Johannes Trenkler
A5031560071- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Stroke Rehabilitation and Recovery
- Glioma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Blood Coagulation and Thrombosis Mechanisms
- Meningioma and schwannoma management
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- CNS Lymphoma Diagnosis and Treatment
- Epilepsy research and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- MRI in cancer diagnosis
- Fetal and Pediatric Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Anatomy and Medical Technology
- Cardiovascular Health and Disease Prevention
- Neurological Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Genetic Neurodegenerative Diseases
- Privacy-Preserving Technologies in Data
Kepler Universitätsklinikum
2016-2024
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2023-2024
Johannes Kepler University of Linz
2013-2023
Health and Education Research Management and Epidemiologic Services (United States)
2023
Stanford University
2021-2022
Klinikum Wels-Grieskirchen
2021
Neurological Surgery
2021
Universität Hamburg
2007-2021
University Medical Center Hamburg-Eppendorf
2007-2021
University Hospital of Basel
2020
A study was undertaken to evaluate clinical and procedural factors associated with outcome recanalization in endovascular stroke treatment (EVT) of basilar artery (BA) occlusion.ENDOSTROKE is an investigator-initiated multicenter registry for patients undergoing EVT. This analysis includes 148 consecutive BA occlusion, 59% having received intravenous thrombolysis prior Recanalization (defined as Thrombolysis Cerebral Infarction [TICI] score 2b-3) collateral status (using the American Society...
Although machine learning (ML) has shown promise in numerous domains, there are concerns about generalizability to out-of-sample data. This is currently addressed by centrally sharing ample, and importantly diverse, data from multiple sites. However, such centralization challenging scale (or even not feasible) due various limitations. Federated ML (FL) provides an alternative train accurate generalizable models, only numerical model updates. Here we present findings the largest FL study...
Background and Purpose— There has been speculation that the risk of secondary symptomatic intracranial hemorrhage (SICH) may be increased after thrombolytic therapy in ischemic stroke patients who have cerebral microbleeds (CMBs) on T2*-weighted magnetic resonance imaging. Because this concern, some centers withhold potentially beneficial from these patients. Methods— We analyzed imaging data acquired within 6 hours symptom onset 570 treated with intravenous tissue plasminogen activator 13...
Carotid stent cell design has recently been suggested to be a determinant of periprocedural and early postprocedural neurologic complications. We investigated the impact closed- versus open-cell on adverse events mortality after carotid artery stenting.We studied 1684 consecutive patients (1010 asymptomatic, 674 symptomatic) from 10 European centers who underwent stenting with either closed-cell (n=859, 51%) or (n=825, 49%) stents. Rates transient ischemic attack, stroke, death day procedure...
<h3>Importance</h3> Randomized clinical trials have shown the efficacy of thrombectomy large intracranial vessel occlusions in adults; however, any association therapy with outcomes children is unknown. <h3>Objective</h3> To evaluate use endovascular recanalization pediatric patients arterial ischemic stroke. <h3>Design, Setting, and Participants</h3> This retrospective, multicenter cohort study, conducted from January 1, 2000, to December 31, 2018, analyzed databases 27 stroke centers...
In patients with large ischemic stroke, thrombectomy within 12 hours after onset was superior to best medical treatment in reducing 90-day functional disability irrespective of the collateral status on single-phase CT angiography images.
Stereolithographic (SL) biomodeling is a new technology that allows three-dimensional (3D) imaging data to be used in the manufacture of accurate solid plastic replicas anatomical structures. The authors describe their experience with patient series which this relatively visualization method was surgery for cerebral aneurysms. Using rapid prototyping stereolithography, 13 biomodels aneurysms parent and surrounding vessels were manufactured based on 3D computerized tomography scans (three...
<b><i>Background:</i></b> Clinical outcome after endovascular stroke therapy (EVT) for proximal anterior circulation is often disappointing despite high recanalization rates. The ENDOSTROKE study aims to determine predictors of clinical in patients undergoing EVT. Here we focus on the impact age and middle cerebral artery (M1-MCA) or carotid T occlusion. <b><i>Methods:</i></b> an investigator-initiated, industrially independent multicenter...
Endoluminal reconstruction with flow-diverting stents represents a widely accepted technique for the treatment of complex intracranial aneurysms. This European registry study analyzed initial experience 15 neurovascular centers Flow-Redirection Intraluminal Device (FRED) system.Consecutive patients aneurysms treated FRED between February 2012 and March 2015 were retrospectively reviewed. Complications adverse events, transient permanent morbidity, mortality, occlusion rates evaluated.During...
