A5029543712- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Ionosphere and magnetosphere dynamics
- Solar and Space Plasma Dynamics
- Planetary Science and Exploration
- Earthquake Detection and Analysis
- Geomagnetism and Paleomagnetism Studies
- Space Exploration and Technology
- Astro and Planetary Science
- Chemical Reactions and Isotopes
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Lung Cancer Treatments and Mutations
- Hematopoietic Stem Cell Transplantation
- Medical Imaging and Pathology Studies
- Epigenetics and DNA Methylation
- Nuclear Physics and Applications
- Acute Myeloid Leukemia Research
- Boron and Carbon Nanomaterials Research
- Fullerene Chemistry and Applications
- Atomic and Molecular Physics
- Geophysics and Gravity Measurements
- Space exploration and regulation
- Neuroendocrine Tumor Research Advances
- Radiation Detection and Scintillator Technologies
National Institutes for Quantum Science and Technology
2018-2025
University of Tsukuba
2002-2024
Ebina General Hospital
2014-2023
Takasaki Advanced Radiation Research Institute
2018-2022
Japan Atomic Energy Agency
2005-2020
Takasaki City University of Economics
2018
Advanced Science Research Center
2018
Japan Aerospace Exploration Agency
2014
Communications Technology Laboratory
2014
University of Washington
2013
Therapeutic options for patients with malignant pheochromocytoma are currently limited, and therefore new treatment approaches being sought. Targeted radionuclide therapy provides tumor-specific systemic treatments. The β-emitting radiopharmaceutical meta-131I-iodo-benzylguanidine (131I-MIBG) limited survival benefits has adverse effects. A generation of radionuclides using α-particles including meta-211At-astato-benzylguanidine (211At-MABG) expected to have strong therapeutic effects...
The high in vivo stability of 2,2-dihydroxymethyl-3-[18F]fluoropropyl-2-nitroimidazole ([18F]DiFA) prompted us to evaluate neopentyl as a scaffold prepare radiotheranostic system with radioiodine and astatine. Three DiFA analogues one, two, or without hydroxyl group were synthesized. While all 125I-labeled compounds remained stable against nucleophilic substitution, only glycol was cytochrome P450 (CYP)-mediated metabolism showed deiodination. 211At-labeled also both substitution...
Abstract Purpose Patients who develop metastatic melanoma have a very poor prognosis, and new treatments are needed to improve the response rates. Melanocortin-1 receptor (MC1R) is promising target for radionuclide therapy of melanoma, alpha-melanocyte stimulating hormone (α-MSH) peptide analogs show high affinities MC1Rs. Because targeted alpha (TAT) can be desirable treatment this study aimed an 211 At-labeled α-MSH analog TAT melanoma. Methods We designed labeled with At using neopentyl...
A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The involves five steps: (1) dissolution in conc. HNO3; (2) removal the HNO3 by distillation; (3) residue 8 M HCl; (4) extraction HCl into DIPE; and (5) DIPE NaOH. Results 55 “optimized” runs gave recovery yields approximately 78% after decay attenuation corrections. An attenuation-corrected average 26 ± 3 mCi provided isolated (actual) 16 211At. sixth step, used purification trace metals, was...
Non‐small cell lung carcinomas (NSCLC) overexpress the Her2/neu gene in approximately 59% of cases. Trastuzumab, a humanized monoclonal antibody, interferes with Her2 signaling and is approved for treatment overexpressing breast cancer. However, its therapeutic use NSCLC remains obscure. The present study aimed to determine role 64 Cu‐labeled trastuzumab positron emission tomography (PET) non‐invasive imaging expression NSCLC. Trastuzumab was conjugated bifunctional chelator 1, 4, 7,...
Purpose To develop a silicon (Si) and cadmium telluride (CdTe) imaging Compton camera for biomedical application on the basis of technologies used astrophysical observation to test its capacity perform three-dimensional (3D) imaging. Materials Methods All animal experiments were performed according Animal Care Experimentation Committee (Gunma University, Maebashi, Japan). Flourine 18 fluorodeoxyglucose (FDG), iodine 131 (131I) methylnorcholestenol, gallium 67 (67Ga) citrate, separately...
Electrophilic desilylation allows for convenient and reproducible synthesis of the aromatic amino acid derivative 4-[<sup>211</sup>At]astato-<sc>l</sc>-phenylalanine.
Whistler observations at Okinawa (geomagnetic latitude 15.3°N), Japan, have been carried out as one of the IMS projects since October 1974. Whistlers and their echoes following Eckersley's law observed mainly during winter night. The diurnal variation whistler occurrence has no evening peak, while that mid‐latitudes an evident peak. This may be due to D region absorption resulting from late sunset in subtropical region, a lack field‐aligned ducts, by ion‐electron Coulomb collision...
Radiolabeled amino acids are superior PET tracers for the imaging of malignant tumors, and labeled with <sup>76</sup>Br, an attractive positron emitter because its relatively long half-life (16.2 h), could potentially be a widely usable tumor tracer. In this study, in consideration stability specificity, we designed two <sup>76</sup>Br-labeled acid derivatives, 2-<sup>76</sup>Br-bromo-α-methyl-l-phenylalanine (2-<sup>76</sup>Br-BAMP) 4-<sup>76</sup>Br-bromo-α-methyl-l-phenylalanine...
(1) Background: Deferoxamine B (DFO) is the most widely used chelator for labeling of zirconium-89 (89Zr) to monoclonal antibody (mAb). Despite remarkable developments clinical 89Zr-immuno-PET, chemical species and stability constants Zr-DFO complexes remain controversial. The aim this study was re-evaluate their by identifying demonstrate that can estimate radiochemical yield (RCY) chelator-to-antibody ratio (CAR). (2) Methods: were determined UV ESI-MS spectroscopy. Stability speciation...
<i>Meta</i>-iodobenzylguanidine (MIBG) labeled with <sup>123</sup>I or <sup>131</sup>I has been widely used for the diagnosis and radiotherapy of norepinephrine transporter (NET)–expressing tumors. However, <sup>123</sup>I/<sup>131</sup>I-MIBG limitations detecting small lesions because its lower spatial resolution than PET tracers. In this study, <i>meta</i>-bromobenzylguanidine (MBBG) <sup>76</sup>Br (half-life, 16.1 h), an attractive positron emitter, was prepared evaluated as a potential...
The Low Frequency plasma wave Analyzer, LFA, on board the PLANET-B spacecraft has been developed to measure Martian waves. Two orthogonal electric dipole wire antennas, 50 m tip-to-tip, in spin plane are used waves, dc fields, and potential relative ambient plasma. LFA capability spectrum band from 10 Hz 32 kHz, capture signal waveform kHz by using a 4 MByte memory. scientific objectives explore following: (1) Macroscopic environment boundaries solar wind ionosphere, (2) Microscopic...