A5044761873- Medical Imaging Techniques and Applications
- Inflammatory Myopathies and Dermatomyositis
- Lymphatic System and Diseases
- Radiomics and Machine Learning in Medical Imaging
- Diagnosis and Treatment of Venous Diseases
- Inflammatory Bowel Disease
- Radiopharmaceutical Chemistry and Applications
- Intestinal Malrotation and Obstruction Disorders
- Congenital heart defects research
- Connective tissue disorders research
- Glioma Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Esophageal and GI Pathology
- Hematological disorders and diagnostics
- Sympathectomy and Hyperhidrosis Treatments
- Microscopic Colitis
- Heterotopic Ossification and Related Conditions
- Cardiac Imaging and Diagnostics
- Lymphatic Disorders and Treatments
- Advanced MRI Techniques and Applications
- Body Contouring and Surgery
- Congenital Heart Disease Studies
- RNA modifications and cancer
- Congenital gastrointestinal and neural anomalies
- Genetic Neurodegenerative Diseases
Odense University Hospital
2015-2024
University of Southern Denmark
2023
Klinik und Poliklinik für Nuklearmedizin
2011-2020
Objective Cardiac events are a major cause of death in patients with idiopathic inflammatory myopathies. The study objective was controlled setting to describe cardiac abnormalities by noninvasive methods cohort polymyositis (PM) or dermatomyositis (DM) and identify predictors for dysfunction. Methods In cross‐sectional study, 76 PM/DM 48 matched healthy controls (HCs) were assessed serum levels troponin I, electrocardiography, Holter monitoring, echocardiography tissue Doppler imaging,...
Abstract Background Heart failure due to myocardial infarction (MI) involves fibrosis driven by epicardium‐derived cells (EPDCs) and cardiac fibroblasts, but strategies inhibit provide cardio‐protection remains poor. The imprinted gene, non‐canonical NOTCH ligand 1 (Dlk1), has previously been shown mediate in the skin, lung liver, very little is known on its effect heart. Methods Herein, human pericardial fluid/plasma tissue biopsies were assessed for DLK1, whereas spatiotemporal expression...
Microfibrillar-associated protein 4 (MFAP4) is localized to elastic fibers in blood vessels and the interalveolar septa of lungs further present bronchoalveolar lavage. Mfap4 has been previously suggested be involved elastogenesis lung. We tested this prediction aimed characterize pulmonary function changes emphysematous that occur Mfap4-deficient ( −/− ) mice. Significant included increases total lung capacity compliance, which were evident mice at 6 8 mo but not 3 age. Using vivo...
Abstract Microglia are activated following cerebral ischemia and increase their production of the neuro- immunomodulatory cytokine tumor necrosis factor (TNF). To address function TNF from this cellular source in focal we used conditional knock out mice (LysMcreTNF fl/fl ) which gene was deleted cells myeloid lineage, including microglia. The deletion reduced secreted levels lipopolysaccharide-stimulated cultured primary microglia by ~93%. Furthermore, phosphorylated-ERK/ERK ratios were...
After birth cardiomyocytes undergo terminal differentiation, characterized by binucleation and centrosome disassembly, rendering the heart unable to regenerate. Yet, it has been suggested that newborn mammals regenerate their hearts after apical resection cardiomyocyte proliferation. Thus, we tested hypothesis either inhibits, delays, or reverses disassembly binucleation. Our data show rather transiently accelerates as well rate of Consistent with nearly 2-fold increased there was a increase...
Lymphedema is a common and debilitating complication following cancer treatment with surgical lymph node excision radiotherapy. Currently there are no curative treatments for lymphedema. Animal models that intended to replicate the disease have been inadequate, making troublesome transition from experimental therapeutic studies into clinic. It therefore imperative establish an animal model can reliably clinical lymphedema.To discover optimal method of lymphedema induction, ablation...
Objective: Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized by progressive weakening and dilatation of the wall. Microfibrillar-associated protein 4 (MFAP4) an extracellular matrix (ECM) involved in induction remodeling. This study aimed to investigate if MFAP4 facilitates development AAA characterize underlying MFAP4-mediated mechanisms. Approach Results: Double apolipoprotein E- Mfap4-deficient (ApoE-/-Mfap4-/-) control E-deficient (ApoE-/-) mice were...
