, this variable not included in decision making for adjuvant therapy. A series 451 primary localized GISTs were analyzed KIT, PDGFRA, and BRAF mutations. Univariable multivariable analyses a backward selection procedure used...
Objective Type II mixed cryoglobulinemia (type MC) is often characterized by features of indolent B cell lymphoma (IBCL) found on pathologic examination bone marrow, whereas the clinical evidence does not indicate a neoplastic disorder. To better address issue malignant versus nonmalignant marrow lymphoproliferation underlying type MC, molecular analyses clonality were performed in present study, conjunction with and characterization. Methods Polymerase chain reaction DNA amplification...
Type II mixed cryoglobulinemia (MC) is a systemic vasculitis characterized by the presence in serum of monoclonal cryoprecipitable IgM with rheumatoid factor (RF) activity. Hepatitis C virus (HCV) has been recognized as its major etiologic factor. Because MC frequently evolves into overt B-cell non-Hodgkin's lymphoma (NHL), chronic HCV infection hypothesized to lead both benign and malignant lymphoproliferative disease. In this study, we investigated mutations V(H) V(K) genes clone...
Sjögren's syndrome (SS) represents a pathological model of the evolution from polyclonal B lymphocyte activation to oligoclonal / monoclonal cell expansion, which may culminate in development malignant lymphoproliferative disease. The different phases this process are usually marked by appearance antigen-driven activated clones, commonly IgM-positiveand with rheumatoid factor (RF) activity. However, agent(s) able trigger proliferation is still unknown. A similar pathogenetic mechanism exist...
The hepatitis C virus (HCV) has been linked to B-cell lymphoproliferation and autoimmunity, localized in several tissues. clinical observation of an HCV-infected patient with Sjögren’s syndrome (SS) Helicobacter pylori (HP) positive gastric low-grade non-Hodgkin’s lymphoma (NHL), which did not regress after HP eradication, led us investigate the possible localization HVC microenvironment. HCV genome antigens were searched biopsy specimens from previously mentioned case, as well 9 additional...
Gastrointestinal stromal tumors (GIST) are commonly regarded as solitary tumors. The occurrence of multiple lesions is considered an extraordinary event restricted to pediatric GISTs and rare hereditary conditions. Beyond these well-defined situations, the presentation synchronous viewed result metastatic spreading a single primary GIST. Based on this axiom, patients with multifocal disease classified advanced stage treated such. Whether, indeed, detection several in sporadic adult GIST may...
Daniela Gasparotto 1 , Jerry Polesel 2 Alessandra Marzotto Roberta Colladel Sara Piccinin Piergiorgio Modena Grizzo Sandro Sulfaro 3 Diego Serraino Luigi Barzan 4 Claudio Doglioni 5 and Maestro Unit of Experimental Oncology 1, CRO National Cancer Institute, Aviano, Italy Epidemiology Biostatistics, Pathology, Pordenone City Hospital, Pordenone, Otorhinolaryngology, San Raffaele Milano, Received: December 19, 2011; Accepted: 20, Published: 22, Keywords: TWIST1, TWIST2, SNAI1, SNAI2, EMT,...
Abstract With the rapid advancement of sequencing technologies, next generation (NGS) analysis has been widely applied in cancer genomics research. More recently, NGS adopted clinical oncology to advance personalized medicine. Clinical applications precision require accurate tests that can distinguish tumor-specific mutations from artifacts introduced during processes or data analysis. Therefore, there is an urgent need develop best practices mutation detection using and for standard...
The p16/CDKN2 (MTSI) gene encoding for the p16 inhibitor of cyclin D/CDK4 complexes is frequently mutated and deleted in a large fraction melanoma cell lines, germline mutations have also been observed familial melanomas. Moreover, CDK4 mutation, responsible functional resistance kinase to inhibitory activity, has described occur some cases melanoma. These data strongly support idea that deregulation CDK4/cyclin D pathway, via CDKN2 or mutations, biological significance development To shed...
// Sabrina Rossi 1 , Marta Sbaraglia Campo Dell'Orto Daniela Gasparotto 2 Matilde Cacciatore Elena Boscato Valentina Carraro Luisa Toffolatti Giovanna Gallina Monia Niero Emanuela Pilozzi 3 Alessandra Mandolesi 4 Fausto Sessa 5 Aurelio Sonzogni 6 Cristina Mancini 7 Guido Mazzoleni 8 Salvatore Romeo Roberta Maestro 2,* and Angelo P. Dei Tos 1,* Department of Pathology Molecular Genetics, Treviso General Hospital, Treviso, Italy Experimental Oncology, CRO, Aviano, Clinical Medicine, University...