A5038612225- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Intracranial Aneurysms: Treatment and Complications
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Amino Acid Enzymes and Metabolism
- Neuroendocrine Tumor Research Advances
- Cerebrovascular and Carotid Artery Diseases
- Nanoplatforms for cancer theranostics
- Occupational and environmental lung diseases
- Drug Transport and Resistance Mechanisms
- Renal cell carcinoma treatment
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Photodynamic Therapy Research Studies
- Cancer Cells and Metastasis
- Radiation Therapy and Dosimetry
National Institutes for Quantum Science and Technology
2015-2025
Okayama University
2025
Okayama University Hospital
2025
Osaka University of Pharmaceutical Sciences
2025
Iwata City Hospital
2017-2024
Shiga University of Medical Science
2007-2024
Theranostics (New Zealand)
2020-2023
Industrial Research Institute of Ishikawa
2012-2022
Molecular Theranostics (United States)
2021
National Cancer Center Hospital East
2019
In the present study, functional characteristics of organic cation transporter (OCTN)1, which was cloned as pH-dependent tetraethylammonium (TEA) when expressed in mammalian human embryonic kidney (HEK)293 cells, were further investigated using Xenopus oocytes well HEK293 cells gene expression systems. When OCTN1-derived complementary RNA injected into oocytes, transport [14C]TEA observed same cells. contrast, a replacement sodium ions with potassium surrounding medium did not cause any...
The OpenPET geometry is our new idea to visualize a physically opened space between two detector rings. In this paper, we developed the first small prototype show proof-of-concept of imaging. Two rings 110 mm diameter and 42 axial length were placed with gap mm. basic imaging performance was confirmed through phantom studies; open realized at cost slight loss resolution 24% sensitivity. For PET image-guided radiation therapy, carried out in-beam tests 11C radioactive beam irradiation in...
We proposed a concept of whole gamma imaging (WGI) that utilizes all detectable rays for imaging. An additional detector ring, which is used as the scatterer, inserted in field-of-view PET ring so single can be detected by Compton method. In particular, non-pure positron emitters emit an ray almost at same time, triple will enabled; localization on each line-of-response (LOR) possible using cone ray. developed prototype to show proof WGI concept. The diameters scatterer and were set 20 cm 66...
Meltrin α (ADAM12) is a metalloprotease-disintegrin whose specific expression patterns during development suggest that it involved in myogenesis and the of other organs. To determine roles plays vivo, we generated α-deficient mice by gene targeting. Although number homozygous embryos are close to expected Mendelian ratio at embryonic days 17 18, ca. 30% null pups born die before weaning, mostly within 1 week birth. The viable mutants appear normal fertile. Most muscles normal, regeneration...
Fatty acid synthase (FASN) expression is elevated in several cancers, and this over-expression associated with poor prognosis. Inhibitors of FASN, such as orlistat, reportedly show antitumor effects against cancers that over-express making FASN a promising therapeutic target. However, large variations levels individual tumors have been observed, methods to predict FASN-targeted therapy outcome before treatment are required avoid unnecessary treatment. In addition, how inhibition affects...
Therapeutic options for patients with malignant pheochromocytoma are currently limited, and therefore new treatment approaches being sought. Targeted radionuclide therapy provides tumor-specific systemic treatments. The β-emitting radiopharmaceutical meta-131I-iodo-benzylguanidine (131I-MIBG) limited survival benefits has adverse effects. A generation of radionuclides using α-particles including meta-211At-astato-benzylguanidine (211At-MABG) expected to have strong therapeutic effects...
Abstract Positron-emission tomography (PET) and single-photon-emission computed (SPECT) are well-established nuclear-medicine imaging methods used in modern medical diagnoses. Combining PET with 18 F-fluorodeoxyglucose (FDG) SPECT an 111 In-labelled ligand provides clinicians information about the aggressiveness specific types of tumors. However, it is difficult to integrate a system because requires collimator. Herein, we describe novel method that simultaneous nuclides by combining Compton...
Modern Japanese sushi is derived from an archetype, narezushi, which made by the fermentation of salted fish with rice. Several studies have demonstrated that lactic acid bacteria are dominantly present in but no addressed how microbial composition changes during fermentation. In this study, we examined population aji (horse mackerel)-narezushi pyrosequencing 16S ribosomal RNA gene (rDNA). Ribosomal Database Project Classifier analysis revealed among 53 genera present, Lactobacillus...
Despite the pathological importance of fibrin clot formation, little is known about structure these clots because X-ray and nuclear magnetic resonance (NMR) analyses are not applicable to insoluble proteins. In contrast previously reported anti-fibrin monoclonal antibodies (mAbs), our mAb (clone 102–10) recognises an uncovered region that exposed only when a forms. The epitope 102–10 was mapped hydrophobic on Bβ chain interacted closely with counterpart γ in soluble state. New anti-Bβ anti-γ...
