A5001403684- Pulmonary Hypertension Research and Treatments
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Polysaccharides Composition and Applications
- Advancements in Transdermal Drug Delivery
- Polysaccharides and Plant Cell Walls
- Malaria Research and Control
- RNA Interference and Gene Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Mosquito-borne diseases and control
- Tuberculosis Research and Epidemiology
- Seaweed-derived Bioactive Compounds
- Nigella sativa pharmacological applications
- Cardiac Fibrosis and Remodeling
- Lipid Membrane Structure and Behavior
- Phytochemicals and Medicinal Plants
- Pneumonia and Respiratory Infections
- Oral Health Pathology and Treatment
- Crystallization and Solubility Studies
- Chemical Synthesis and Analysis
- Phytochemistry and biological activity of medicinal plants
- Metalloenzymes and iron-sulfur proteins
- Machine Learning in Bioinformatics
- Food composition and properties
University of Dhaka
1970-2024
University of Glasgow
2023
University of Bradford
2017-2021
Dengue, a mosquito transmitted febrile viral disease, is serious public health concern in Bangladesh. Despite significant number of incidences and reported deaths each year, there are inadequate studies relating the temporal trends clinical parameters as well socio-demographic factors with course disease. Therefore, this study aims to associate parameters, demographic behavioral dengue patients admitted tertiary care hospital Dhaka, Bangladesh during 2019 outbreak Data were collected from...
Attempts have been made to treat nonsense-associated genetic disorders by chemical agents and hence an improved mechanistic insight into the decoding of readthrough signals is essential for identification characterisation factors treatment these disorders. To identify either novel compounds or genes that modulate translation readthrough, we employed dual reporter-based high-throughput screens use enzymatic fluorescence activities screened bioactive National Institute Neurological Disease...
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder characterized by the remodelling of pre-capillary pulmonary arteries. The vascular observed in PAH patients results from excessive proliferation and apoptosis resistance smooth muscle cells (PASMCs) endothelial (PAECs). We have previously demonstrated that mutations type II receptor for bone morphogenetic protein (BMPRII) underlie majority familial inherited forms disease. further BMPRII deficiency promotes...
A simple, reliable, precise and sensitive UV-spectrophotometric method was developed validated for the estimation of azithromycin in pharmaceutical dosage form compared with official USP 2010 method. The proposed utilizes oxidation potassium permanganate to liberate formaldehyde. This formaldehyde reacts acetone-ammonium reagent produces yellow colored chromogen 3,5-diacetyl-2,6-dihydrolutidine. solution exhibited a maximum absorption at 412 nm which can be detected UVspectrophotometer....
Salvia hispanica L. (Chia) seed improves liver marker enzymes, lipid profile and antioxidant enzyme activity. The aim of the research work was to evaluate hepatic enzymes activity chia supplementation in high fat diet fed mice. Liver profile, oxidative stress, activity, histology were evaluated for Here, ALT, AST, ALP done test. Cholesterol, triglyceride, HDL, LDL measured profiles. MDA, NO, AOPP, MPO stress Catalase SOD performed measuring Hematoxylin eosin Prussian blue staining purposes....
The present study was intended to develop a new oral mucosal dosage form with view of solving problems the topical administration Lidocaine, local anesthetic drug, in cavity. drug formulated as sustained release mucoadhesive bilayered tablets using polymers. first layer, consisting impermeable backing, prepared by compression Kollidon SR, Mg-stearate, Aerosil and talc blend hydrolic press at 5 ton pressure for seconds. second responsible buccal delivery tablet retention on mucosa obtained...
Diclofenac sodium (DS) microspheres were prepared with two different polymers, ethyl cellulose (EC) and acetate phthalate (CAP). Emulsification-solvent evaporation method was used to prepare the microspheres. Liquid paraffin containing 1.5% (w/w) span 80 external phase acetone-polymer solution internal phase. EC CAP, both as single mixture, encapsulate DS. more spherical in shape showed entrapment efficiency than CAP The size of varied between 560-920 μm high 90% loading obtained. In vitro...
Four cycloartane type triterpenoids and three stigmastane steroids were isolated from the methanolic extract of stem root part Pothos scandens L. (Araceae), a Bangladeshi medicinal plant by high performance liquid chromatographic technique. The compounds characterized as 24-methylenecycloartanol (1), 24-methylenecycloartenone (2), 24-en-cycloartenone (3), 24-methylenecycloartanyl ferulate (4), stigmast-4-en-3-one (5), stigmast-4,22-diene-3-one (6) β-sitosterol glucoside (7) through extensive...
Background: Improvement of the dissolution rate and solubility poorly aqueous soluble drugs using solid dispersion (SD) techniques are considered as one most attractive processes. The focus current research project is to investigate property lovastatin (LVT) SD technology comprising drug, excipients, carrier. Aim Objectives: main objective this study augment profile LVT, a statin medication belongs biopharmaceutics classification system Class II water-insoluble, by applying...
Background and aim: Bovine, zoonotic, wildlife tuberculosis are caused by Mycobacterium Bovis, whose attenuated form is used in cancer treatment. There several proteins present its genome considered as uncharacterized or hypothetical proteins. We aim to predict the structure function of an protein bacterial this pathogenic bacteria, using bioinformatics tools. Materials methods: Using silico techniques, secondary tertiary structures selected were predicted further validated. Bioinformatics...
The ocean consists of versatile domain lives which can be exploited for human health benefits because diversified secondary metabolites. Seaweeds, generally called macroalgae, are commonly found in the coastal region Bay Bengal. But none them were investigated properly their biological activities. Hence, this study was performed to investigate antioxidant, antimicrobial, cytotoxic and membrane stabilizing activities along with total phenolic content crude methanolic extract three seaweeds...
Oral administration is the most common drug delivery route with high levels of patient acceptance. However, oral therapeutic proteins/peptides extremely difficult, and improving pharmacological bioavailability still a challenging goal because poor membrane permeability, molecular weight, enzymatic degradation these drugs. Lipid-based nanocarriers represent viable means for enhancing protein or peptide drugs while minimizing toxicity. Nowadays, like other macromolecules are promising...
Many diseases that affect the liver can be treated by natural products derived from plants.The purpose of this investigation was to evaluate efficacy Senna alexandrina leaf powder supplementation on oxidative stress, inflammation, fibrosis, and hepatic damage in Swiss albino mice induced carbon tetrachloride (CCl4).Plasma levels ALP, ALT AST were increased after CCl4 administration compared controls, but significantly decreased these activities.In addition, CCl4-treated showed elevated...
Heterozygous germline mutations in the gene encoding type II bone morphogenetic protein receptor (BMPRII) underlie majority (~80%) of familial form pulmonary arterial hypertension (HPAH).<sup>1</sup> PAH is a devastating cardiovascular disorder caused by narrowing blood vessels lungs. We earlier demonstrated that <i>BMPR2</i> impinge upon BMP signalling pathway and potentiate TGF-β² leading to abnormal proliferation apoptosis resistance endothelial smooth muscle cells (PASMCs).<sup>2,3</sup>...