A5081053863- Hearing Loss and Rehabilitation
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Ear Surgery and Otitis Media
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Ultrasound Imaging and Elastography
- MRI in cancer diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Facial Nerve Paralysis Treatment and Research
- Intracranial Aneurysms: Treatment and Complications
- Adrenal and Paraganglionic Tumors
- Vestibular and auditory disorders
- Cerebrovascular and Carotid Artery Diseases
- Epilepsy research and treatment
- Acute Ischemic Stroke Management
- Medical Practices and Rehabilitation
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Noise Effects and Management
- Spinal Fractures and Fixation Techniques
Universitätsklinikum Erlangen
2019-2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2023
ORCID
2022
Genome-wide association studies (GWAS) associated Family with sequence similarity 13, member A (FAM13A) non-small cell lung cancer (NSCLC) occurrence. Here, we found increased numbers of FAM13A protein expressing cells in the tumoral region tissues from a cohort patients NSCLC. Moreover, inversely correlated CTLA4 but directly HIF1α levels control these patients. Consistently, RhoGAP was to be T effector molecules like and Tbet downregulated immunosuppressive CD4+CD25+Foxp3+CTLA4+ cells....
Epilepsy is a common comorbidity of glioblastoma. Seizures may occur in various phases the disease. We aimed to assess potential risk factors for seizures accordance with point time at which they occurred.We retrospectively analyzed medical files adult patients de novo glioblastoma treated our institution between January 2006 and 2020. categorized as preoperative (POS), early postoperative (EPS; before initiation radio[chemo]therapy [RCT]), during radiotherapy (SDR; or <30 days after RCT),...
This study aimed to differentiate primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM) via multimodal MRI featuring radiomic analysis. data sets of patients with histological proven PCNSL GBM were analyzed retrospectively. Diffusion-weighted imaging (DWI) dynamic susceptibility contrast (DSC) perfusion evaluated enhancing intracerebral lesions. Selective (contrast enhanced tumor area the highest mean cerebral blood volume (CBV) value) unselective (contouring whole lesion)...
A prospective preoperative evaluation of 7 T ultra-high-field magnetic resonance imaging (MRI) in patients with suspected pituitary microadenomas for both adenoma detection and intrasellar localization compared 3 MRI was carried out.Patients underwent standardized MRI. distinct qualitative (lesion detection, lesion location) quantitative diameters, T1/T2 signal intensity ratio the to normal gland tissue) analysis performed, along an image quality (IQ) regarding overall IQ, anatomical...
Magnetic resonance imaging (MRI) is a crucial factor in optimal treatment planning for stereotactic radiosurgery. To further the awareness of possible errors MRI, this work aimed to investigate magnitude susceptibility induced MRI distortions intracranial organs at risk (OARs) and test effectiveness actively shimming these distortions.Distortion maps 45 exams 42 patients (18 on 1.5 T scanner, 27 3 scanner) were calculated based high-bandwidth double-echo gradient echo sequence. The...
Sodium enhancement has been demonstrated in multiple sclerosis (MS) lesions.To investigate sodium MRI with and without an inversion recovery pulse acute MS lesions relapse during recovery.Prospective.Twenty-nine relapsing-remitting patients were included.A 3D density-adapted radial sequence at 3 T using a dual-tuned (23 Na/1 H) head coil.Full-brain images of the tissue concentration (TSC1, n = 29) (SIR1, 20) beginning anti-inflammatory therapy on medium-term follow-up visits (days 27-99, 12...
Reports about laryngeal trauma and fractures of the hyoid bone are rare in literature. Most cases forensic results postmortem analysis. Traumatic larynx represent a but important differential diagnosis common symptom hoarseness. A 60-year-old female patient presented with unclear dysphonia globus sensation following intubation for surgical treatment lower leg fracture after bicycle accident two months ago. Endoscopy computed tomography (CT) neck revealed fixed immobile fractured piece...
