A5046893521- Cancer, Hypoxia, and Metabolism
- Aldose Reductase and Taurine
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Heat shock proteins research
- Cancer Cells and Metastasis
- Biochemical and Molecular Research
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Diet, Metabolism, and Disease
- Advanced biosensing and bioanalysis techniques
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- FOXO transcription factor regulation
- Carbohydrate Chemistry and Synthesis
- Selenium in Biological Systems
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Lipids, and Metabolism
- History of Medicine Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
University of Southern Denmark
2020-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2017-2021
Universitätsklinikum Erlangen
2017-2020
King's College London
2017
Cancer cells alter their metabolism to support malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-B1 (AKR1B1) strongly correlates with epithelial-to-mesenchymal transition (EMT). This association was confirmed in samples from lung cancer patients and an EMT-driven colon mouse model p53 deletion. vitro, mesenchymal-like showed increased AKR1B1 levels, knockdown sufficient revert EMT. An equivalent level of EMT...
Cancer cells frequently boost nucleotide metabolism (NM) to support their increased proliferation, but the consequences of elevated NM on tumor de-differentiation are mostly unexplored. Here, we identified a role for thymidylate synthase (TS), enzyme and established drug target, in cancer cell investigated its clinical significance breast (BC). In vitro, TS knockdown population CD24+ differentiated cells, attenuated migration sphere-formation. RNA-seq profiling indicated repression...
The identification of novel targets is paramount importance to develop more effective drugs and improve the treatment non-small cell lung cancer (NSCLC), leading cause cancer-related deaths worldwide. Since cells alter their metabolic rewiring during tumorigenesis along progression, targeting key players metabolism-associated proteins represents a valuable approach with high therapeutic potential. Metabolic fitness relies on functionality heat shock (HSPs), molecular chaperones that...
Abstract With the advent of healthcare globalization, interprofessional collaboration has become increasingly important on an international scale. This longitudinal study evaluated group dynamics in International Collaboration and Exchange Program , a global online program students across 33 universities from diverse backgrounds, including medicine, dentistry, pharmacy, biomedical science. In groups 4 to 6, participants engaged regular discussions projects relating anatomy education health....
Abstract Thymidylate synthase ( TS ) is a fundamental enzyme of nucleotide metabolism and one the oldest anti‐cancer targets. Beginning from analysis gene array data NCI ‐60 panel cancer cell lines, we identified significant correlation at both protein level between markers epithelial‐to‐mesenchymal transition EMT ), developmental process that allows cells to acquire features aggressiveness, like motility chemoresistance. levels were found be significantly augmented in mesenchymal‐like...
Abstract Background Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT’s different functional aspects in non-small cell lung cancer (NSCLC). Thymidylate synthase (TS) has been previously correlated with EMT transcription factor ZEB1 NSCLC imparts resistance against anti-folate chemotherapy. In this study, we establish a correlation between TS, EMT, chemotherapy metastasis...
Abstract Since their discovery, microRNAs (miRNAs) have been widely studied in almost every aspect of biology and medicine, leading to the identification important gene regulation circuits cellular mechanisms. However, investigations are generally focused on analysis downstream targets biological functions overexpression knockdown approaches, while miRNAs endogenous levels activity remain poorly understood. Here, we used plasticity-regulating process epithelial-to-mesenchymal transition...
Abstract Despite recent treatment advances, non-small cell lung cancer (NSCLC) remains one of the leading causes cancer-related deaths worldwide, and therefore it necessitates exploration new therapy options. One commonly shared feature malignant cells is their ability to hijack metabolic pathways confer survival or proliferation. In this study, we highlight importance polyol pathway (PP) in NSCLC metabolism. This solely responsible for metabolizing glucose fructose based on enzymatic...
Attempts have been made to treat nonsense-associated genetic disorders by chemical agents and hence an improved mechanistic insight into the decoding of readthrough signals is essential for identification characterisation factors treatment these disorders. To identify either novel compounds or genes that modulate translation readthrough, we employed dual reporter-based high-throughput screens use enzymatic fluorescence activities screened bioactive National Institute Neurological Disease...
Abstract The epithelial‐to‐mesenchymal transition (EMT) plays a central role in the development of cancer metastasis and resistance to chemotherapy. However, its pharmacological treatment remains challenging. Here, we used an EMT‐focused integrative functional genomic approach identified inverse association between short‐chain fatty acids (propionate butanoate) EMT non‐small cell lung (NSCLC) patients. Remarkably, with propionate vitro reinforced epithelial transcriptional program promoting...
The physico-chemical characteristics of the extracellular matrix (ECM) cause mechanical cues that could elicit responses in survival rate cortical neuronal cells. Efficient neurite outgrowth vitro, is critical for successful cultivation cells and potential attempts at regeneration central nervous system (CNS) vivo. Relatively soft hydrophilic, microbially synthesized aromatic polyester, polyhydroxyphenylvalerate (PHPV) was blended 50:50 with stiff hydrophobic polycaprolactone (PCL)...
