A5045970281- Blood Pressure and Hypertension Studies
- Medical Practices and Rehabilitation
- Heart Rate Variability and Autonomic Control
- Hormonal Regulation and Hypertension
- Health and Medical Studies
- Renin-Angiotensin System Studies
- Physics and Engineering Research Articles
- Medical and Health Sciences Research
- Engineering and Materials Science Studies
- Biomedical and Chemical Research
- Sodium Intake and Health
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Consumer behavior in food and health
- Renal Diseases and Glomerulopathies
- Peripheral Artery Disease Management
- Renal and Vascular Pathologies
- Metabolism and Genetic Disorders
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Chronic Kidney Disease and Diabetes
- Hematological disorders and diagnostics
- Diet and metabolism studies
- Apelin-related biomedical research
- Dialysis and Renal Disease Management
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2024
Paracelsus Medizinische Privatuniversität
2018-2024
Bayer (Germany)
2024
Universitätsklinikum Erlangen
2008-2024
Nuremberg Hospital
2020-2023
University of Oxford
2023
Goethe University Frankfurt
2001-2016
Universitätsklinikum des Saarlandes
2013-2016
Saarland University
2016
Hypertension Institute
2009-2011
Abstract Introduction Evidence from a number of open-label, uncontrolled studies has suggested that rituximab may benefit patients with autoimmune diseases who are refractory to standard-of-care. The objective this study was evaluate the safety and clinical outcomes in several standard-of-care-refractory (within rheumatology, nephrology, dermatology neurology) other than rheumatoid arthritis or non-Hodgkin's lymphoma real-life setting. Methods Patients received having shown an inadequate...
Objectives: Arterial hypertension and increased sympathetic activity are underlying pathogenetic mechanisms of the progressive loss renal function in patients with chronic kidney disease (CKD). Meta-analyses have shown that impaired is an independent cardiovascular risk factor. We hypothesized denervation (RDN) decreases decline CKD stages 3 4 treatment-resistant hypertension. Methods: performed observational study 27 4, office blood pressure (BP) ≥ 140/90 mmHg, while on at least three...
Abstract. This study tested the hypothesis that nitric oxide (NO)-mediated renal vasodilation due to activity of inducible synthase (iNOS) contributes glomerular hyperfiltration in diabetic rats. Two weeks after induction diabetes mellitus by streptozotocin, mean arterial BP (MAP), GFR (inulin clearance), and plasma flow (RPF) (para-aminohippurate clearance) were measured conscious instrumented Diabetic rats had elevated (3129 ± 309 μl/min versus 2297 264 untreated control rats, P < 0.05)...
Proteinuria indicates future renal and cardiovascular morbidity, and, conversely, its reduction is associated with improved outcome. In a randomized, double-blind trial parallel group design, the antiproteinuric effect of candesartan at high doses was analyzed. Patients normal or mildly impaired function, protein excretion rate 1 to 10 g/d, treatment an angiotensin-converting enzyme inhibitor angiotensin receptor blocker for 3 mo were eligible. After 4-wk 16 mg/d candesartan, patients (n =...
To elucidate the mechanisms of hypertensive renal injury, we investigated time course and extent changes in matrix composition, as well cell proliferation infiltration two-kidney, one clip rats. The nonclipped kidneys from sham-operated control rats (n = 5 to 10 each group) were studied at 7, 14, 21, 28 days after clipping. Systolic blood pressure was elevated by day 7 (154 +/- 3 versus 111 4 mm Hg sham group, P < .001, n each). Hypertension resulted an early expansion interstitial volume...
Increasing evidence indicates that inflammation of visceral organs is significantly affected by the autonomic nervous system. Such neuroimmune interactions have not been studied in kidney. Here, we show rat kidney innervated both tyrosine hydroxylase–positive sympathetic efferent nerve fibers and calcitonin gene-related peptide–positive primary afferent fibers, which are found proximity to macrophages dendritic cells. Complete surgical bilateral renal denervation was performed 2 d before...
Adherence to medication has been repeatedly proposed represent a major cause of treatment-resistant hypertension (TRH); however, treatment decisions such as treating TRH with renal denervation depend on accurate judgment adherence. We carefully analyzed adherence rates before and after its effect blood pressure (BP) control.
In this study in conscious rats, we tested the hypothesis that substance P, a central pressor peptide and potential transmitter of pain pathways, could be involved cardiovascular defense reaction is typically associated with unpleasant sensory stimuli. The hemodynamic responses to centrally administered P were pharmacologically characterized. increases blood pressure heart rate after intracerebroventricular injections accompanied by mesenteric renal vasoconstriction hind limb vasodilation...
