A5023997822- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Birth, Development, and Health
- Chronic Kidney Disease and Diabetes
- Complement system in diseases
- Pediatric Urology and Nephrology Studies
- Vasculitis and related conditions
- Pregnancy and preeclampsia studies
- Systemic Lupus Erythematosus Research
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Renin-Angiotensin System Studies
- Pregnancy and Medication Impact
- Electrolyte and hormonal disorders
- Parathyroid Disorders and Treatments
- Muscle and Compartmental Disorders
- Renal and Vascular Pathologies
- Genetic and Kidney Cyst Diseases
- Nitric Oxide and Endothelin Effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Organ Donation and Transplantation
- Escherichia coli research studies
- Reproductive System and Pregnancy
- 3D Printing in Biomedical Research
Friedrich-Alexander-Universität Erlangen-Nürnberg
2009-2024
Universitätsklinikum Erlangen
2007-2020
Office of Adolescent Health
2017
Pediatrics and Genetics
2010-2012
Natural and Medical Sciences Institute
2010-2012
Arkana Laboratories
2010
Zero to Three
2006
In May and June 2011 the largest known outbreak of hemolytic uremic syndrome (HUS) occurred in northern Germany. Because, quite unusually, a large number adults was affected causative Escherichia coli strain, serotype O104:H4, showed an atypical virulence factor pattern, it speculated that this associated with aggressive course unfavorable prognosis also children.Retrospective analysis medical records 90 children comparison to previous sporadic case series.Median age unusually high (11.5...
The Wilms tumor suppressor gene 1 (WT1) plays an essential role in urogenital and kidney development. Genotype/phenotype correlations of WT1 mutations with renal function proteinuria have been observed world-wide cohorts nephrotic syndrome or (WT). This study analyzed mid-European patients known constitutional heterozygous WT1, including without WT. Retrospective analysis genotype, phenotype, treatment 53 mutation from all pediatric nephrology centers Germany, Austria, Switzerland performed...
The recent discovery of mutations in the gene encoding diacylglycerol kinase ε (DGKE) identified a novel pathophysiologic mechanism leading to HUS and/or MPGN. We report ten new patients from eight unrelated kindreds with DGKE nephropathy. combined these cases all previously published characterize phenotypic spectrum and outcomes this disease entity. Most presented accompanied by proteinuria, whereas subset exhibited clinical histologic patterns MPGN without TMA. also first two HUS/MPGN...
In 2011 Escherichia coli O104:H4 caused an outbreak with >800 cases of hemolytic uremic syndrome (HUS) in Germany, including 90 children. Data on the intermediate outcome children after HUS due to E. have been lacking.Follow-up data were gathered retrospectively from medical records patients who had included German Pediatric Registry during outbreak.Seventy-two 89 (81%) a median follow-up 3.0 (0.9-4.7) years. Hypertension and proteinuria present 19% 28% these patients, respectively. Of 4...
The glomerular filtration barrier (GFB) produces primary urine and is composed of a fenestrated endothelium, basement membrane (GBM), podocytes, slit diaphragm. Impairment the GFB leads to albuminuria microhematuria. GBM generated via secreted proteins from both endothelial cells podocytes supposed majorly contribute selectivity. While genetic mutations or variations components have been recently proposed be common cause diseases, pathways modifying stabilizing remain incompletely...
Summary In this paper, epidemiology, pathogenesis and typical morphological aspects of all three types membranoproliferative glomerulonephritis (MPGN), the haemolytic uraemic syndrome (HUS) as well thrombotic thrombopenic purpura (TTP) will be reviewed on light microscopical, immunohistological or immunofluorescence electron microscopical level. particular, differences in these diseases are discussed. Important recent molecular genetic insights into MPGN, atypical HUS TTP, i.e. dysregulation...
