A5081630454- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic and Hepatic Oncology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Enhanced Recovery After Surgery
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nutrition and Health in Aging
- Colorectal Cancer Screening and Detection
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Surgical Treatments
- Pancreatitis Pathology and Treatment
- Hip and Femur Fractures
- Cholinesterase and Neurodegenerative Diseases
- Anesthesia and Neurotoxicity Research
- Alzheimer's disease research and treatments
- Radiomics and Machine Learning in Medical Imaging
- Heavy Metal Exposure and Toxicity
- Stress Responses and Cortisol
- Nuclear Receptors and Signaling
- Noise Effects and Management
- Chemokine receptors and signaling
- Tryptophan and brain disorders
University College Dublin
2011-2025
Johnson & Wales University
2023
Providence College
2023
Inner Mongolia Agricultural University
2023
University of North Carolina at Charlotte
2016-2022
Michigan United
2022
University of Michigan
2022
Carolinas Medical Center
2016-2021
Atrium Medical Cente
2020
Carolinas Healthcare System
2016-2018
Abstract: Polysialylated neurons, located at the inner border of dentate granule cell layer, have been demonstrated to exhibit time‐dependent change in their frequency 10–12 h following training Morris water maze, a spatial learning paradigm. Such was not observed animals required locate visible platform or those rendered amnesic with scopolamine. This response capable rapid reactivation further stimuli manner that independent circadian influence. These learning‐associated modulations neural...
Abstract: Animals trained in a passive avoidance task exhibit transient time‐dependent increase hippocampal neural cell adhesion molecule (NCAM) polysialylation at 12–24 h following the initial learning trial. Using immunocytochemical techniques with monoclonal antibody that specifically recognises NCAM‐polysialic acid homopolymers, distinct population of granule‐like cells, border granule layer and hilus dentate gyrus adult rat hippocampus, has been demonstrated to change frequency 10–12...
Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia microglia. In particular, can affect cardinal cellular molecular processes hippocampal-dependent long-term memory consolidation including synaptic plasticity, scaling neurogenesis. The chemokine, CX3CL1 (fractalkine), has been shown modulate transmission potentiation (LTP) CA1 pyramidal cell layer hippocampus. Here, we confirm...
Abstract Cellular exposure to hypoxia results in altered gene expression a range of physiologic and pathophysiologic states. Discrete cohorts genes can be either up- or down-regulated response hypoxia. While the Hypoxia-Inducible Factor (HIF) is primary driver hypoxia-induced adaptive expression, less known about signalling mechanisms regulating hypoxia-dependent repression. Using RNA-seq, we demonstrate that equivalent numbers are induced repressed human embryonic kidney (HEK293) cells. We...
Image-based deep learning models (DLMs) have been used in other disciplines, but this method has yet to be predict surgical outcomes.To apply image-based complexity, defined as need for component separation, and pulmonary wound complications after abdominal wall reconstruction (AWR).This quality improvement study was performed at an 874-bed hospital tertiary hernia referral center from September 2019 January 2020. A prospective database queried patients with ventral hernias who underwent...
Prenatal exposure to cocaine causes abnormalities in foetal brain development, which are linked later development of anxiety, depression and cognitive dysfunction. Previous studies rodent models have indicated that prenatal affects proliferation, differentiation connectivity neural cell types. Here, using cerebral organoids derived from the human iPSC line HPSI1213i-babk_2, we investigated cocaine-induced changes gene expression regulatory landscape at an early developmental time point,...
Objective Hernia recurrence and surgical site infection (SSI) are grave complications in Abdominal Wall Reconstruction (AWR). This study aimed to develop multicenter deep learning models (DLMs) developed for predicting complexity, using Component Separation Technique (CST) as a surrogate, the risk of infections AWR, preoperative computed tomography (CT) images. Methods Multicenter were created deidentified CT images from two tertiary AWR centers. The with ResNet-18 architecture. Model...
Abstract: Transient and time‐dependent modulations of neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus rodent hippocampus are a feature spatial nonspatial forms learning. In hippocampal formation, polysialic acid immunoreactivity was localized to granule‐like cells their mossy fibre axons. We now demonstrate latter extend CA3 region where apparent recurrent Schaffer collaterals were labelled. The axons CA1 pyramidal layer immunopositive, as subiculum that they...
Modulation of neural cell adhesion molecule polysialylation (NCAM PSA) state has been proposed to underlie morphofunctional change associated with consolidation memory in the rodent, and its age-dependent decline be related impaired cognitive function. To establish whether this may a human correlate decline, we determined expression PSA hippocampal dentate gyrus using postmortem tissue derived from individuals who exhibited no obvious neuropathology. As immunoreactivity 5-month infant was...
A learning event initiates a cascade of altered gene expression leading to synaptic remodelling within the hippocampal dentate gyrus, structure vital memory formation. To illuminate this transcriptional program plasticity we used microarrays quantify mRNA from rat gyrus at increasing times following passive avoidance learning. Approximately, 500 known genes were transcriptionally regulated across 24 h post-training period. The 0-2 period saw up-regulation involved in transcription while with...
Long-term memory is formed by alterations in glutamate-dependent excitatory synaptic transmission, which turn regulated synaptosomal protein of 25 kDa (SNAP-25), a key component the soluble N-ethylmaleimide-sensitive factor attachment receptor complex essential for exocytosis neurotransmitter-filled vesicles. Both reduced and excessive SNAP-25 activity has been implicated various disease states that involve cognitive dysfunctions such as attention deficit hyperactivity disorder,...
Neoadjuvant therapy may improve survival of patients with pancreatic adenocarcinoma; however, determining response to is difficult. Artificial intelligence allows for novel analysis images. We hypothesized that a deep learning model can predict tumor NAC.Patients cancer receiving neoadjuvant prior pancreatoduodenectomy were identified between November 2009 and January 2018. The College American Pathologists Tumor Regression Grades 0-2 defined as pathologic (PR) grade 3 no (NR). Axial images...
Expressed throughout the central nervous system, myocardin-related, megakaryoblastic acute leukemia 1 and 2 (Mkl1/2) are transcriptional cofactors that can be found tethered in cytoplasm to monomeric actin but on synaptic activation translocate nucleus associate with transcription factors such as serum response factor (SRF) regulate expression of structural genes. This implies a potential role for Mkls linking activity, through gene-expression control, neuronal plasticity. Here, we present...
Abstract Information storage in the brain depends on ability of neurons to alter synaptic connectivity within key circuitries such as hippocampus. Memory‐associated plasticity is mediated by a temporal cascade de novo protein synthesis and altered processing. Here, we have used two‐dimensional difference gel electrophoresis (2‐D DIGE) investigate memory‐specific changes hippocampal dentate gyrus at increasing times following spatial learning. We identified 42 proteins that were significantly...
Minimally invasive surgery is gaining support for resection of gallbladder cancer (GBC). This study aims to compare operative and early outcomes robotic (RR) open (OR) from a single institution performing high volume HPB surgery.Twenty patients with GBC underwent RR January 2013 August 2019. Outcomes were compared historical control 23 OR. Radical cholecystectomy suspected completion operations incidental after routine both included.Robotic had lower blood loss OR (150 vs 350 mL, P = .002)...