Treated cerebral aneurysms (IA) require follow-up imaging to ensure occlusion. Metal artifacts complicate radiologic assessment. Our aim was evaluate an innovative metal-artifact-reduction (iMAR) algorithm for flat-detector computed tomography angiography (FD-CTA) regarding image quality (IQ) and detection of aneurysm residua/reperfusion in comparison 2D digital subtraction (DSA). Patients with IAs treated by endovascular coiling or clipping underwent both FD-CTA DSA. datasets were...
The aims of this study were to compare speech recognition at different postoperative times for both ears in bilaterally implanted patients and assess the influence time deafness, frequency-to-place mismatch, angular insertion depth (AID) separation between neighbouring electrode contacts on audiometric outcomes.This was performed an academic tertiary referral centre. A total 19 adult (6 men, 13 women), who received sequential bilateral implantation with lateral wall arrays, analysed...
Traumatic, isolated oculomotor nerve palsy is a rare clinical finding and only few reports demonstrate associated magnetic resonance imaging (MRI) findings. Here, we present the case of 70-year-old woman with left-sided following mild head trauma due to an e-bike accident. Post-traumatic cerebral computed tomography revealed punctiform hemorrhage in left interpeduncular cistern MRI confirmed intraneural nerve. Nine weeks later, follow-up showed progressive atrophy contrast-enhancement To...
To compare 7 T magnetic resonance imaging (MRI) of pituitary macroadenomas (PMA) with standard MRI and intraoperative findings regarding tumor detection, localization, size, extension. Patients suspected adenoma underwent pre-operative 1.5 or 3 MRI; 14 patients a PMA were included. A qualitative (lesion location, cavernous sinus infiltration) quantitative depth analysis T, was performed compared findings. Both 1.5/3 enabled the detection all PMAs; lesion size determination equal. enables...
Abstract Background Artifacts from surrounding bony structures, especially the petrous bones, regularly impair soft tissue computed tomography (CT) imaging of middle and posterior fossa. This affects flat-panel CT in particular. Sinusoidal movement C‑arm during acquisition (i.e. craniocaudal tilting along with semicircular rotation) is supposed to reduce artifacts, thus enhancing quality. Methods In work-up ischemic stroke or subarachnoid hemorrhage 40 patients underwent multi-slice (MS-CT)...
Flat-detector computed tomography (FD-CT) is the standard for cochlear implant (CI) imaging. FD-CT systems differ in technical characteristics. Our aim was an evaluation of two different generations with protocols and hardware regarding image quality, radiation dose, scan time.Two temporal bone specimens (- / + CI = TB0/TB1) were scanned using three scanners: scanning (standard FD-CT: 20 s 70 kV, 109 kV; high-speed [HS-FD-CT]: 7 9 14 72 kV) MS-CT (5 120 kV). Acquired datasets evaluated...
Abstract Purpose Endovascular therapy (EVT) of large-vessel occlusion in acute ischemic stroke (AIS) may be performed general anesthesia (GA) or conscious sedation (CS). We intended to determine the contribution cerebral lesion sites on physician’s decision between GA and CS using voxel-based symptom mapping (VLSM). Methods In a prospective local database, we sought patients with documented AIS EVT. Age, severity, volume, vigilance, aphasia scores were compared EVT CS. The lesions analyzed...
To evaluate single- and multiparametric MRI models to differentiate recurrent glioblastoma (GBM) treatment-related changes (TRC) in clinical routine imaging. Selective unselective apparent diffusion coefficient (ADC) minimum, mean, maximum cerebral blood volume (CBV) measurements the lesion were performed. Minimum, ratiosCBV (CBVlesion CBVhealthy white matter) computed. All data tested for discrimination. A model was compiled via multiple logistic regression using demonstrating significant...
Received: 29 April 2022 Accepted after revision: 22 June Article published online:13 2023
70-80% of all cerebellopontine angle tumors are vestibular schwannomas. The incidence is 0.9-2.4%. Intralabyrinthine schwannomas (ILS) should be mentioned as a small subgroup. In turn, 50% ILS intracochlear – with the most common symptom sudden hearing loss. question best possible therapy for these growing arises again and again. not underestimated, especially due to increase diagnostic options using high-resolution MRI images. early resection simultaneous Cochler Implant treatment seems...