<i>Background/Aims:</i> Crucial steps in the initiation of lupus nephritis are deposition (auto-)antibodies and consequent complement activation. In spite aggressive treatment patients may develop terminal renal failure. Therefore, new strategies needed. extension to our previously published data we here analyzed potential renoprotective mechanisms bortezomib (BZ) experimental by focusing on morphological changes. <i>Methods:</i> Female NZB×NZW F1 mice lupus-like...
Aims Patients with renal failure develop cardiovascular alterations which contribute to the higher rate of cardiac death. Blockade renin angiotensin system ameliorates development such changes. It is unclear, however, what extent ACE-inhibitors can also reverse existing alterations. Therefore, we investigated effect high dose enalapril treatment on these Methods Male Sprague Dawley rats underwent subtotal nephrectomy (SNX, n = 34) or sham operation (sham, 39). Eight weeks after surgery, were...
Abstract Background Macrophages play an important role in the pathogenesis of lupus nephritis (LN), but less is known about macrophage subtypes pediatric LN. Here we compared renal inflammation LN with other inflammatory kidney diseases and assessed whether correlates clinical parameters. Methods Using immunofluorescence microscopy, analyzed biopsies from 20 patients (ISN/RPS classes II–V) controls for infiltration M1-like (CD68 + /CD206 − , CD68 /CD163 −), M2a-like (CD206 /CD68 +), M2c-like...
Nitric oxide formation is impaired in chronic renal failure. The renoprotective effects of a nonhypotensive dose HMR1766, direct activator the heme enzyme soluble guanylyl cyclase was studied comparison to an ACE-i remnant kidney model. Male Sprague-Dawley rats were subtotally nephrectomized (SNX) or sham operated (sham) and left untreated started on treatment with HMR1766 non-hypotensive doses. BP, albumin excretion parameters damage analyzed. After 12-week study, urinary significantly...
Recombinant hirudin (lepirudin) is a potent direct thrombin inhibitor that used particularly for treatment of immune-mediated heparin-induced thrombocytopenia. Because almost exclusively eliminated by the kidneys, its half-life markedly prolonged in patients with severe renal insufficiency. Therefore, these are at risk bleeding, because no antidote available. To use safely who on replacement therapy, knowledge hirudin-sieving characteristics different hemodialyzers required. Data this issue...
An association between low nephron number and subsequent development of hypertension in later life has been demonstrated. The underlying pathomechanisms are unknown, but glomerular postglomerular changes have discussed. We investigated whether such already present prehypertensive “glial cell line-derived neurotrophic growth factor” heterozygous mice (GDNF+/−) with lower number. Twenty-six-week-old [22 GDNF+/−, 29 C57B6 wild-type control (wt)] were used for vivo experiments intra-arterial...
Percutaneous renal biopsy (PRB) of kidney transplants might be prevented by an elevated risk bleeding or limited access to the allograft. In following, we describe our initial experience with 71 transvenous transplant biopsies in 53 consecutive patients unexplained reduced graft function who were considered unsuitable candidates for PRB (4.2% all at institution). Biopsies performed via ipsilateral femoral vein a set designed transjugular (TJRB) native kidneys. Positioning system within was...
Mast cells (MC) and dendritic (DC) have immune modulatory function can influence T-cell activity. Both cell types been found in atherosclerotic plaques are thought to play an important role for plaque stability. Compared matched segments of the non-renal population, patients with chronic kidney disease (CKD) show a more pronounced aggressive course atherosclerosis higher calcification significantly complications rates. It was aim this study analyze number localization MCs DCs, macrophages,...
Uremic cardiomyopathy of men and rodents is characterized by lower myocardial capillary supply that in rats could be prevented central peripheral blockade the sympathetic nervous system. The underlying pathomechanisms remain largely unknown. We investigated whether alterations cardiac vascular endothelial growth factor (VEGF) gene protein expression were involved. In our long-term experiment, we analyzed VEGF was altered heart male Sprague-Dawley with either sham operation (sham, n=10) or...