A5013215092- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Soft tissue tumor case studies
- Gastrointestinal disorders and treatments
- Chromatin Remodeling and Cancer
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
- Gastric Cancer Management and Outcomes
- Tumors and Oncological Cases
- Radiomics and Machine Learning in Medical Imaging
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- Soft tissue tumors and treatment
- Neuroblastoma Research and Treatments
- Cancer Research and Treatments
- Vascular Tumors and Angiosarcomas
- Cell Adhesion Molecules Research
- Meningioma and schwannoma management
- Renal cell carcinoma treatment
Bambino Gesù Children's Hospital
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2025
Ca' Foncello Hospital
2012-2022
University of Ferrara
2021
IRCCS Humanitas Research Hospital
2021
Fondazione Humanitas per la Ricerca
2018
Hôpital des Enfants
2014
Deakin University
2014
University Hospital Augsburg
2014
University Hospital Münster
2014
Atypical teratoid/rhabdoid tumors (AT/RTs) are highly aggressive brain of early childhood poorly responding to therapy. The majority cases show inactivation SMARCB1 (INI1, hSNF5, BAF47), a core member the adenosine triphosphate (ATP)-dependent SWI/SNF chromatin-remodeling complex. We here report case supratentorial AT/RT in 9-month-old boy, which showed retained staining on immunohistochemistry and lacked genetic alterations SMARCB1. Instead, tumor loss protein expression another complex...
Abstract Purpose: Angiomatoid fibrous histiocytoma (AFH) is a low-grade mesenchymal neoplasm which usually occurs in children and adolescents. Either FUS-ATF1 or EWSR1-ATF1 have been detected the few cases published, pointing to interchangeable role of FUS EWSR1 this entity. also represents most frequent genetic alteration clear cell sarcoma, suggesting existence molecular homology between these two histotypes. We investigated presence EWSR1-CREB1, recently found gastrointestinal FUS-CREB1,...
Novelli M, Rossi S, Rodriguez‐Justo Taniere P, Seddon B, Toffolatti L, Sartor C, Hogendoorn P C W, Sciot R, Van Glabbeke Verweij J, Blay J Y, Hohenberger Flanagan A & Dei Tos (2010) Histopathology 57 , 259–270 DOG1 and CD117 are the antibodies of choice in diagnosis gastrointestinal stromal tumours Aims: The histopathological (GIST) is typically made based on a combination clinical morphological features supported by immunohistochemistry studies. aim this study was to examine staining...
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of gastrointestinal tract. The vast majority GISTs driven by oncogenic activation KIT, PDGFRA or, less commonly, BRAF. Loss succinate dehydrogenase complex activity has been identified in subsets KIT/PDGFRA/BRAF-mutation negative tumours, yet a significant fraction devoid any such alterations. To address pathobiology these 'quadruple-negative' GISTs, we sought to explore possible involvement fusion genes. this...
Although Gastrointestinal stromal tumors (GISTs) affect about 0.0014% of the population, GISTs smaller than 1 cm (microGISTs) are detectable in 20% to 30% elderly individuals. This suggests that microGISTs likely represent premalignant precursors evolve only a minute fraction cases toward overt GISTs. We sought histopathologic and molecular explanations for infrequent clinical progression small To investigate mechanisms GIST identify subsets with differential malignant potential, we carried...
Gastrointestinal stromal tumor (GIST) natural history per se has not been extensively investigated yet, with most data being drawn from large studies a relevant referral bias. Hence, the estimation of prognosis still remains critical issue. We retrospectively evaluated 929 GISTs resected between 1980 and 2000 in 35 Italian institutions. A total 526 patients were found to be suitable for refining risk assessment through development survival nomogram. Median follow-up was 126 months. On...
Rabbit monoclonal antibodies (RabMAbs) represent a novel category of immunoreagents that may combine the best properties both mouse (MMAs) and rabbit antisera. In attempt to verify performance this new class on paraffin-embedded tissue, RabMAbs against estrogen receptor, progesterone Ki-67, cyclin D1, CD3, CD5, CD23, synaptophysin were tested several tumor types as well normal tissues. The results compared with those obtained classic MMAs same antigens. appear offer increased sensitivity no...
The majority of gastrointestinal stromal tumors (GIST) are driven by KIT, PDGFRA, or, less commonly, BRAF mutations, and SDH gene inactivation is involved in a limited fraction gastric lesions. However, about 10% GISTs devoid any such alterations poorly responsive to standard treatments. This study aims shed light on the molecular drivers quadruple-negative GISTs.Twenty-two sporadic with no prior association Neurofibromatosis Type 1 syndrome were molecularly profiled for panel genes...
