A5038090853- Radiopharmaceutical Chemistry and Applications
- Photonic and Optical Devices
- Semiconductor Lasers and Optical Devices
- Pharmacological Receptor Mechanisms and Effects
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Optical Network Technologies
- Medical Imaging Techniques and Applications
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Advanced Photonic Communication Systems
- Lung Cancer Treatments and Mutations
- Semiconductor Quantum Structures and Devices
- Chemical Synthesis and Analysis
- Bone health and treatments
- Radioactive contamination and transfer
- Chemical Reactions and Isotopes
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Ion channel regulation and function
- Medical Imaging and Pathology Studies
- Cardiac Imaging and Diagnostics
- HER2/EGFR in Cancer Research
- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
Kanazawa University
2013-2022
Advanced Science Research Center
2012-2021
Kanazawa University Hospital
2017-2021
Japanese Circulation Society
2019
Toyama Prefectural Agricultural, Forestry & Fisheries Research Center
2018
Niigata University
2018
The University of Tokyo
1999-2017
Tokushima University
2017
Japan Society for the Promotion of Science
2017
Hyogo Medical University
2009-2011
Background Pancreatic ductular adenocarcinoma (PDAC) is among the most dreadful of malignancies, in part due to lack efficacious chemotherapy. Immune checkpoint inhibitors, including anti-programmed cell death 1 (anti-PD-1) antibodies, are novel promising forms systemic immunotherapy. In current study, we assessed whether gemcitabine (GEM) combined with anti-PD-1 antibody treatment was as immunochemotherapy for advanced PDAC using a murine model liver metastasis. Methods The metastasis...
CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes hematopoietic or intestinal stem cells. Although CD157/Bst1 risk locus in Parkinson's disease (PD), little about CD157 nervous system contribution to PD progression. Here, we show no apparent motor dysfunction was observed young knockout (CD157 (-/-)) male mice under less aging-related effects on behaviors. (-/-) exhibited...
Alpha particle-emitting radionuclides have gained considerable attention for radionuclide therapy. Astatine-211 (211At) is a promising alpha radionuclide. 211At halogen that has similar chemical properties to iodine and exhibits half-life of 7.2 h. However, direct labeling proteins or peptides into the tyrosine residue with was shown be impractical. Herein, we demonstrate novel 211At-labeling method using RGD peptide as model peptide. An 211At-labeled peptide, [211At]c[RGDf(4-At)K], prepared...
Osimertinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor approved for treating non-small-cell lung cancer (NSCLC) with EGFR mutations. Genetic testing required to detect the mutation selecting patients who can use osimertinib. Here, we report attempt develop nuclear imaging probes that We designed and synthesized I-osimertinib Br-osimertinib a radioactive or nonradioactive halogen atom at indole ring in osimertinib evaluated them.
68Ga (T1/2 = 68 min, a generator-produced nuclide) has great potential as radionuclide for clinical positron emission tomography (PET). Because poly-glutamic and poly-aspartic acids have high affinity hydroxyapatite, to develop new bone targeting 68Ga-labeled imaging agents PET, we used 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelating site conjugated aspartic peptides of varying lengths. Subsequently, compared Ga complexes, Ga-DOTA-(Asp)n (n 2, 5, 8, 11, or 14) with...
Probes for radiotheranostics could be produced by introducing radionuclides with similar chemical characteristics into the same precursors. We recently developed an 211At-labeled RGD peptide and a corresponding radioiodine-labeled peptide. Both labeled peptides accumulated in large quantities tumor biodistribution, demonstrating their usefulness radiotheranostics. In this study, we hypothesized that probes combined multiradionuclides, such as 68Ga 211At, have useful clinical applications....
Tenascin-C, an extracellular matrix glycoprotein, appears only in the early stages of embryonic development. It is not normally expressed adult heart but does reappear transiently distinct areas association with active tissue remodeling. The aim this study was to explore serial changes expression tenascin-C after myocardial ischemia and reperfusion, using <sup>125</sup>I-labeled anti–tenascin-C antibody (<sup>125</sup>I-TNC-Ab) a rat model acute reperfusion. <b>Methods:</b> left coronary...
