A5108167186- Hippo pathway signaling and YAP/TAZ
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Frailty in Older Adults
- RNA Research and Splicing
- Gene Regulatory Network Analysis
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Congenital heart defects research
- Genomics and Rare Diseases
- Urinary and Genital Oncology Studies
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer-related gene regulation
- Nuclear Structure and Function
- Renal Diseases and Glomerulopathies
- Aldose Reductase and Taurine
- Immune cells in cancer
- Systemic Lupus Erythematosus Research
- PARP inhibition in cancer therapy
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Biomedical Text Mining and Ontologies
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Universitätsklinikum Erlangen
2015-2024
Comprehensive Cancer Center Erlangen
2020-2024
Zentrum für Psychiatrie Emmendingen
2024
Arkana Laboratories
2021-2023
Universidade do Porto
2015
Rede de Química e Tecnologia
2015
University of Pavia
2005-2012
Ludwig-Maximilians-Universität München
2012
Fondazione Salvatore Maugeri
2011
Abstract Myocardial infarction (MI) causes cell death, disrupts electrical activity, triggers arrhythmia, and results in heart failure, whereby 50–60% of MI‐associated deaths manifest as sudden cardiac (SCD). The most effective therapy for SCD prevention is implantable cardioverter defibrillators (ICDs). However, ICDs contribute to adverse remodeling disease progression do not prevent arrhythmia. This work develops an injectable collagen‐PEDOT:PSS (poly(3,4‐ethylenedioxythiophene)...
Article21 July 2020Open Access Source DataTransparent process Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer Nora Feldker Department Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany Search more papers by this author Fulvia Ferrazzi orcid.org/0000-0003-4011-4638 Institute Human Genetics, Nephropathology, Pathology, Harald Schuhwerk Sebastian A Widholz...
Short stature is a common condition of great concern to patients and their families. Mostly genetic in origin, the underlying cause often remains elusive due clinical heterogeneity. We systematically phenotyped 565 where nongenetic causes short were excluded, selected 200 representative for whole-exome sequencing, analyzed identified variants pathogenicity affected genes regarding functional relevance growth. By standard targeted diagnostic phenotype assessment, we known disease only 13.6%...
The role of macrophages in the pathogenesis lupus nephritis, particular their differentiation to a certain subtype (e.g., M1- or M2-like) modulating inflammatory reaction, is unknown. Here we investigated whether M2-like depends on stage nephritis and this correlates with clinical parameters. Using immunohistochemical analysis analyzed renal biopsies from 68 patients (ISN/RPS classes II–V) for infiltration M1-like (iNOS+/CD68+), M2a-like (CD206+/CD68+), M2c-like (CD163+/CD68+), FoxP3+...
Cancer cells alter their metabolism to support malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-B1 (AKR1B1) strongly correlates with epithelial-to-mesenchymal transition (EMT). This association was confirmed in samples from lung cancer patients and an EMT-driven colon mouse model p53 deletion. vitro, mesenchymal-like showed increased AKR1B1 levels, knockdown sufficient revert EMT. An equivalent level of EMT...
Abstract Cardiac tissue engineering is a promising strategy to prevent heart failure. However, several issues remain unsolved, including efficient electrical coupling and incorporating factors enhance maturation vascularization. Herein, biohybrid hydrogel that enhances beating properties of engineered cardiac tissues allows drug release concurrently developed. Gold nanoparticles (AuNPs) with different sizes (18–241 nm) surface charges (33.9–55.4 mV) are synthesized by reducing gold (III)...
Aims Treatment options for advanced urothelial carcinoma (aUC) rapidly evolved: besides immunomodulative therapeutic and inhibitors targeting Fibroblast growth factor receptor (FGFR) alterations, two new antibody‐drug conjugates (ADC), sacituzumab govitecan (SG) enfortumab vedotin (EV), have been approved. However, little is known about the associations of specific aUC properties surface target expression TROP2 NECTIN‐4. Our aim was to characterize TACSTD2 /TROP2 NECTIN‐4 /NECTIN‐4 protein...
Abstract Predictive data mining in clinical medicine deals with learning models to predict patients' health. The can be devoted support clinicians diagnostic, therapeutic, or monitoring tasks. Data methods are usually applied contexts analyze retrospective data, thus giving healthcare professionals the opportunity exploit large amounts of routinely collected during their day‐by‐day activity. Moreover, nowadays take advantage techniques deal huge amount research results obtained by molecular...
Proliferation of mammalian cardiomyocytes stops during the first weeks after birth, preventing heart from regenerating injury. Recently, several studies have indicated that induction cardiomyocyte proliferation can be utilized to regenerate heart. Thus, it is important identify novel factors induce cardiomyocytes. Here, we determine effect TNF-related weak inducer apoptosis (TWEAK) on cardiomyocytes, a cytokine known regulate in other cell types. Stimulation neonatal rat with TWEAK resulted...
Although lysyl oxidase-like 1 (LOXL1) is known as the principal genetic risk factor for pseudoexfoliation (PEX) syndrome, a major cause of glaucoma and cardiovascular complications, no functional variants have been identified to date. Here, we conduct genome-wide association scan on 771 German PEX patients 1,350 controls, followed by independent testing associated in Italian Japanese data sets. We focus 3.5-kb four-component polymorphic locus positioned spanning introns 2 LOXL1 with...