BACKGROUND/AIMS: Compelling evidence indicates that CK2α, which is one of the two catalytic isoforms protein kinase CK2, required for cell viability and plays an important role in proliferation differentiation. While much known on CK2 context disease states, particularly cancer, its critical non-cancerous growth has not been extensively investigated. METHODS: In present study, we have employed a line derived from rat heart with inducible down-regulation CK2α CK2α-knockout mouse tissue to...
Trans-(±)-kusunokinin (KU), a potential anticancer agent, has been reported as an AKR1B1 inhibitor, leading to the inhibition of oxidative stress and alteration EMT-related proteins in aggressive breast cancer. Overexpression is associated with poor prognosis non-small cell lung cancer (NSCLC). Therefore, we aimed elucidate mechanism action by which KU mediates its effects through NSCLC. The results indicate that inhibits proliferation dose-dependent manner both human A549 cells lines...
Clear cell renal carcinoma (ccRCC) is a type of cancer characterized by vast intracellular accumulation lipids that are critical to sustain growth and viability the cells in tumour microenvironment. Stearoyl-CoA 9-desaturase 1 (SCD-1) an essential enzyme for synthesis monounsaturated fatty acids consistently overexpressed all stages ccRCC growth. Human clear lines were treated with small-molecule inhibitors protein kinase CK2. Effects on expression levels SCD-1 investigated RNA-sequencing,...
Summary Sustained cell proliferation is a fundamental hallmark of cancer, yet its mechanism remains elusive, particularly in context heterogenous tumor organization, intercellular interactions, and metabolite exchanges. In this study, we uncover growth via collective , where cells connected by gap junctions enable equilibration thymidylate (dTMP) to allow the lacking canonical de novo dTMP biosynthesis salvage driven synthase ( TYMS ) thymidine kinase 1 TK1 enzymes, respectively. Collective...
Abstract Deregulated nucleotide metabolism, and in particular increased pyrimidine metabolism (PyMet), has been shown to contribute various pathological features of cancer including chemoresistance epithelial-to-mesenchymal transition. However, often encompasses complex signaling metabolic pathway cascades for its progression, understanding these molecular regulatory processes is quite limited. Therefore, a comprehensive pan-cancer analysis around 10,000 gene expression profiles 32 types was...
Abstract Epithelial to mesenchymal transition (EMT) is a developmental cellular program driving metastasis and chemo-resistance in cancer, but its pharmacological treatment has been so far challenging. Targeting deregulated metabolic processes cancer emerging as realistic therapeutic strategy. Here, we used an EMT-focussed integrative functional genomic approach identified negative association of the short-chain fatty acids propionate butanoate with EMT non-small cell lung (NSCLC) patients....
Abstract Background Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness and chemoresistance of carcinomas is an important determinant metastasis. Little known about how various pathways coordinate to elicit EMT’s different functional aspects. Even lesser has been studied in this context non-small cell lung cancer (NSCLC), where EMT a key event during early tumorigenesis. Thymidylate synthase (TS), proliferation enzyme, previously correlated with transcription factor ZEB1...
Unani Medicine (Greco-Arab Medicine) is one of the ancient system medicine. A vast array literature about liver diseases has been documented in Medicine. Liver an organ for origin Quwaa (Natural power). 1 Galen, (129-217 AD) even stated counterpart with sun, a source energy others planets. 2 also production humours (akhlat) nourishment, growth and development body. 1, Each four named dam (sanguine), balgam (phlegm), safra (yellow bile) sauda (black bile), carries their own normal...
<p>SUPPLEMENTARY FIGURE 1 Correlation of VIM/CDH1 ratios in different datasets. The list 35 genes significantly correlated with EMT. Lack correlation between AKR1B10 mRNA levels and SUPPLEMENTARY 2 AKR1B1 are modulated by ZEB1, but not a direct fashion. 3 Characteristics the NSCLC patients stained immunohistochemistry impact on survival. Alterations influence cancer cells growth stemness. 4 Impact SORD knockdown invasion. combination inhibition polyol pathway gene cisplatin suppresses...
<div>Abstract<p>Cancer cells alter their metabolism to support malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-B1 (<i>AKR1B1</i>) strongly correlates with epithelial-to-mesenchymal transition (EMT). This association was confirmed in samples from lung cancer patients and an EMT-driven colon mouse model p53 deletion. <i>In vitro</i>, mesenchymal-like showed increased AKR1B1...
<p>SUPPLEMENTARY FIGURE 1 Correlation of VIM/CDH1 ratios in different datasets. The list 35 genes significantly correlated with EMT. Lack correlation between AKR1B10 mRNA levels and SUPPLEMENTARY 2 AKR1B1 are modulated by ZEB1, but not a direct fashion. 3 Characteristics the NSCLC patients stained immunohistochemistry impact on survival. Alterations influence cancer cells growth stemness. 4 Impact SORD knockdown invasion. combination inhibition polyol pathway gene cisplatin suppresses...