Tomáš Seeman
A5017569254- Blood Pressure and Hypertension Studies
- Genetic and Kidney Cyst Diseases
- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Dialysis and Renal Disease Management
- Complement system in diseases
- Liver Disease and Transplantation
- Sodium Intake and Health
- Hormonal Regulation and Hypertension
- Biomedical Research and Pathophysiology
- Cardiovascular Health and Disease Prevention
- Renal function and acid-base balance
- Renal cell carcinoma treatment
- Genetic Syndromes and Imprinting
- Chronic Kidney Disease and Diabetes
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Cardiovascular Syncope and Autonomic Disorders
- Adolescent and Pediatric Healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Pregnancy and Medication Impact
- Birth, Development, and Health
Charles University
2016-2025
University of Ostrava
2023-2025
University Hospital Ostrava
2023-2024
Ludwig-Maximilians-Universität München
2020-2023
University Hospital in Motol
2012-2023
GTx (United States)
2022
St. Josefs Hospital
2022
LMU Klinikum
2020
General University Hospital in Prague
2001-2019
KU Leuven
2019
Increasing prevalence of hypertension (HTN) in children and adolescents has become a significant public health issue driving considerable amount research. Aspects discussed this document include advances the definition HTN 16 year or older, clinical significance isolated systolic youth, importance out office central blood pressure measurement, new risk factors for HTN, methods to assess vascular phenotypes, clustering cardiovascular treatment strategies among others. The recommendations...
Hypertension in children and adolescents has gained ground cardiovascular medicine, thanks to the progress made several areas of pathophysiological clinical research. These guidelines represent a consensus among specialists involved detection control high blood pressure adolescents. The synthesize considerable amount scientific data experience best wisdom upon which physicians, nurses families should base their decisions. They call attention burden hypertension adolescents, its contribution...
BackgroundIn chronic kidney disease (CKD), serum concentrations of fibroblast growth factor 23 (FGF23) increase progressively as glomerular filtration rate declines, while renal expression the FGF23 coreceptor Klotho decreases. Elevated circulating levels are strongly associated with mortality and left ventricular hypertrophy (LVH), which is a major cause cardiovascular death in CKD patients. The cardiac FGF23/FGF receptor (FGFR) system its role development LVH humans have not been addressed...
Abstract. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is an autosomal recessive tubular disorder that frequently associated progressive renal failure. The primary defect related to impaired reabsorption of magnesium calcium in the thick ascending limb Henle's loop. Mutations PCLN-1, which encodes tight junction protein paracellin-1 (claudin-16), were identified as underlying genetic defects. Comprehensive clinical data results PCLN-1 mutation analysis 25 FHHNC...
Tolvaptan slows expansion of kidney volume and function decline in adults with autosomal dominant polycystic disease (ADPKD). Progression during childhood could be treated before irreversible damage occurs, but trial data are lacking. We evaluated the safety efficacy tolvaptan children/adolescents ADPKD.
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive tubular disorder caused by CLDN16 mutations. encodes the renal tight junction protein claudin-16, which important for paracellular reabsorption of calcium magnesium in thick ascending limb Henle's loop. That FHHNC frequently associated progressive failure suggests additional roles claudin-16 maintenance integrity. An investigation 32 patients 17 different mutations was previously reported;...
Steroid-resistant focal segmental glomerulosclerosis (FSGS) often recurs after renal transplantation. In this international survey, we sought to identify genotype–phenotype correlations of recurrent FSGS. We surveyed 83 patients with childhood-onset primary FSGS who received at least one allograft and analyzed 53 these for NPHS2 mutations. The mean age diagnosis was 6.7 years, the first transplantation 13 years. recurred in 30 (36%) a median days (range, 1.5 152 days). Twenty-three second...
Background and objectives Autosomal dominant polycystic kidney disease is the most common inheritable disease, frequently thought to become symptomatic in adulthood. However, patients with autosomal may develop signs or symptoms during childhood, particular hypertension. Although ambulatory BP monitoring preferred method diagnose hypertension pediatrics, data children are limited. Design, setting, participants, & measurements Our retrospective multicenter study was conducted collect...
HNF1B gene mutations are an important cause of bilateral (cystic) dysplasia in children, complicated by chronic renal insufficiency. The clinical variability, the absence genotype-phenotype correlations, and limited long-term data render counseling affected families difficult. Longitudinal 62 children probands with genetically proven nephropathy was obtained a multicenter approach. Genetic family cascade screening performed 30/62 cases. Eighty-seven percent patients had dysplasia, 74%...
Background Autosomal dominant tubulointerstitial kidney disease caused by mucin-1 gene ( MUC1 ) mutations (ADTKD- is characterized progressive failure. Genetic evaluation for ADTKD- specifically tests a cytosine duplication that creates unique frameshift protein (MUC1fs). Our goal was to develop immunohistochemical methods detect the MUC1fs created and, possibly, other similar and identify novel in individuals with positive staining protein. Methods We performed immunostaining on urinary...
The joint statement is a synergistic action between HyperChildNET and the European Academy of Pediatrics about diagnosis management hypertension in youth, based on Society Hypertension Guidelines published 2016 with aim to improve its implementation. first most important requirement for an accurate measurement office blood pressure that currently recommended screening, diagnosis, high children adolescents. Blood levels should be screened all starting from age 3 years. In those risk factors...