Objective To assess the clinical safety and efficacy of Atlas microstent in stent-assisted coil embolization wide-necked intracranial aneurysms. Methods Single-center observational study 36 patients (24 female, 12 male, mean age 56 years) with 37 aneurysms for endovascular treatment After giving informed consent, were included according to following criteria: aneurysm dome-to-neck ratio <2 or neck diameter >4 mm, a parent vessel ≤4.5 mm. Primary endpoint was absence death, major minor...
The only randomized data on heparin treatment in acute cerebral sinus venous thrombosis (CSVT) are derived from a small number of patients. rate intracranial hemorrhages as complication high-dose is still unknown. This retrospective study evaluates the clinical features, neuroimaging monitoring and outcome 42 patients with proven CSVT. Diagnosis was established by DSA, CT, MR tomography angiography. All received intravenously guided doubling aPTT value for 3 weeks, followed oral...
Stenting is increasingly used as an adjunct to medical therapy in symptomatic intracranial stenoses. High periprocedural adverse event rates are one of the limitations endovascular treatment. Data from INTRASTENT multicentric registry should demonstrate in-hospital complications at current stage clinical development stent procedure.Participating centers entered records all their consecutive procedures into database. To determine outcome acute phase, we distinguished transient ischemic...
Introduction The direct aspiration first pass technique (ADAPT) has been introduced as a rapid and safe endovascular treatment strategy in patients with ischemic stroke. Objective To determine the technical feasibility, safety, functional outcome ADAPT using new large-bore 6F SOFIA Plus catheter. Methods A retrospective analysis of prospectively collected data from six university hospitals was performed. following parameters all acute stroke procedures (June 2015– January 2016) catheter were...
For patients with symptomatic carotid stenosis, benefit from artery stenting (CAS) highly depends on the 30‐day stroke and death rates. Identification of predictors unfavourable outcome would help guide patient selection. We analysed influence clinical angiographic factors outcomes 77 consecutive who underwent CAS for ≥60% stenosis within 180 days transient ischaemic attack or moderate (modified Rankin Scale score ≤3). The composite end‐point (7.8%) any cause (1.3%) was 9.1%. Patients...
Established process models for knowledge discovery find the domain-expert in a customer-like and supervising role. In field of biomedical research, it is necessary to move domain-experts into center this with far-reaching consequences both their research output itself. paper, we revise established propose new model domain-expert-driven interactive discovery. Furthermore, present infrastructure which adapted demonstrate how can be deeply integrated even highly complex data-mining...
In this study, we assessed the prognostic relevance of temporal muscle thickness (TMT), likely reflecting patient’s frailty, in patients with primary central nervous system lymphoma (PCNSL). 128 newly diagnosed PCNSL TMT was analyzed on cranial magnetic resonance images. Predefined sex-specific cutoff values were used to categorize patient cohort. Survival analyses, using a log-rank test as well Cox models adjusted for further parameters, performed. The risk death significantly increased...
BACKGROUND: Recent randomized trials demonstrated the beneficial effect of endovascular therapy in patients with low Alberta Stroke Program Early Computed Tomography Score. Despite large follow-up infarct volumes, a significantly increased rate good functional outcomes was observed, challenging role volume as predictive imaging marker. This analysis evaluates extent to which effects thrombectomy on are explained by (1) and (2) early neurological status stroke METHODS: TENSION trial conducted...
To determine whether thrombectomy is safe in children up to 24 hours after onset of symptoms when selected by mismatch between clinical deficit and infarct.A secondary analysis the Save ChildS Study (January 2000-December 2018) was performed, including all pediatric patients (<18 years) diagnosed with arterial ischemic stroke who underwent endovascular recanalization at 27 European United States centers. Patients were included if they had a relevant infarct.Twenty median age 10.5...
Background and Purpose- The recent Save ChildS study provides multicenter evidence for the use of mechanical thrombectomy in children with large vessel occlusion arterial ischemic stroke. However, device selection may influence rates recanalization, complications, neurological outcomes, especially pediatric patients different ages. We, therefore, performed additional analyses data to investigate a possible association techniques devices angiographic clinical outcome parameters. Methods-...
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