A5030203098- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Advanced X-ray and CT Imaging
- Prostate Cancer Treatment and Research
- Advances in Oncology and Radiotherapy
- Lung Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Mathematical Biology Tumor Growth
- Cancer Immunotherapy and Biomarkers
- Radiation Dose and Imaging
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- AI in cancer detection
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Nuclear reactor physics and engineering
- Cancer Research and Treatments
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Advanced MRI Techniques and Applications
- Health and Medical Research Impacts
University of Wisconsin–Madison
2016-2025
University of Wisconsin Carbone Cancer Center
2016-2025
Jožef Stefan Institute
2012-2025
University of Ljubljana
2016-2025
IQ Solutions
2019-2022
Wisconsin Institutes for Discovery
2016-2022
Institute of Oncology Ljubljana
2021
Rigshospitalet
2020
University of Virginia
2020
European Society for Therapeutic Radiology and Oncology
2020
Concurrent treatment with temozolomide and radiotherapy followed by maintenance is the standard of care for patients newly diagnosed glioblastoma. Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor A, currently approved recurrent Whether addition bevacizumab would improve survival among glioblastoma not known.
Background. Characterization of textural features (spatial distributions image intensity levels) has been considered as a tool for automatic tumor segmentation. The purpose this work is to study the variability in PET images due different acquisition modes and reconstruction parameters. Material methods. Twenty patients with solid tumors underwent PET/CT scans on GE Discovery VCT scanner, 45–60 minutes post-injection 10 mCi [18F]FDG. Scans were acquired both 2D 3D modes. For each raw data...
The purpose of this educational report is to provide an overview the present state-of-the-art PET auto-segmentation (PET-AS) algorithms and their respective validation, with emphasis on providing user help in understanding challenges pitfalls associated selecting implementing a PET-AS algorithm for particular application.A brief description different types provided using classification based method complexity type. advantages limitations current are highlighted publications existing...
Although machine learning (ML) has shown promise in numerous domains, there are concerns about generalizability to out-of-sample data. This is currently addressed by centrally sharing ample, and importantly diverse, data from multiple sites. However, such centralization challenging scale (or even not feasible) due various limitations. Federated ML (FL) provides an alternative train accurate generalizable models, only numerical model updates. Here we present findings the largest FL study...
Helical tomotherapy is a dedicated intensity modulated radiation therapy (IMRT) system with on-board imaging capability (MVCT) and therefore differs from conventional treatment units. Different design goals resulted in some distinctive field characteristics. The most significant differences the are lack of flattening filter, increased shielding collimators, operation modes narrow fan beam delivery. Radiation characteristics helical system, sensitivity studies various incident electron...
PET-based treatment response assessment typically measures the change in maximum standardized uptake value (SUV<sub>max</sub>), which is adversely affected by noise. Peak SUV (SUV<sub>peak</sub>) has been recommended as a more robust alternative, but its associated region of interest (ROI<sub>peak</sub>) not uniquely defined. We investigated impact different ROI<sub>peak</sub> definitions on quantification SUV<sub>peak</sub> and tumor response. <b>Methods:</b> Seventeen patients with solid...
1 The full, final text of this abstract will be available at abstract.asco.org 7:30 AM (EDT) on Sunday, June, 2, 2013, and in the Annual Meeting Proceedings online supplement to June 20, issue Journal Clinical Oncology. Onsite Meeting, printed Sunday edition ASCO Daily News.
Inherent to helical tomotherapy is a dose variation pattern that manifests as “ripple” (peak‐to‐trough relative the average). This ripple result of beam junctioning, completely unique tomotherapy. Pitch defined in CT, couch travel distance for complete gantry rotation axial width at axis rotation. Without scattering or divergence, an analytical posing problem simple integral predicts minima near pitch where integer. A convolution‐superposition calculator (TomoTherapy, Inc.) included all...
Lung cancer, the most commonly diagnosed cancer worldwide, usually presents as solid pulmonary nodules (SPNs) on early diagnostic images. Classification of malignant disease at this timepoint is critical for improving success surgical resection and increasing 5-year survival rates. 18F-fluorodeoxyglucose (18F-FDG) PET/CT has demonstrated value SPNs diagnosis with high sensitivity to detect SPNs, but lower specificity in diagnosing populations endemic infectious lung disease. This study aimed...
