A5077513353- Pediatric Urology and Nephrology Studies
- Renal Diseases and Glomerulopathies
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Dialysis and Renal Disease Management
- Kidney Stones and Urolithiasis Treatments
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Erythropoietin and Anemia Treatment
- Renal and Vascular Pathologies
- Neonatal Health and Biochemistry
- Metabolism and Genetic Disorders
- Electrolyte and hormonal disorders
- Iron Metabolism and Disorders
- Biomedical Research and Pathophysiology
- Ion Transport and Channel Regulation
- COVID-19 Clinical Research Studies
- Complement system in diseases
- Renal Transplantation Outcomes and Treatments
- Adolescent and Pediatric Healthcare
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Escherichia coli research studies
- Coenzyme Q10 studies and effects
- Pharmacological Effects and Toxicity Studies
- Acute Kidney Injury Research
University of Milan
2016-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016-2025
University of Palermo
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2023
Hacettepe University
2023
University of Genoa
2023
Istituto Giannina Gaslini
2023
Morgan Stanley Children's Hospital
2023
University of Milano-Bicocca
2023
Ospedale Maggiore
1999-2022
OBJECTIVES. Febrile urinary tract infections are common in children and associated with the risk for renal scarring long-term complications. Antimicrobial prophylaxis has been used to reduce recurrence. We performed a study determine whether no is similar antimicrobial 12 months reducing recurrence of febrile after first infection. METHODS. The was controlled, randomized, open-label, 2-armed, noninferiority trial comparing (co-trimoxazole 15 mg/kg per day or co-amoxiclav day) months. A total...
Renal hypodysplasia (RHD) is characterized by a reduced nephron number, small kidney size, and disorganized renal tissue. A hereditary basis has been established for subset of affected patients, suggesting major role developmental genes that are involved in early organogenesis. Gene mutations have dominant inheritance cause RHD, urinary tract anomalies, defined extrarenal symptoms identified TCF2 (renal cysts diabetes syndrome), PAX2 (renal-coloboma EYA1 SIX1 (branchio-oto-renal SALL1...
Primary coenzyme Q(10) (CoQ(10)) deficiency includes a group of rare autosomal recessive disorders primarily characterized by neurological and muscular symptoms. Rarely, glomerular involvement has been reported. The COQ2 gene encodes the para-hydroxybenzoate-polyprenyl-transferase enzyme CoQ(10) synthesis pathway. We identified two patients with early-onset lesions that harbored mutations in gene. first patient presented steroid-resistant nephrotic syndrome at age 18 months as result...
The efficacy of continuous antibiotic prophylaxis in preventing urinary tract infection (UTI) infants with grade III, IV, or V vesicoureteral reflux is controversial. Download a PDF the Research Summary. In this investigator-initiated, randomized, open-label trial performed 39 European centers, we randomly assigned 1 to 5 months age and no previous UTIs receive (prophylaxis group) treatment (untreated for 24 months. primary outcome was occurrence first UTI during period. Secondary outcomes...
<b>Objective</b> To compare the efficacy of oral antibiotic treatment alone with started parenterally and completed orally in children a first episode acute pyelonephritis. <b>Design</b> Multicentre, randomised controlled, open labelled, parallel group, non-inferiority trial. <b>Setting</b> 28 paediatric units north east Italy. <b>Participants</b> 502 aged 1 month to <7 years clinical <b>Intervention</b> Oral co-amoxiclav (50 mg/kg/day three doses for 10 days) or parenteral ceftriaxone...
Coenzyme Q10 (CoQ10) deficiency has been associated with various clinical phenotypes, including an infantile multisystem disorder. The authors report a 33-month-old boy who presented corticosteroid-resistant nephrotic syndrome in whom progressive encephalomyopathy later developed. CoQ10 was decreased both muscle and fibroblasts. Oral improved the neurologic picture but not renal dysfunction.
Abstract The mean annual incidence of hemolytic uremic syndrome in persons <15 years age Italy from 1988 to 2000 was 0.28 per 100,000 population. Laboratory investigations showed that Shiga toxin–producing Escherichia coli (STEC) infection occurred 73.1% patients. STEC O157 the most common serotype, but a considerable number cases were infections by non-O157 STEC.
We report the recommendations for diagnosis, treatment, imaging evaluation and use of antibiotic prophylaxis in children with first febrile urinary tract infection, aged 2 months to 3 years. They were prepared by a working group Italian Society Pediatric Nephrology after careful review available literature consensus decision, when clear evidence was not available.These are endorsed Nephrology. can also be tool comparison other existing guidelines issues which much controversy still exists.
Steroid-dependent nephrotic syndrome (SDNS) carries a high risk of toxicity from steroids or steroid-sparing agents. This open-label, noninferiority, randomized controlled trial at four sites in Italy tested whether rituximab is noninferior to maintaining remission juvenile SDNS. We enrolled children age 1-16 years who had developed SDNS the previous 6-12 months and were maintained with prednisone doses (≥0.7 mg/kg per day). randomly assigned participants continue alone for 1 month (control)...
OBJECTIVES. The American Academy of Pediatrics recommendation for febrile infants and young children suspected having a urinary tract infection is early antibiotic treatment, given parenterally if necessary. In support this recommendation, data suggesting that delay in treatment acute pyelonephritis increases the risk kidney damage are cited. Because was not well defined, we investigated renal scarring associated with delayed versus children. METHODS. research findings derived from 2...
OBJECTIVE: To evaluate the yield, economic, and radiation costs of 5 diagnostic algorithms compared with a protocol where all tests are performed (ultrasonography scan, cystography, late technetium99dimercaptosuccinic acid scan) in children after first febrile urinary tract infections. METHODS: A total 304 children, 2 to 36 months age, who completed follow-up (ultrasonography, cystourethrography, acute scans) randomized controlled trial (Italian Renal Infection Study 1) were eligible. The...