A5053400883- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Glaucoma and retinal disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- MRI in cancer diagnosis
- Multiple Sclerosis Research Studies
- Stroke Rehabilitation and Recovery
- Glioma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Optical Imaging and Spectroscopy Techniques
- Epilepsy research and treatment
- Neurosurgical Procedures and Complications
- Ophthalmology and Eye Disorders
- Retinal Imaging and Analysis
- Cerebral Venous Sinus Thrombosis
- Neuroscience and Neuropharmacology Research
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Neurological Complications and Syndromes
- Atrial Fibrillation Management and Outcomes
Universitätsklinikum Erlangen
2015-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2024
XinHua Hospital
2022
Bayer (Germany)
2020
University of California, San Francisco
2016
Siemens Healthcare (Germany)
2011
University of Wisconsin–Madison
2011
Siemens (Germany)
2010
UW Health University Hospital
2010
Heliophysics
2010
BACKGROUND: The optimal management of patients with isolated posterior cerebral artery occlusion is uncertain. We compared clinical outcomes for endovascular therapy (EVT) versus medical (MM) in occlusion. METHODS: This multinational case-control study conducted at 27 sites Europe and North America included consecutive presenting within 24 hours time last well from January 2015 to August 2022. Patients treated EVT or MM were multivariable logistic regression inverse probability treatment...
<h3>BACKGROUND AND PURPOSE:</h3> The viability of both brain parenchyma and vascular anatomy is important in estimating the risk potential benefit revascularization patients with acute cerebral ischemia. We tested hypothesis that when used conjunction IV contrast, FD-CT imaging would provide anatomic physiologic information correlate well obtained by using standard multisection CT techniques. <h3>MATERIALS METHODS:</h3> Imaging (FD-CT), vasculature (FD-CTA), blood volume (FD-CBV) was...
The glutamate transporter xCT (SCL7a11, system Xc-, SXC) is an emerging key player in glutamate/cysteine/glutathione homeostasis the brain and cancer. expression correlates with grade of malignancy. Here, we report on use U.S. Food Drug Administration EMA-approved inhibitor, sulfasalazine (SAS) gliomas. SAS does not affect cell viability gliomas at concentrations below 200 µM. At higher becomes gliomatoxic. Mechanistically inhibits induces ferroptotic death glioma cells. There no evidence...
Acute ischemic stroke with isolated posterior cerebral artery occlusion (iPCAO) lacks management evidence from randomized trials. We aimed to evaluate whether the association between endovascular treatment (EVT) and outcomes in iPCAO acute is modified by initial severity (baseline National Institutes of Health Stroke Scale [NIHSS]) arterial site.
Background and Purpose Posterior cerebral artery occlusion (PCAo) can cause long-term disability, yet randomized controlled trials to guide optimal reperfusion strategy are lacking. We compared the outcomes of PCAo patients treated with endovascular thrombectomy (EVT) or without intravenous thrombolysis (IVT) IVT alone.Methods From multicenter retrospective cerebraL ArTery Occlusion (PLATO) registry, we included isolated therapy within 24 hours onset between January 2015 August 2022. The...
Endoluminal reconstruction with flow-diverting stents represents a widely accepted technique for the treatment of complex intracranial aneurysms. This European registry study analyzed initial experience 15 neurovascular centers Flow-Redirection Intraluminal Device (FRED) system.Consecutive patients aneurysms treated FRED between February 2012 and March 2015 were retrospectively reviewed. Complications adverse events, transient permanent morbidity, mortality, occlusion rates evaluated.During...
Background and Purpose— In patients with ischemic stroke on therapy vitamin K antagonists, severity clinical course are affected by the quality of anticoagulation at time onset, but data for using direct oral anticoagulants (DOACs) limited. Methods— Data from our registry including all admitted acute cerebral ischemia while taking atrial fibrillation between November 2014 October 2017 were investigated. The activity antagonists was assessed international normalized ratio admission...
We aimed to assess the prevalence of ischemic brain lesions detected by magnetic resonance imaging and their association with cognitive function 3 months after first-time ablation using continuous oral anticoagulation in patients paroxysmal atrial fibrillation (AF).We performed a prespecified analysis AXAFA-AFNET 5 trial (Anticoagulation Using Direct Factor Xa Inhibitor Apixaban During Atrial Fibrillation Catheter Ablation: Comparison Vitamin K Antagonist Therapy), which randomized 674 AF...
The goal of the present study was to test impact administration time angiotensin II type 1-receptor blocker candesartan on cerebral blood flow (CBF), infarct size, and neuroscore in transient ischemia. Therefore, 1-hour middle artery occlusion (MCAO) followed by reperfusion. Rats received 0.5-mg/kg intravenously 2 hours before MCAO (pretreatment), 24 after MCAO, every or MCAO. Infarct size (mm3) a at day 7 were compared with controls. CBF quantified radiolabeled microspheres laser-Doppler...
Thrombolytic therapy is frequently withheld in patients with minor stroke symptoms. However, recent studies demonstrate that a substantial proportion of these dies or remains permanently disabled because underestimation symptom severity at baseline secondary deterioration. We aimed to assess the safety and outcome thrombolysis but disabling symptoms.32 presenting mild symptoms were treated intravenous recombinant tissue-type plasminogen activator between April 2006 2008. Data extracted from...
Brain edema is a hallmark of human malignant brain tumors and contributes to the clinical course outcome tumor patients. The so-called perifocal or swelling imposes in T2-weighted MR scans as high intensity areas surrounding bulk mass. mechanisms this increased fluid attraction cellular composition microenvironment are only partially understood. In study, we focus on imaging orthotopically implanted gliomas rodents correlate with immunohistochemical markers. We identified that not include...
<b>BACKGROUND AND PURPOSE:</b> The purpose of this work was to evaluate angiographic CT (ACT) in the combined application a self-expanding neurovascular stent and detachable platinum coils management broad-based fusiform intracranial aneurysms. <b>MATERIALS METHODS:</b> Eleven patients harboring wide-necked aneurysms were treated with flexible subsequent aneurysm embolization microcoils. ACT performed after interventional procedure analyze position relationship stent. Postprocessing included...