<sup>18</sup>F-NaF, a PET radiotracer of bone turnover, has shown potential as an imaging biomarker for assessing the response metastases to therapy. This study aimed evaluate repeatability <sup>18</sup>F-NaF PET–derived SUV metrics in individual lesions from patients multicenter study. <b>Methods:</b> Thirty-five castration-resistant prostate cancer with multiple underwent 2 whole-body (test–retest) PET/CT scans 3 ± d apart 1 sites. A total 411 larger than 1.5 cm<sup>3</sup> were...
Abstract Background Immune checkpoint inhibitors have changed the paradigm of cancer treatment; however, non-invasive biomarkers response are still needed to identify candidates for non-responders. We aimed investigate whether immunotherapy [ 18 F]FDG PET radiomics signature (iRADIOMICS) predicts metastatic non-small-cell lung (NSCLC) patients pembrolizumab better than current clinical standards. Patients and methods Thirty receiving were scanned with PET/CT at baseline, month 1 4....
We previously reported the safety and immunologic effects of a DNA vaccine (pTVG-HP [MVI-816]) encoding prostatic acid phosphatase (PAP) in patients with recurrent, nonmetastatic prostate cancer. The current trial evaluated this on metastatic progression.Ninety-nine castration-sensitive cancer prostate-specific antigen (PSA) doubling time (DT) less than 12 months were randomly assigned to treatment either pTVG-HP co-administered intradermally 200 μg granulocyte-macrophage colony-stimulating...
To automatically detect lymph nodes involved in lymphoma on fluorine 18 (18F) fluorodeoxyglucose (FDG) PET/CT images using convolutional neural networks (CNNs).In this retrospective study, baseline disease of 90 patients with was segmented 18F-FDG (acquired between 2005 and 2011) by a nuclear medicine physician. An ensemble three-dimensional patch-based, multiresolution pathway CNNs trained fivefold cross-validation. Performance assessed the true-positive rate (TPR) number false-positive...
Positron emission tomography (PET) plays an increasingly important role in research and clinical applications, catalysed by remarkable technical advances a growing appreciation of the need for reliable, sensitive biomarkers human function health disease. Over last 30 years, large amount physics engineering effort PET has been motivated dominant application during that period, oncology. This led to developments such as PET/CT, whole-body PET, 3D accelerated statistical image reconstruction,...
In routine clinical practice, radiotherapy treatment planning is performed based on the patient CT images obtained during setup procedure. However, actual delivered dose to might be different from planned because of various reasons such as motion. Under situations, it desirable modify original plan in order partially remedy delivery errors subsequent process. Such modification can implemented by modifying using re-optimization. this work, issues re-optimization prescription, optimization...
Understanding the limitations of Monte Carlo codes is essential in order to avoid systematic errors simulations, and suggest further improvement codes. MCNP EGS4, commonly used medical physics, were compared evaluated against electron depth dose data experimental backscatter results obtained using clinical radiotherapy beams. Different physical models algorithms give significantly different curves backscattering factors. The default version calculates which are too penetrating. agree better...
A criticality benchmark experiment performed at the Jozef Stefan Institute TRIGA Mark II research reactor is described. This and its evaluation are given as examples of experiments reactors. For this reason differences possible problems compared to other particularly emphasized. General guidelines for performing benchmarks in reactors given. The was a normal operating core using commercially available fresh 20% enriched fuel elements containing 12 wt% uranium uranium-zirconium hydride...
The effect of dose calculation accuracy during inverse treatment planning for intensity modulated radiotherapy (IMRT) was studied in this work. Three methods were compared: Monte Carlo, superposition and pencil beam. These algorithms used to calculate beamlets, which subsequently by a simulated annealing algorithm determine beamlet weights comprised the optimal solution objective function. different cases (lung, prostate head neck) investigated several functions tested their on planning. It...
GS-9219, a novel prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG), was designed as cytotoxic agent that preferentially targets lymphoid cells. Our objective to characterize antiproliferative activity, pharmacokinetics, pharmacodynamics, and safety GS-9219.GS-9219 selected through screening in proliferation assays pharmacokinetic screening. The activation pathway GS-9219 characterized lymphocytes, its activity evaluated against panel hematopoietic nonhematopoietic...