67Ga-DOTA-(L-Asp)11 and 67Ga-DOTA-(L-Asp)14, which have been developed as bone imaging agents, showed a high accumulation in rapid blood clearance mice. However, peptides composed of D-amino acids are more stable vivo than those their L-equivalents. In this study, 67Ga-DOTA-(D-Asp)n (n = 2, 5, 8, 11, or 14) were synthesized using the Fmoc-based solid-phase methodology evaluated. hydroxyapatite binding assay, tended to increase with increasing length amino acid chain. 67Ga-DOTA-(D-Asp)11...
Radiolabeled cyclic peptides containing the (Arg-Gly-Asp) RGD sequence for use in positron emission tomography (PET) imaging, single-photon computed (SPECT) and targeted radionuclide therapy of cancer have been reported. In this study, was used as a model carrier peptide diagnosis cancer. To evaluate characteristics radiohalogen-labeled peptides, several kinds labeled [125I-c(RGDyK), 77Br-c(RGDyK), [125I]SIB-c(RGDfK), [77Br]SBrB-c(RGDfK), [125I]SIB-EG2-c(RGDfK), [77Br]SBrB-EG2-c(RGDfK)] were...
Background Release of radionuclides, such as 137Cs and 90Sr, into the atmosphere ocean presents an important problem because internal exposure to 90Sr could be very harmful humans. Chlorella has been reported effective in enhancing excretion heavy metals; thus, we hypothesized that also enhance elimination or from body. We evaluated potential a decorporation agent vitro vivo, using 85Sr instead 90Sr. Methods In experiments adsorption were performed under wide pH conditions. The maximum...
It has been reported that sigma receptors are highly expressed in a variety of human tumors. In this study, we selected (+)-2-[4-(4-iodophenyl)piperidino] cyclohexanol [(+)-pIV] as receptor ligand and evaluated the potential radioiodinated (+)-pIV for tumor imaging therapy. (+)-[(125/131)I]pIV was prepared by an iododestannylation reaction under no-carrier-added conditions with radiochemical purity over 99% after HPLC purification. Biodistribution experiments were performed intravenous...
A relationship between l-[methyl-(11)C]methionine ((11)C-methionine) uptake and angiogenesis has been suggested in gliomas. However, methionine myocardial ischemia reperfusion received little attention. We investigated the serial changes mechanisms of (14)C-methionine a rat model reperfusion.The left coronary artery was occluded for 30 min, followed by 1-28 d. At time study, (0.74 MBq) (201)Tl (14.8 were injected intravenously at 20 10 min before sacrifice, respectively. One minute...
Rociletinib (CO-1686), a 2,4-diaminopyrimidine derivative, is highly potent tyrosine kinase inhibitor (TKI) that acts on epidermal growth factor receptor (EGFR) with L858R/T790M mutations. We supposed radioiodinated CO-1686 would function as useful tool for monitoring EGFR To aid in patient selection before therapy EGFR-TKIs, this study aimed to develop 125I-labeled derivative of CO-1686, N-{3-[(2-{[4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl]amino}-5-(trifluoromethyl)pyrimidine-4-yl]...
We report the formation of GaAs quantum wires using giant step structure formed during molecular beam epitaxial growth AlGaAs on vicinal (110) surfaces. Atomic force microscope observation indicates that steps extend to over several µm and are coherently aligned. The an AlGaAs/GaAs well (QWL) forms (QWRs) along edges. Carrier confinement into QWRs is caused by increase width (well-width modulation) decrease Al composition in barriers (barrier-compositional modulation), which confirmed...
68Ga (T1/2 = 68 min, a generator-produced nuclide) is an interesting radionuclide for clinical positron emission tomography (PET). Recently, it was reported that radiogallium-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated (Asp)n peptide [Ga-DOTA-(Asp)n] has great potential bone metastases imaging. In the current study, compound containing aspartic linker (D11) as carrier to metastases, RGD [c(RGDfK) peptide] primary cancer, and Ga-DOTA stable radiometal...
Waveguide avalanche photodiodes exhibiting both wide bandwidth and high gain product have been developed. An absorption layer includes a p-type quasi-field-formed multiplication consists of InAlAs with low ionisation rate ratio. Optimisation the design yielded superior performance such as 36.5 GHz, band width 170 GHz quantum efficiency 0.75 A/W.