A5041953637- Glaucoma and retinal disorders
- Cervical Cancer and HPV Research
- Corneal surgery and disorders
- Laser Applications in Dentistry and Medicine
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- Corneal Surgery and Treatments
- Optical Imaging and Spectroscopy Techniques
- Genital Health and Disease
- Ocular Surface and Contact Lens
- Dental Radiography and Imaging
- Orthodontics and Dentofacial Orthopedics
- Head and Neck Cancer Studies
- Machine Learning and Data Classification
- Retinal and Optic Conditions
- Temporomandibular Joint Disorders
- Neural Networks and Applications
- Photoacoustic and Ultrasonic Imaging
- Face and Expression Recognition
- Facial Trauma and Fracture Management
- Anatomy and Medical Technology
- Spectroscopy Techniques in Biomedical and Chemical Research
- Dental Anxiety and Anesthesia Techniques
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Universitätsklinikum Erlangen
2019-2024
Zimmer Biomet (Germany)
2010-2022
Bayreuth Medical Center
2021
University of Cologne
2016
World Water Watch
2016
University Hospital Cologne
2016
Christie's
2016
University Medical Center Hamburg-Eppendorf
2012
Universität Hamburg
2012
4008 Background: Chemotherapy (CT) is the standard of care in nonresectable locally advanced pancreatic cancer. The CONKO-007 trial studied role sequential CT and chemoradiotherapy (CRT). Methods: In this randomized multicenter phase III resectability was judged by an independent surgical board. Patients (pts) received induction chemotherapy (IC) for 3 months (3 cycles gemcitabine (Gem, 1000 mg/m² d1, 8, 15, q4w) or FOLFIRINOX (6 cycles, q2w)). After IC pts without progression were to either...
Combining multiple classifiers, known as ensemble methods, can give substantial improvement in prediction performance of learning algorithms especially the presence non-informative features data sets. We propose an subset kNN ESkNN, for classification task two steps. Firstly, we choose classifiers based upon their individual using out-of-sample accuracy. The selected are then combined sequentially starting from best model and assessed collective on a validation set. use bench mark sets with...
Sufficient data are not currently available on how the various geometries of scan bodies and different strategies affect quality digital impressions implants. The purpose this study was to present new these two topics give clinicians a basis for decision making.A titanium master model containing three Nobelreplace Select™ implants (Nobelbiocare Services AG, Zurich, Switzerland) digitized using an ATOS industrial noncontact scanner. Digitization repeated times with types integrated into...
The predictive performance of a random forest ensemble is highly associated with the strength individual trees and their diversity. Ensemble small number accurate diverse trees, if prediction accuracy not compromised, will also reduce computational burden. We investigate idea integrating that are diverse. For this purpose, we utilize out-of-bag observations as validation sample from training bootstrap samples, to choose best based on then assess these for diversity using Brier score an...
Abstract Aim This study evaluates the early volumetric changes after buccal soft tissue contour augmentation around implants with a porcine collagen matrix (CM) vs. subepithelial connective graft (SCTG) from palate. Materials and methods 14 patients were enrolled implant placement simultaneous persistent deficits. At exposure, tissues thickened CM ( n = 7) or SCTG 7). Impressions taken before surgery, ten days, one, three six months. digitized augmented regions 3D evaluated (soft volume (mm...
Abstract Aims To examine symptoms of depression and generalised anxiety among nurses over 2 years during the pandemic compare them to general population. Background The COVID‐19 has led a significant increase in mental stress population worldwide. Nursing staff have been identified as being under remarkable strain. Design A multicentre prospective longitudinal study. Methods Symptoms 507 were examined at four different time points (T1: April–July 2020, T2: November 2020–January 2021, T3:...
Cervical intraepithelial neoplasia (CIN) III/high-grade squamous lesions (HSIL) remains a significant challenge during pregnancy. Current data on the course of disease are contradictory, with cases progression to cervical cancer (CC) pregnancy being observed. Evidence suggests that expression L1 capsid protein is associated favorable prognosis in non-pregnant women. The aim this study was evaluate pregnant women CIN III/HSIL. Between 2008 and 2021, conventional PAP-smears from were...