The worldwide incidence of the highly aggressive tumor mesothelioma is expected to increase. Mesothelioma classified into three main histological subtypes: epithelioid, sarcomatoid and biphasic. Although pathological diagnostic markers for epithelioid are established, date no adequate marker has been found. Thus, a reliable necessary. In this study, identify an unknown protein with 120 kDa expressed only in cell line 211H, we conducted proteomic analysis found five candidate proteins. One...
Many traditional fermented products are onsumed in Ishikawa Prefecture, Japan, such as kaburazushi, narezushi, konkazuke, and ishiru. Various kinds of lactic acid bacteria (LAB) associated with their fermentation, however, characterization LAB has not yet been elucidated detail. In this study, we evaluated 53 isolates from various foods by taxonomic classification at the species level analyzing 16S ribosomal RNA gene (rDNA) sequences carbohydrate assimilation abilities. We screened that...
Sake is made from steamed rice, malted and water. production begins with the preparation of a small-scale starter (moto); quality moto significantly influences flavor richness sake. In traditional starter, yamahai-moto, growth naturally occurring lactic acid bacteria represses putrefactive micro-organisms, whereas in modern sokujo-moto, this achieved by adding acid. study, successive change bacterial flora yamahai-moto was analyzed pyrosequencing 16S ribosomal RNA genes. Lactobacillus...
The transmembrane cell adhesion receptor αVβ3 integrin (αVβ3) has been identified as an important molecular target for cancer imaging and therapy. We have developed a tetrameric cyclic RGD (Arg-Gly-Asp) peptide-based radiotracer (64)Cu-cyclam-RAFT-c(-RGDfK-)4, which successfully captured αVβ3-positive tumors angiogenesis by PET. Here, we subsequently evaluated its therapeutic potential side effects using established tumor mouse model. Mice with subcutaneous U87MG glioblastoma xenografts...
Abstract Compton imaging or camera has been studied well, but its advantages in nuclear medicine and molecular have not demonstrated yet. Therefore, the aim of this work was to compare with positron emission tomography (PET) by using same platform whole gamma (WGI). WGI is a concept that combines PET inserting scatterer ring into ring. This utilizes diverse types rays for 3D tomographic imaging. In paper, we remodeled our previous prototype small animal imaging, developed an image...
The high therapeutic effect of targeted radioisotope/radionuclide therapy (TRT) using α-emitters, especially 225Ac, is attracting attention worldwide. However, the only 225Ac production method that has been put into practical use extraction from a 229Th generator derived nuclear fuel 233U, and it unlikely this alone able to meet future global medical demand. Development towards new methods in progress. These require irradiation 232Th or 226Ra an accelerator reactor. Global competition...
Abstract PET has become an important clinical modality but is limited to imaging positron emitters. Recently, with 89 Zr, which a half-life of 3 days, attracted much attention in immuno-PET visualize immune cells and cancer by targeting specific antibodies on the cell surface. However, Zr emits single gamma ray at 909 keV four times more frequently than positrons, causing image quality degradation conventional PET. To overcome this drawback, use such rays for was previously proposed as whole...
ABSTRACT Blunt abdominal trauma causing intraperitoneal injury and/or bleeding can be life‐threatening, requiring immediate intervention. Diagnosing these cases challenging, especially when pre‐existing conditions are involved. Low‐grade appendiceal mucinous neoplasm (LAMN) is a rare tumor of the appendix that lead to pseudomyxoma peritonei. Herein, we present case ruptured LAMN following blunt after high‐energy head‐on collision, complicating differentiation from other injuries. A...
Radiometal-labeled peptide-based radiopharmaceuticals (RLPB-radiopharmaceuticals) are promising for cancer imaging and targeted radiotherapy; however, their effectiveness is often compromised by the high retention of nonspecific radioactivity in kidneys due to renal excretion pathways. Current strategies address this issue have limitations, highlighting need innovative approaches improve targeting specificity therapeutic efficacy. We aimed evaluate applicability Gly-Phe-Lys (GFK) tripeptide,...
<title>Abstract</title> <bold>Purpose</bold>: To conduct the first-in-human evaluation of novel PET tracer [3-<sup>11</sup>C]AIB, which primarily targets System A amino acid transport, by assessing its biodistribution, radiation dosimetry, and safety in healthy volunteers. <bold>Methods</bold>: Six male participants underwent whole-body PET/CT scans following a rapid intravenous bolus [3-<sup>11</sup>C]AIB (injected dose: 366.9 ± 17.9 MBq). Dynamic imaging upper abdomen was performed for 4...