A5055187834- Cutaneous Melanoma Detection and Management
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Melanoma and MAPK Pathways
- Metastasis and carcinoma case studies
- Nonmelanoma Skin Cancer Studies
- Vascular Tumors and Angiosarcomas
- Immunotherapy and Immune Responses
- Cutaneous lymphoproliferative disorders research
- Bone Tumor Diagnosis and Treatments
- Allergic Rhinitis and Sensitization
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Computational Drug Discovery Methods
- Cancer Genomics and Diagnostics
- Soft tissue tumor case studies
- Cell Adhesion Molecules Research
- Optical Coherence Tomography Applications
- CAR-T cell therapy research
- Cancer and Skin Lesions
- Breast Cancer Treatment Studies
- Lymphoma Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- AI in cancer detection
Istituto Oncologico Veneto
2012-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2021
University of Padua
2006-2015
The objectives of this study were to measure the incidence sarcomas, including viscerally sited tumors that are not reported in cancer statistics, and draw explanatory clues from a large reliable sarcoma data set.Cases sarcomas regardless primary site (except bone joints) collected during 2 years 3 European regions totaling approximately 26,000,000 person-years. sources used pathology reports hospital discharges forms. Diagnoses reviewed by expert pathologists classified according 2002 World...
Current clinical and histopathological criteria used to define the prognosis of melanoma patients are inadequate for accurate prediction outcome. We investigated whether genome screening by means high-throughput gene microarray might provide clinically useful information on patient survival.Forty-three tumor tissues from 38 with stage III IV were profiled a 17,500 element cDNA microarray. Expression data analyzed using significance analysis microarrays (SAM) identify genes associated...
To evaluate the efficacy of preoperative ultrasound (US) scanning in identifying lymph node metastasis before sentinel biopsy (SNB), we conducted a prospective study on 125 patients with primary cutaneous melanoma (CM).We prospectively enrolled >1 mm thick CM and candidate for SNB. Preoperatively, underwent US regional lymphatic basins FNA suspected nodes (LN). All mapping SNB.Combined fine-needle aspirate (FNA) suspect LN, scan allowed correct detection 12 out 31 histologically positive...
Photopheresis (ECP) is a new type of photochemotherapy, used for the treatment oncological and autoimmune diseases. Lymphocytes are drawn from patients by leukapheresis, treated with 8‐methoxypsoralen (8‐MOP) ultraviolet light A (UVA) in an extracorporeal system then reinfused. Skin exposure to 8‐MOP UVA (PUVA) has been shown relieve cutaneous symptoms graft‐versus‐host disease (GVHD) bone marrow transplant (BMT) recipients. ECP, which similar some ways PUVA, this study treat four paediatric...
Sarcomas are rare, heterogenous, and often difficult to classify. A large proportion of sarcomas associated with specific molecular genetic lesions such as translocations, mutations, amplifications, which helpful in the diagnosis individual cases. However, exact impact genetics on final is unknown. In this study, all soft tissue visceral arising patients living 3 European regions 2 countries (representing 13 million inhabitants) were collected reviewed during consecutive years. analysis was...
Recently a few cases of synovial sarcoma (SS) the abdominal viscera have been reported, raising awareness about potential for confusion between this entity and KIT-negative gastrointestinal stromal tumors (GIST). We report clinicopathological, immunophenotypical molecular features fifteen more SS occurring in stomach (8 cases), epigastric region (one case), small intestine large (three involving both terminal ileum caecum case) liver case).Immunostains SMA, DESMIN, CD34, CD117, S100, EMA, CK...
Abstract Perivascular epithelioid cell tumors (PEComas) are rare soft-tissue with an extremely heterogeneous clinical behavior. They may arise in different organs and behave indolently or sometimes metastasize grades of biological aggressiveness. We report the case a young woman primary inoperable PEComa liver malignant histological features. Since mTOR pathway is often altered PEComas responses have been reported mTOR-inhibitors such as sirolimus temsirolimus, we decided to start...
Aim: To establish the accuracy of magnetic resonance imaging (MRI) in distinguishing between benign and malignant lipomatous tumors; to evaluate reproducibility MRI interpretation assessing agreement judgments two radiologists with same experience soft-tissue sarcomas; identify an association among findings (size, depth, septa, nodules, signal homogeneity) nature lesion. Materials Methods: A total 54 patients (28 men 26 women), a mean age 56 (range=27-84) were included years. All subjects...
Cutaneous melanoma is a major concern in terms of healthcare systems and economics. The aim this study was to estimate the direct costs by disease stage, phase diagnosis, treatment according pre-set clinical guidelines drafted AIOM (Italian Medical Oncological Association). Based on for malignant cutaneous melanoma, highly detailed decision-making model developed describing patient?s pathway from diagnosis through subsequent phases staging, surgical medical treatment, follow-up. associates...
Abstract Metastatic melanoma is characterized by complex genomic alterations, including a high rate of mutations in driver genes and widespread deletions amplifications encompassing various chromosome regions. Among them, 7 frequently gained BRAF-mutant melanoma, inducing mutant allele–specific imbalance. Although BRAF amplification known mechanism acquired resistance to therapy with MAPK inhibitors, it still unclear if copy-number variation allele imbalance at baseline can be associated...
Abstract Background Sarcomas are rare tumors (1-2% of all cancers) mesenchymal origin that may develop in soft tissues and viscera. Since the International Classification Disease (ICD) attributes visceral sarcomas (VS) to organ origin, incidence sarcoma is grossly underestimated. The rarity disease variety histological types (more than 70) or locations account for difficulty acquiring sufficient personal experience. In view above European Commission funded project called Connective Tissues...
Thyroid carcinomas display several pathologic features, show different behavior and necessitate treatment; thus correct classification is mandatory.The kappa statistic was used as a measure of agreement in panel seven pathologists who reviewed 200 cases thyroid tumors.Overall 83% (k = 68). Good found for anaplastic 0.85) papillary 0.81); medullary carcinoma acceptable 0.80), suboptimal other 0.67), poor follicular 0.54).Central pathology review recommended when clinical epidemiologic trials...