A5075883320- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Radiation Dose and Imaging
- Nuclear Physics and Applications
- Alzheimer's disease research and treatments
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Atomic and Subatomic Physics Research
- Radiation Effects in Electronics
- Muon and positron interactions and applications
- Digital Radiography and Breast Imaging
- Medical Image Segmentation Techniques
- Pancreatic and Hepatic Oncology Research
- Glioma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Brain Tumor Detection and Classification
- Aortic Disease and Treatment Approaches
National Institutes for Quantum Science and Technology
2017-2025
Kobe City Medical Center General Hospital
2016-2023
Foundation for Biomedical Research and Innovation
2013-2019
Laboratoire d’Imagerie Biomédicale
2017
Kyushu University
2012-2016
Department of Medical Sciences
2013-2015
The aim of this study was to investigate the effects point-spread function (PSF) and time-of-flight (TOF) on improving <sup>18</sup>F-FDG PET/CT images in relation reconstruction parameters noise-equivalent counts (NEC). <b>Methods:</b> This consisted a phantom retrospective analysis 39 consecutive patients who underwent clinical PET/CT. body National Electrical Manufacturers Association International Electrotechnical Commission with 10-mm-diameter sphere filled an solution 4:1 radioactivity...
Standardized uptake values (SUVs) have been widely used in the diagnosis of malignant tumors and clinical trials tumor therapies as semiquantitative metrics <sup>18</sup>F-FDG uptake. However, SUVs for small lesions are liable to errors due partial-volume effect statistical noise. The purpose this study was evaluate reproducibility accuracy maximum peak SUV (SUV<sub>max</sub> SUV<sub>peak</sub>, respectively) phantom experiments. <b>Methods:</b> We a body with 6 spheres quarter warm...
Positron emission tomography (PET) plays an increasingly important role in research and clinical applications, catalysed by remarkable technical advances a growing appreciation of the need for reliable, sensitive biomarkers human function health disease. Over last 30 years, large amount physics engineering effort PET has been motivated dominant application during that period, oncology. This led to developments such as PET/CT, whole-body PET, 3D accelerated statistical image reconstruction,...
Brain PET, which has led research in molecular imaging and diagnosis of brain cancer, epilepsy neurodegenerative disorders, is being spotlighted again to promote earlier dementia with the advent amyloid tau tracers. To meet this demand, paper, we developed a brain-dedicated PET device hemispherical detector arrangement, provides comparable sensitivity fewer detectors than conventional cylindrical geometries. The introduction time-of-flight (TOF) measurement capability was key point for...
Objective.For PET imaging systems, a smaller detector ring enables less intrinsic spatial resolution loss due to the photon non-collinearity effect as well better balance between production cost and sensitivity, hemispherical arrangement is more appropriate for brain than conventional cylindrical arrangement. Therefore, we have developed brain-dedicated system with arrangement, which has been commercialized in Japan under product name of VRAINTM. In this study, evaluated performance...
Abstract Objective. To compare the accuracy with which different hadronic inelastic physics models across ten Geant4 Monte Carlo simulation toolkit versions can predict positron-emitting fragments produced along beam path during carbon and oxygen ion therapy. Approach. Phantoms of polyethylene, gelatin, or poly(methyl methacrylate) were irradiated monoenergetic beams. Post-irradiation, 4D PET images acquired parent 11 C, 10 C 15 O radionuclides contributions in each voxel determined from...
Abstract PET has become an important clinical modality but is limited to imaging positron emitters. Recently, with 89 Zr, which a half-life of 3 days, attracted much attention in immuno-PET visualize immune cells and cancer by targeting specific antibodies on the cell surface. However, Zr emits single gamma ray at 909 keV four times more frequently than positrons, causing image quality degradation conventional PET. To overcome this drawback, use such rays for was previously proposed as whole...
