A5025708100- Heat shock proteins research
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Advanced biosensing and bioanalysis techniques
- Cellular Mechanics and Interactions
- ATP Synthase and ATPases Research
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Aldose Reductase and Taurine
- RNA Interference and Gene Delivery
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- RNA modifications and cancer
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2024
Fondazione IRCCS Istituto Nazionale dei Tumori
2023
The identification of novel targets is paramount importance to develop more effective drugs and improve the treatment non-small cell lung cancer (NSCLC), leading cause cancer-related deaths worldwide. Since cells alter their metabolic rewiring during tumorigenesis along progression, targeting key players metabolism-associated proteins represents a valuable approach with high therapeutic potential. Metabolic fitness relies on functionality heat shock (HSPs), molecular chaperones that...
Abstract Background Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT’s different functional aspects in non-small cell lung cancer (NSCLC). Thymidylate synthase (TS) has been previously correlated with EMT transcription factor ZEB1 NSCLC imparts resistance against anti-folate chemotherapy. In this study, we establish a correlation between TS, EMT, chemotherapy metastasis...
Osteosarcoma (OS) is the most common primary bone tumor in children and adolescent. Surgery multidrug chemotherapy are standard of treatment achieving 60-70% event-free survival for localized disease at diagnosis. However, metastatic disease, prognosis dismal. Exploiting immune system activation setting such unfavorable mesenchymal tumors represents a new therapeutic challenge.In competent OS mouse models bearing two contralateral lesions, we tested efficacy intralesional administration TLR9...
Abstract Since their discovery, microRNAs (miRNAs) have been widely studied in almost every aspect of biology and medicine, leading to the identification important gene regulation circuits cellular mechanisms. However, investigations are generally focused on analysis downstream targets biological functions overexpression knockdown approaches, while miRNAs endogenous levels activity remain poorly understood. Here, we used plasticity-regulating process epithelial-to-mesenchymal transition...
Abstract Despite recent treatment advances, non-small cell lung cancer (NSCLC) remains one of the leading causes cancer-related deaths worldwide, and therefore it necessitates exploration new therapy options. One commonly shared feature malignant cells is their ability to hijack metabolic pathways confer survival or proliferation. In this study, we highlight importance polyol pathway (PP) in NSCLC metabolism. This solely responsible for metabolizing glucose fructose based on enzymatic...
Abstract As 2D surfaces fail to resemble the tumoral milieu, current discussions are focused on which 3D cell culture strategy may better lead cells express in vitro most of malignant hints described vivo. In this study, question is assessed by analyzing full genetic profile MCF7 cultured either as spheroids‐considered “gold standard” for cancer research‐ or immobilized tumor‐like microcapsules, RNA‐Seq and transcriptomic methods, allowing discriminate at big‐data scale, can features...
Abstract Background Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness and chemoresistance of carcinomas is an important determinant metastasis. Little known about how various pathways coordinate to elicit EMT’s different functional aspects. Even lesser has been studied in this context non-small cell lung cancer (NSCLC), where EMT a key event during early tumorigenesis. Thymidylate synthase (TS), proliferation enzyme, previously correlated with transcription factor ZEB1...
ABSTRACT Since their discovery, microRNAs (miRNA)s have been widely studied in almost every aspect of biology and medicine, leading to the identification important gene regulation circuits cellular mechanisms. However, investigations are generally focused on analysis downstream targets biological functions overexpression knockdown approaches, while miRNAs endogenous levels activity remain poorly understood. Here, we used plasticity-regulating process epithelial-to-mesenchymal transition...
ABSTRACT The identification of novel targets is paramount importance to develop more effective drugs and improve the treatment non-small cell lung cancer (NSCLC), leading cause cancer-related deaths worldwide. Since cells alter their metabolic rewiring during tumorigenesis along progression, targeting key players metabolism-associated proteins represents a valuable approach with high therapeutic potential. Metabolic fitness relies on functionality heat shock (HSPs), molecular chaperones that...