// Erica Lorenzetto 1 , Monica Brenca Mattia Boeri 2 Carla Verri Elena Piccinin Patrizia Gasparini Federica Facchinetti Sabrina Rossi 3 Giuliana Salvatore 4 Maura Massimino 5 Gabriella Sozzi Roberta Maestro Piergiorgio Modena 6 Experimental Oncology 1, Aviano National Cancer Institute, (PN), Italy. Tumor Genomics Laboratory, Milan Milan, Department of Pathology, Treviso General Hospital, Treviso, Biology and Cellular Molecular University Federico II, Naples, Unit Pediatric Oncology,...
Meningeal solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) is a rare with propensity for recurrence and metastasis. Although multiple classification schemes have been proposed, optimal risk stratification remains unclear, the prognostic impact of fusion status uncertain. We compared 2016 WHO CNS grading scheme (CNS-G), three-tier system based on histopathologic phenotype mitotic count, to 2013 soft-tissue counterpart (ST-G), two-tier count alone, in cohort 133 patients [59 female, 74...
Hobnail variant of papillary thyroid carcinoma (HPTC) represents a recently described, aggressive and rare group tumors with poorly understood pathogenesis. Molecular data about this cancers are few, more detailed molecular characterization these is needed. The main objective the study to define comprehensive typing HPTC. Eighteen patients affected by HPTC, including eighteen primary four lymph node metastases, were screened for NRAS, KRAS, HRAS, BRAF, TP53, PIK3CA, hTERT, PTEN, CDKN2A,...
The mutation status of KIT or PDGFRA notoriously affects the response advanced gastrointestinal stromal tumors (GISTs) to tyrosine kinase inhibitors. Conversely, it is currently still unclear whether impinges on prognosis localized, untreated GISTs. Hence, at present, this variable not included in decision making for adjuvant therapy. A series 451 primary localized GISTs were analyzed KIT, PDGFRA, and BRAF mutations. Univariable multivariable analyses a backward selection procedure used...
Malignant change in a benign vascular tumor is exceedingly rare, and there have been only five previously reported convincing cases. Four new cases of angiosarcoma (AS) arising hemangioma/vascular malformation (HVM) are described. All patients were the 6th or 7th decade life (two female, two male). Development an enlarging deep-seated mass was main presenting symptom. MRI disclosed presence separate soft tissue masses both thighs one patient. No patient had history prior radiotherapy at same...
Rabbit monoclonal antibodies (RabMAbs) represent a novel category of immunoreagents that may combine the best properties both mouse (MMAs) and rabbit antisera. In attempt to verify performance this new class on paraffin-embedded tissue, RabMAbs against estrogen receptor, progesterone Ki-67, cyclin D1, CD3, CD5, CD23, synaptophysin were tested several tumor types as well normal tissues. The results compared with those obtained classic MMAs same antigens. appear offer increased sensitivity no...
Gastrointestinal stromal tumors (GIST) are commonly regarded as solitary tumors. The occurrence of multiple lesions is considered an extraordinary event restricted to pediatric GISTs and rare hereditary conditions. Beyond these well-defined situations, the presentation synchronous viewed result metastatic spreading a single primary GIST. Based on this axiom, patients with multifocal disease classified advanced stage treated such. Whether, indeed, detection several in sporadic adult GIST may...
The MEF2-class IIa histone deacetylase (HDAC) axis operates in several differentiation pathways and numerous adaptive responses. We show here that nuclear active HDAC4 HDAC7 display transforming capability. oncogenic potential depends on the repression of a limited set genes, most which are MEF2 targets. Genes verified as targets MEF2-HDAC also under influence phosphatidylinositol 3-kinase (PI3K)/Akt pathway affects protein stability. A signature target genes identified by this study is...
Recently a few cases of synovial sarcoma (SS) the abdominal viscera have been reported, raising awareness about potential for confusion between this entity and KIT-negative gastrointestinal stromal tumors (GIST). We report clinicopathological, immunophenotypical molecular features fifteen more SS occurring in stomach (8 cases), epigastric region (one case), small intestine large (three involving both terminal ileum caecum case) liver case).Immunostains SMA, DESMIN, CD34, CD117, S100, EMA, CK...
Epithelioid sarcoma is a rare soft tissue neoplasm that usually arises in the distal extremities of young adults. presents high rate recurrences and metastases frequently poses diagnostic dilemmas. We previously reported loss tumor suppressor SMARCB1 protein expression gene deletion majority epithelioid cases. Unfortunately, no appropriate preclinical models such genetic alteration are available. In present report, we identified lack due to homozygous exon 1 upstream regulatory region cell...
The contribution of MEF2 TFs to the tumorigenic process is still mysterious. Here we clarify that can support both pro-oncogenic or tumor suppressive activities depending on interaction with co-activators co-repressors partners. Through these interactions supervise histone modifications associated gene activation/repression, such as H3K4 methylation and H3K27 acetylation. Critical switches for generation a repressive environment are class IIa HDACs. In leiomyosarcomas (LMS), this two-faced...