A5067214322- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Dialysis and Renal Disease Management
- Renal function and acid-base balance
- Cardiovascular Health and Disease Prevention
- Renal and related cancers
- Biomedical Research and Pathophysiology
- Pediatric Urology and Nephrology Studies
- Sodium Intake and Health
- Neonatal Health and Biochemistry
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Genetic and Kidney Cyst Diseases
- Parathyroid Disorders and Treatments
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Renal and Vascular Pathologies
- Electrolyte and hormonal disorders
- Hormonal Regulation and Hypertension
- Metabolism and Genetic Disorders
- Obesity, Physical Activity, Diet
- Renal Transplantation Outcomes and Treatments
- Genetic Syndromes and Imprinting
- Cardiovascular Function and Risk Factors
- Ion Transport and Channel Regulation
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
German Center for Pediatric and Adolescent Rheumatology
2010-2024
Heidelberg University
2006-2024
RELX Group (United States)
2022
Ege University
2020
University Medical Center Groningen
2020
University of Groningen
2020
KU Leuven
2019
Society of Interventional Radiology
2018
Increasing prevalence of hypertension (HTN) in children and adolescents has become a significant public health issue driving considerable amount research. Aspects discussed this document include advances the definition HTN 16 year or older, clinical significance isolated systolic youth, importance out office central blood pressure measurement, new risk factors for HTN, methods to assess vascular phenotypes, clustering cardiovascular treatment strategies among others. The recommendations...
Background Twenty-four-hour ambulatory blood pressure monitoring (ABPM) is an essential tool in the diagnosis and therapeutic of arterial hypertension children. The statistical use pediatric ABPM reference values has been compromised by non-Gaussian distribution 24-h (BP) Objective To develop distribution-adjusted tables. Methods From cross-sectional data obtained 949 healthy children adolescents aged 5–20 years, a set tables was developed for 24-h, daytime night-time mean systolic,...
Hypertension in children and adolescents has gained ground cardiovascular medicine, thanks to the progress made several areas of pathophysiological clinical research. These guidelines represent a consensus among specialists involved detection control high blood pressure adolescents. The synthesize considerable amount scientific data experience best wisdom upon which physicians, nurses families should base their decisions. They call attention burden hypertension adolescents, its contribution...
Congenital nephrotic syndrome (CNS) is clinically and genetically heterogeneous, with mutations in WT1, NPHS1 NPHS2 accounting for part of cases. We recently delineated a new autosomal recessive entity comprising CNS diffuse mesangial sclerosis distinct ocular anomalies microcoria as the leading clinical feature (Pierson syndrome). On basis homozygosity mapping to markers on chromosome 3p14-p22, we identified homozygous or compound heterozygous LAMB2 patients from five unrelated families....
Objective Sonographic evaluation of arterial wall morphology and elasticity is increasingly accepted as a non-invasive tool in cardiovascular assessment. Several studies suggest that intima–media thickness (IMT) indices may sensitively reflect different vasculopathic processes children. However, normative values the impact adolescent growth are largely unknown. Methods We assessed IMT common carotid (cIMT) femoral arteries (fIMT), interacting anthropometric factors 247 healthy subjects aged...
Renal hypodysplasia (RHD) is characterized by a reduced nephron number, small kidney size, and disorganized renal tissue. A hereditary basis has been established for subset of affected patients, suggesting major role developmental genes that are involved in early organogenesis. Gene mutations have dominant inheritance cause RHD, urinary tract anomalies, defined extrarenal symptoms identified TCF2 (renal cysts diabetes syndrome), PAX2 (renal-coloboma EYA1 SIX1 (branchio-oto-renal SALL1...
Carotid intima-media thickness (cIMT) and carotid artery distensibility are reliable screening methods for vascular alterations the assessment of cardiovascular risk in adult pediatric cohorts. We sought to establish an international reference data set childhood adolescence period explore impact developmental changes body dimensions blood pressure (BP) on wall elasticity. cIMT, coefficient, incremental modulus elasticity, stiffness index β were assessed 1155 children aged 6 18 years...
Congenital anomalies of the kidney and urinary tract (CAKUT) are leading cause ESRD in children, but proportion patients with individual CAKUT entities progressing to during adulthood their long-term clinical outcomes unknown. This study assessed age at onset renal replacement therapy (RRT) patient graft survival across entire range.Patients were compared age-matched who undergoing RRT for other disorders on basis data from European Renal Association-European Dialysis Transplant Association...
Cystinosis is caused by mutations in the CTNS gene (17p13.2), which encodes for a lysosomal cystine/proton symporter termed cystinosin. It most common cause of inherited renal Fanconi syndrome young children. Because its rarity, diagnosis and specific treatment cystinosis are frequently delayed, has significant impact on overall prognosis. In this document, we have summarized expert opinions several aspects disease to improve knowledge provide guidance treatment.
Growth hormone treatment stimulates growth in short children with chronic renal failure. However, the extent to which this therapy increases final adult height is not known.
Left ventricular hypertrophy (LVH) is the most important independent marker of cardiovascular risk in adults with chronic kidney disease. Cardiovascular morbidity seems increased even children renal insufficiency (CRI), but age and stage CRI when cardiac alterations become manifest are unknown. For assessing prevalence factors associated abnormal LV geometry CRI, echocardiograms, ambulatory BP monitoring, biochemical profiles were obtained 156 aged 3 to 18 yr stages 2 through 4 disease (GFR...
Background and objectives Cardiovascular disease is the most important comorbidity affecting long-term survival in children with CKD. Design, setting, participants, & measurements The Comorbidity Children CKD Study a multicenter, prospective, observational study ages 6–17 years old initial GFR of 10–60 ml/min per 1.73 m 2 . cardiovascular status monitored annually, subclinical assessed by noninvasive surrogate markers, including left ventricular mass index, carotid intima-media...
Hypertension is the leading risk factor for cardiovascular disease. Although accumulating evidence suggests tracking of blood pressure from childhood into adult life, there little information regarding relative contributions genetic, prenatal, biological, behavioral, environmental, and social determinants to pressure.Blood an array potential anthropometric, familial factors high pressure, including parental smoking habits, were determined as part a screening project in 4236 preschool...
Children and adolescents with chronic kidney disease (CKD) are at high risk for cardiovascular morbidity mortality. A systemic arteriopathy cardiomyopathy has been characterized in pediatric dialysis patients by the presence of morphologic functional abnormalities.The Cardiovascular Comorbidity CKD (4C) Study is a multicenter, prospective, observational study aiming to recruit more than 600 children, aged 6 17 years, initial GFR 10 45 ml/min per 1.73 m(2). The prevalence, degree, progression...
BACKGROUND Aortic pulse wave velocity (PWV), an indicator of arterial stiffness, independently predicts cardiovascular mortality risk in adults. Arterial stiffening advances with age and seems accelerated children certain disease conditions such as chronic kidney or diabetes. The Vicorder, oscillometric device to measure PWV, has been validated children, but reference values a large pediatric cohort, association carotid stiffness influence individual family factors have not determined....
Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment long-term outcome. We contacted paediatric adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic clinical in an online form. Adequate were collected 340 patients (29 countries, female 52%). Mutation testing had been performed 206 (61%); pathogenic mutations identified 170 (83%). The median (range) presentation age...