In positron emission tomography (PET), time-of-flight (TOF) information localizes source positions along lines of response. Cherenkov-radiator-integrated microchannel-plate photomultiplier tubes have achieved 30 ps TOF resolution, demonstrating cross-sectional imaging without reconstruction. Such ultrafast detectors would free PET from conventional ring geometries. Therefore, this study aimed at investigating characteristics a dual-panel with using Geant4 simulation. Two detector panels...
PET is affected by statistical noise due to constraints on tracer dose and scan duration, impacting both diagnostic performance quantitative accuracy. While deep learning (DL)-based denoising methods have been used improve image quality, they may introduce over-smoothing, compromising We propose a method for making DL solution more reliable apply it the conditional prior (DIP). idea of stability information in optimization process DIP, enabling identification unstable regions within...
Abstract Positron emission tomography (PET) is a valuable tool for diagnosing malignant tumors. Intraoperative PET imaging expected to allow the more accurate localization of tumors that need resections. However, conventional devices feature large detector ring obstructs surgical procedures, preventing their intraoperative application. This paper proposes new device, Scratch-PET, image-guided tumor resection. The key Scratch-PET its use hand-held scan field, ensuring open space surgery while...
Abstract Objective The aim of this study was to evaluate the effect point spread function (PSF) and time flight (TOF) on PET/CT images overweight patients in relation iteration number acquisition time. Methods This consisted a phantom clinical study. NEMA IEC body 40 cm diameter large (LG phantom) simulating an patient were used Both phantoms filled with 18 F solution sphere background ratio 4:1. PET data reconstructed baseline ordered-subsets expectation maximization (OSEM) algorithm, OSEM...
While fluorodeoxyglucose (FDG) and amyloid PET is valuable for patient management, research, clinical trial of therapeutics on Alzheimer's disease, the specific details scanning method including camera model type influence image quality, which may further affect interpretation images quantitative capabilities. To make multicenter data reliable to establish as a universal diagnostic technique verified biomarker, we have proposed phantom test procedures criteria optimizing quality across...
Parallax error caused by the detector crystal thickness degrades spatial resolution at peripheral regions of field-of-view (FOV) a scanner. To resolve this issue, depth-of-interaction (DOI) measurement is promising solution to improve and its uniformity over entire FOV. Even though DOI detectors have been used in dedicated systems with small ring diameter such as for human brain, breast animals, use large bore whole-body PET system has not demonstrated yet. We developed four-layered...
Amyloid PET is useful for early and/or differential diagnosis of Alzheimer's disease (AD). Quantification amyloid deposition using has been employed to improve and monitor AD therapy, particularly in research. Although MRI often used segmentation gray matter spatial normalization into standard Montreal Neurological Institute (MNI) space where region-of-interest (ROI) template defined, 3D not always available clinical practice. The purpose this study was examine the feasibility PET-only...
Recent developments in hardware and software for PET technologies have resulted wide variations basic performance. Multicentre studies require a standard imaging protocol SUV harmonization to reduce inter- intra-scanner variability the SUV. The Japanese standardised uptake value (SUV) Harmonization Technology (J-Hart) study aimed determine applicability of vendor-neutral on derived from positron emission tomography (PET) images. effects were evaluated based reproducibility several scanners...
In advanced ion therapy, the visualization of range incident ions in a patient's body is important for exploiting advantages this type therapy. It ideal to use radioactive beams in-beam positron emission tomography (PET) imaging particle therapy due high quality PET images caused by signal-to-noise ratio. We have shown feasibility idea through an study 11C and 15O using dedicated OpenPET system. work, we investigate potential difference between Bragg peak position maximum detected...
The PET image quality of overweight patients and who receive low injected doses deteriorates because increases in statistical noise. purpose this study was to investigate the benefits point-spread function (PSF) time-of-flight (TOF) for PET/CT such patients.The images were reconstructed using baseline ordered-subsets expectation-maximization algorithm (OSEM), OSEM + PSF, TOF, PSF TOF. In phantom study, we used a National Electrical Manufacturers Association body with different radioactivity...