Background. While chimeric antigen receptor (CAR) T cells have achieved encouraging remission rates in hematological malignancies, they demonstrated limited success treating Glioblastoma (GBM), particularly due to high intra- and intertumoral heterogeneity. In this study, we identified a relevant preserved target antigen, Podoplanin (PDPN), evaluated the potential of PDPN- GD2-CAR cell blend overcome GBM Methods. Target screening included clinical samples, healthy tissues lines, as well...
Chromatin modifying enzymes play a critical role in cardiac differentiation. Previously, it has been shown that the targeted deletion of histone methyltransferase, Smyd1, founding member SET and MYND domain containing (Smyd) family, interferes with cardiomyocyte maturation proper formation right heart ventricle. The highly related paralogue, Smyd2 is 3 lysine 4- 36-specific methyltransferase expressed brain. Here, we report differentially during development highest expression neonatal heart....
The extracellular matrix is crucial for organogenesis. It a complex and dynamic component that regulates cell behavior by modulating the activity, bioavailability presentation of growth factors to surface receptors. Here, we determined role protein Nephronectin (Npnt) in heart development using zebrafish model system. vertebrate formed as linear tube which myocardium endocardium are separated layer termed cardiac jelly. During development, jelly swells at atrioventricular (AV) canal,...
Giant cell tumors of soft tissue (GCT-ST) are rare low-grade neoplasms that were at one time thought to represent the counterparts GCT bone (GCT-B) but now known lack H3F3 mutations characteristic osseous GCT. We present six distinctive giant cell-rich expressed keratins and carried a recurrent HMGA2-NCOR2 gene fusion. Patients five females male aged 14-60 years (median, 29). All presented with superficial (subcutaneous) masses removed by conservative marginal (3) or wide (2) local excision....
In the fully digital Caltagirone pathology laboratory, a reverse shift from to manual workflow occurred due server outage in September 2023. Here, insights gained this unplanned transition are explored. Surveying affected pathologists and technicians revealed unanimous preferences for time-saving error-reducing capabilities of methodology. Conversely, return methods highlighted increased dissatisfaction reduced efficiency, emphasising superiority workflows. This case study underscores that...
Small blue round cell sarcomas (SBRCSs) are a heterogeneous group of tumors with overlapping morphologic features but markedly varying prognosis. They characterized by distinct chromosomal alterations, particularly rearrangements leading to gene fusions, whose detection currently represents the most reliable diagnostic marker. Ewing (ESs) common SBRCSs, defined fusions involving EWSR1 and transcription factors ETS family, while frequent non-EWSR1-rearranged SBRCSs harbor CIC rearrangement....
Despite proven clinical efficacy of vedolizumab (VDZ) for inducing and maintaining remission in patients with Crohn's disease (CD) ulcerative colitis (UC), subgroups have no therapeutic benefit from anti-α4β7 integrin therapy VDZ. Within this study, we aimed to identify genetic, cellular, immunological mechanisms that define response failure VDZ treatment. Intestinal RNA sequencing was performed UC CD before at week 14 therapy. α4β7 expression on peripheral mucosal immune cells assessed by...
Genome-wide association studies (GWAS) associated Family with sequence similarity 13, member A (FAM13A) non-small cell lung cancer (NSCLC) occurrence. Here, we found increased numbers of FAM13A protein expressing cells in the tumoral region tissues from a cohort patients NSCLC. Moreover, inversely correlated CTLA4 but directly HIF1α levels control these patients. Consistently, RhoGAP was to be T effector molecules like and Tbet downregulated immunosuppressive CD4+CD25+Foxp3+CTLA4+ cells....
Histological scoring plays a key role in the assessment of disease activity ulcerative colitis [UC] and is also important Crohn´s [CD]. Currently, there no common available for UC CD. We aimed to validate Inflammatory Bowel Disease [IBD]-Distribution [D], Chronicity [C], Activity [A] score [IBD-DCA score] histological IBD.Inter- intra-rater reliability were assessed by 16 observers on biopsy specimens from 59 patients with 25 Construct validity responsiveness treatment retrospectively...
Abstract Summary: TimeClust is a user-friendly software package to cluster genes according their temporal expression profiles. It can be conveniently used analyze data obtained from DNA microarray time-course experiments. implements two original algorithms specifically designed for clustering short time series together with hierarchical and self-organizing maps. Availability: executable files Windows LINUX platforms downloaded free of charge non-profit institutions the following web site:...
After birth cardiomyocytes undergo terminal differentiation, characterized by binucleation and centrosome disassembly, rendering the heart unable to regenerate. Yet, it has been suggested that newborn mammals regenerate their hearts after apical resection cardiomyocyte proliferation. Thus, we tested hypothesis either inhibits, delays, or reverses disassembly binucleation. Our data show rather transiently accelerates as well rate of Consistent with nearly 2-fold increased there was a increase...
In cancer, the activating transcription factor 2 (ATF2) has pleiotropic functions in cellular responses to growth stimuli, damage, or inflammation. Due only limited studies, significance of ATF2 colorectal cancer (CRC) is not well understood. We report that low levels correlated with worse prognosis and tumor aggressiveness CRC patients. NanoString gene expression ChIP analysis confirmed trophoblast cell surface antigen (TROP2) as a novel inhibitory target gene. This inverse correlation was...