A5059414275- Medical Imaging Techniques and Applications
- Pharmacological Receptor Mechanisms and Effects
- Receptor Mechanisms and Signaling
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
- Amino Acid Enzymes and Metabolism
- Advanced MRI Techniques and Applications
- Neuropeptides and Animal Physiology
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Lanthanide and Transition Metal Complexes
- Dementia and Cognitive Impairment Research
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Chemical Reactions and Isotopes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer Research and Treatments
- Metabolism and Genetic Disorders
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Computational Drug Discovery Methods
Chiba University Hospital
2025
Tokyo Metropolitan Institute of Gerontology
2012-2022
Fukushima Medical University
2016-2022
Southern Tohoku General Hospital
2015-2022
Cyclotron (Netherlands)
1986-2017
Tokyo Metropolitan Komagome Hospital
2015-2016
Toranomon Hospital
2008-2015
University Medical Center Groningen
2001-2014
University of Groningen
1988-2014
University of California, Davis
2012
Object The authors retrospectively analyzed the data obtained in patients who had undergone l-[methyl-11C] methionine (MET)—positron emission tomography (PET) studies to clarify relationship between MET uptake and tumor biological features discuss clinical usefulness of MET-PET studies. Methods One hundred ninety-four with cerebral glioma or suspected underwent PET scanning 20 minutes after injection MET, whose into was expressed as a ratio contralateral healthy brain tissue (T/N ratio)....
Adenosine A2A receptors (A2ARs) are thought to interact negatively with the dopamine D2 receptor (D2R), so selective A2AR antagonists have attracted attention as novel treatments for Parkinson's disease (PD). However, no information about in living patients PD is available. The purpose of this study was investigate relationship between A2ARs and dopaminergic system striata drug-naïve dyskinesia, alteration these after antiparkinsonian therapy. We measured binding ability striatal using...
The objective of this study was to investigate the mapping sigma1 receptors in Parkinson's disease (PD) using [11C]SA4503 and positron emission tomography (PET), assess whether are involved damaged dopaminergic system PD patients.We studied seven normal volunteers six patients. low density dopamine transporters or high were confirmed putamen all patients [11C]CFT [11C]RAC PET. A dynamic series PET data acquisition performed with arterial blood sampling. We computed binding potential (BP)...
Abstract SNCA duplication is a recognized cause of familial Parkinson's disease (PD). We aimed to explore the genetic and clinical variability in manifestation. Molecular characterization was performed using real‐time PCR, SNP arrays, haplotype analysis. further studied those patients who were found harbor with olfactory function tests, polysomnography, PET. identified four new families one sporadic patient duplication. Eleven symptomatic from these presented parkinsonism, which three...
A compartment model has been used for kinetic analysis of dynamic positron emission tomography (PET) data [e.g., 2-deoxy-2-18F-fluoro-D-glucose (FDG)]. The input function the [the plasma time-activity curve (pTAC)] was obtained by serial arterial blood sampling. It is clinical interest to develop a method PET studies that estimates pTAC without needing For this purpose, we propose new extract from brain images using modified independent component [extraction (EPICA). Source codes EPICA are...
A multimodal neuronavigation system using metabolic images with PET and anatomical from MR is described here for glioma surgery. The efficacy of the was evaluated by comparing results that conventional navigation system, which routinely uses CT imaging as guides.Thirty-three patients cerebral underwent 36 operations aid either a or system. All were preliminarily examined l-methyl-[11C] methionine (MET) surgical planning. Seventeen performed integrating MET-PET images. other 19 based solely...
Abstract The purpose of this study was to evaluate the mechanisms age‐related decline dopamine transporter (DAT) and D 2 ‐like receptor (D R) densities in human striatum by focusing on regional difference. Methods: Positron emission tomography (PET) with [ 11 C]CFT C]raclopride for measuring DATs Rs, respectively, performed 16 healthy volunteers ranging from 21 74 years age. To detail difference within striatum, addition conventional region‐of‐interest‐based analysis, we created a parametric...
Cerebral blood flow (CBF) during dynamic exercise has never been examined quantitatively using positron emission tomography (PET). This study investigated changes in CBF that occur over the course of a moderate, steady-state cycling exercise. Global and regional (gCBF rCBF, respectively) were measured oxygen-15-labeled water (H 2 15 O) PET 10 healthy human subjects at rest (Rest), onset (Ex1) later phase (Ex2). At Ex1, gCBF was significantly ( P<0.01) higher (27.9%) than Rest, rCBF Rest...