Renal denervation (RDN) has been shown to be effective in reducing BP treatment-resistant hypertension. Measurement of the renal and sympathetic activity revealed a decrease drive kidney small resistance vessels after RDN. However, consequences on perfusion vascular (RVR), as well central hemodynamics, are unknown.Nineteen patients with hypertension (office BP≥140/90 mmHg, despite at least three antihypertensive drugs [including diuretic], diagnosis confirmed by 24-hour ambulatory...
Rats harboring the mouse Ren-2 transgene develop hypertension despite low levels of plasma renin activity. We tested hypothesis that these rats exhibit an increase in vascular angiotensin formation caused by presence transgene. measured release angiotensins I and II from isolated perfused hindquarters high-performance liquid chromatography radioimmunoassay. Female heterozygous for had significantly elevated mean arterial pressure compared with control (189.3 +/- 9.5 versus 110.0 5.4 mm Hg, p...
Glomerular hyperfiltration may be important for the development of essential hypertension. Both renin-angiotensin system and sympathetic nervous influence renal hemodynamic regulation. To test hypothesis that glomerular can unmasked by activation, hemodynamics humoral components were examined at rest during mental stress in 45 young normotensive healthy subjects 37 people with mild GFR plasma flow (RPF) determined inulin para-aminohippuric acid clearance stress. At rest, RPF, GFR, filtration...
Enhanced vascular ageing is associated with elevated central pulse pressure (cPP), an independent predictor of cardiovascular (CV) events. Although antihypertensive treatment strategies are effective, high residual CV risk remains indicative advanced and largely irreversible damage. Renal denervation (RDN) has been shown to reduce blood (BP) various extents in patients treatment-resistant hypertension (TRH). We hypothesised that cPP predicts BP reduction after RDN.Sixty-three true TRH...
Water-free Na+ storage may buffer extracellular volume and mean arterial pressure (MAP) in spite of retention. We studied the relationship among internal Na+, K+, water balance, MAP Sprague-Dawley rats, with or without deoxycorticosterone-acetate (DOCA) salt, ovariectomy (OVX). The rats were fed a low-salt (0.1% NaCl) high-salt (8% diet for 5 weeks. DOCA salt increased (161+/-14 versus 123+/-4 mm Hg; P<0.05), DOCA-OVX further (181+/-22 P<0.05). total body by &40% to 45%; however, water-free...
We examined the contribution of high blood pressure versus direct mineralocorticoid effects to progression kidney inflammation and fibrosis in established experimental deoxycorticosterone-acetate (DOCA)-salt hypertension.Male Sprague-Dawley rats underwent unilateral nephrectomy received subcutaneous DOCA pellets as well 1% NaCl for drinking. After 4 weeks DOCA-salt hypertension, were either killed (n = 6), or treated with a non-hypotensive dose spironolactone 7) triple therapy...
Other than efferent sympathetic innervation, the kidney has peptidergic afferent fibers expressing TRPV1 receptors and releasing substance P. We tested hypothesis that stimulation of renal nerve activity with agonist capsaicin inhibits tonically by a neurokinin 1 receptor–dependant mechanism. Anesthetized Sprague-Dawley rats were instrumented as follows: (1) arterial venous catheters for recording blood pressure heart rate drug administration; (2) left-sided catheter selective intrarenal...
J Clin Hypertens (Greenwich) . 2012;14:799–801. ©2012 Wiley Periodicals, Inc. Sympathetic overactivity plays a crucial pathogenetic role in the maintenance and aggravation of arterial hypertension patients with end‐stage renal disease (ESRD). Renal denervation has been shown to be effective safe reducing blood pressure (BP) treatment‐resistant hypertension; however, there are only case reports hypertensive ESRD data lacking about possibility small arteries. A woman uncontrolled on chronic...
Inflammation and infection can trigger local tissue Na+ accumulation. This Na+-rich environment boosts proinflammatory activation of monocyte/macrophage-like cells (MΦs) their antimicrobial activity. Enhanced Na+-driven MΦ function requires the osmoprotective transcription factor nuclear activated T 5 (NFAT5), which augments nitric oxide (NO) production contributes to increased autophagy. However, mechanism sensing in MΦs remained unclear. High extracellular levels (high salt [HS]) a...
Renal denervation (DNX) is a treatment for resistant arterial hypertension. Efferent sympathetic nerves regrow, but reinnervation by renal afferent has only recently been shown in the pelvis of rats after unilateral DNX. We examined intrarenal perivascular and efferent surgical Tyrosine hydroxylase (TH), CGRP, smooth muscle actin were identified kidney sections from 12 Sprague-Dawley rats, to distinguish afferents, efferents, vasculature. DNX kidneys nondenervated 1, 4, wk Tissue levels CGRP...