The feasibility of shifted-excitation Raman difference spectroscopy (SERDS) as a label-free and non-invasive technique for an objective diagnosis oral cancer (OSCC) was investigated by analyzing 12 ex vivo OSCC samples.72 mean SERDS spectra from each three physiological tissue points pathological lesions were correlated with the histo-pathological diagnosis.Principal component analysis (PCA) linear discriminant (LDA) showed excellent results area under curve 94.5% classification error 9.7%...
Purpose: The purpose of this study was to assess the diagnostic power novel two-dimensional parameter Bruch's membrane opening minimal rim area (BMO-MRA) in spectral-domain optical coherence tomography (SD-OCT) for detection glaucoma compared width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness large small optic discs. Methods: In case-control, cross-sectional study, 207 eyes participants, including 89 controls 97 patients with 21 ocular hypertension (OHT), a disc size <1.63 mm2 or...
Chemotherapy with or without radiotherapy is the standard in patients initially nonmetastatic unresectable pancreatic cancer. Additional surgery discussion. The CONKO-007 multicenter randomized trial examines value of radiotherapy. Our interim analysis showed a significant effect surgery, which may be relevant to clinical practice.One hundred eighty received induction chemotherapy (gemcitabine FOLFIRINOX). Patients tumor progression were either alone concurrent chemoradiotherapy. At end...
The effect of training data size on machine learning methods has been well investigated over the past two decades. predictive performance tree based methods, in general, improves with a decreasing rate as increases. We investigate this optimal trees ensemble (OTE) where method fails to learn from some observations due internal validation. Modified selection are thus proposed for OTE cater loss In first method, corresponding out-of-bag (OOB) used both individual and collective assessment each...
Abstract Objective In dental restorations, color determination is very important for achieving esthetic results. The aim of this study was to compare visual shade selection using digital methods and assess the repeatability utilized intraoral scanners. Materials 31 probands, tooth determined on teeth 11, 13, 16. Shade performed visually by a dentist digitally Trios 3 Cerec Omnicam. Three measurements were determine Fleiss' κ used statistical evaluation Cohen's comparison methods. Results...
Abstract Background This longitudinal, multicenter web-based study explored the trajectories of depressive and anxiety symptoms during COVID-19 pandemic among physicians over two years. Methods At four measurement points between 4/2020 5/2022 (Patient Health Questionnaire-2, PHQ-2) (Generalized Anxiety Disorder Scale-2, GAD-2) in German hospitals were assessed. Time, gender age effects analyzed with linear mixed regression models. Comparisons norm values for population also performed...
Chronic stress is a risk factor for developing stress-induced mental disorders like major depression and post-traumatic disorder. Low-grade inflammatory processes seem to mediate this association. The sphingolipid metabolism with its most important lipid messengers ceramide sphingosine-1-phosphate (S1P) was shown play an role in the pathophysiology of affective inflammation. We conducted exploratory trial investigate effect intensive psychosomatic - psychotherapeutic treatment on biological...
To analyze whether tumor-associated lymphangiogenesis is concurrent with the progression of premalignant conjunctival melanocytic intraepithelial neoplasia (C-MIN) into invasive melanoma (CM) and to study its association prognosis.Twenty patients CM were closely matched 20 C-MIN atypia without regarding tumor size, location, extension, patient's age. All specimens analyzed for immunohistochemical presence proliferating lymphatic vessels, LYVE-1 podoplanin used as specific endothelial markers...
Abstract Purpose To characterize the two‐dimensional parameter Bruch's membrane opening minimum rim area ( BMO ‐ MRA ) in spectral domain optical coherence tomography SD OCT of optic nerve head ONH compared to width MRW and retinal fibre layer RNFL thickness a large patient cohort. Methods Case–control, cross‐sectional study 705 eyes 445 participants. A total 449 with glaucoma, 67 ocular hypertension 189 healthy controls, underwent confocal laser scanning CSLT ), visual field testing...
<h3>Purpose</h3> To assess the performance of Bruch9s membrane opening (BMO)-based spectral domain optical coherence tomography (SD-OCT) optic nerve head for glaucoma detection in microdiscs comparison with confocal scanning laser (CSLT). <h3>Design</h3> Retrospective cohort study. <h3>Methods</h3> 82 eyes patients disc size <1.63 mm<sup>2</sup> underwent SD-OCT and CSLT measurements, visual field testing clinical examination. BMO-based minimal rim width (BMO-MRW), retinal fibre layer...