Background: Lymphedema is one of the most common complications following breast cancer. Axillary lymph node dissection and radiotherapy are two well-known risk factors resulting in either removal or damage to nodes. As stem cells known for their regenerative capabilities, they could theoretically repair/restore damaged vessels leading a decrease lymphedema.Methods: We evaluated treatment SVF ASC on mouse lymphedema model. Forty-five mice were allocated into three groups containing 15 each....
Abstract We investigated the feasibility of using a dopamine transporter (DaT) tracer ligand ([ 123 I]FP-CIT) along with novel multi-pinhole brain collimators for dynamic single photon emission computed tomography (SPECT) in suspected Parkinson's disease patients. Thirteen patients underwent acquisitions before standard imaging. Uptake values were corrected partial volume effects. Specific binding ratio (SBR calc ) was calculated, reflecting potential relative to non-displaceable (BP ND...
Brain tumor volume assessment is a major challenge. Molecular imaging using PET may be promising option because it reflects the biologically active cells. We compared agreement between PET- and histology-derived volumes in an orthotopic glioblastoma rat model with noninfiltrating (U87MG) infiltrating (T87) phenotype 2 different radiotracers, image reconstruction algorithms, parametric imaging, segmentation techniques. <b>Methods:</b> Rats U87MG- T87-derived glioblastomas were continuously...
Lymphoscintigraphy is commonly used to assess breast cancer-related lymphedema. However, a reliable quantitative method that clearly distinguishes normal lymphatic function from lymphedema desired. We propose based upon the physiological mean transit time (MTT) measure of lymph fluid passing through arm.Eleven patients, aged 34-68 years, with unilateral arm following cancer treatment underwent simultaneous bilateral lymphoscintigraphy using intradermal injection 99mTc-labeled human serum...
Objective methods for examination of pouch function are warranted a better understanding the functional result and treatment dysfunction. The objective this study was to evaluate results scintigraphic intestinal transit time defaecography compared function, mucosal condition questionnaire on quality life (QoL). This cross-sectional included 21 patients. Scintigraphic determined with use Tc-99m. Pouch assessed by number bowel movements, volume, continence. evaluated endoscopy histology....
Lymphoscintigraphy has often been used for evaluating arm lymphatic dysfunction, but no optimal approach quantification so far emerged. We propose a quantifiable measure of function that we applied in patients treated breast cancer.Eleven patients, aged 34-68 years, with unilateral lymphedema following cancer treatment underwent bilateral lymphoscintigraphy using intradermal injection both hands technetium-99m-labeled human serum albumin and sequential 5 min imaging hours. The mean transit...
Nuclear imaging is increasingly being used in the diagnostic work-up of idiopathic inflammatory myopathy (IIM). Increased muscular uptake technetium-99m-pyrophosphate (99mTc-PYP) has hitherto been assessed qualitatively by planar scintigraphy. We set out to perform quantitative tomographic scintigraphy IIM. Ninety IIM patients and 48 control subjects underwent 99mTc-PYP single-photon emission computed tomography (SPECT)/CT upper lower body. Scans were evaluated visually an intensity score...
Lymphedema is a common complication following breast cancer treatment with axillary lymphadenectomy and radiotherapy. Currently, there no curative for this disease, hence need new therapeutic suggestions. The aim of study was to investigate the effect hyaluronidase (HYAL) injections after inducing hindlimb lymphedema in 36 female C57BL/6 mice. HYAL were administered every second day 14 days three groups: (1) 1 week followed by saline week, (2) 2 weeks, (3) weeks. Volume limb weekly assessed...
<h3>Background</h3> Knowledge of cardiac involvement in idiopathic inflammatory myopathies (IIM) is limited and a matter debate with reported frequencies between 6% 75%. Although clinically overt disease rare, events are the major cause death IIM. No studies heart by SPECT/CT newly diagnosed, untreated adults IIM have been performed. <h3>Objectives</h3> To examine patients imaging compared to gender- age- matched control group. <h3>Methods</h3> In cross-sectional, single-centre study 14...
<h3>Background</h3> Diagnosis of idiopathic inflammatory myopathies (IIMs) is challenging and so far no pathognomonic signs exist by imaging. Few radionuclide imaging techniques have been tested for this purpose, mainly <sup>99m</sup>Tc-pyrophosphate planar <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18F-</sup>FDG-PET/CT). However, <sup>99m</sup>Tc-PYP uptake has assessed visually at best graded semi-quantitatively. <h3>Objectives</h3> We aimed...