A5083540706- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Nicotinic Acetylcholine Receptors Study
- Dementia and Cognitive Impairment Research
- Cancer, Hypoxia, and Metabolism
- Pharmacological Receptor Mechanisms and Effects
- Amino Acid Enzymes and Metabolism
- Drug Transport and Resistance Mechanisms
- Lanthanide and Transition Metal Complexes
- Adenosine and Purinergic Signaling
- Lung Cancer Treatments and Mutations
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Peptidase Inhibition and Analysis
- Pharmacological Effects and Toxicity Studies
- Chemical Reactions and Isotopes
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Estrogen and related hormone effects
Tokyo Metropolitan Institute of Gerontology
2015-2024
Cognitive Neuroimaging Lab
2024
Tokyo Metropolitan Geriatric Hospital
2016-2023
Tokyo Institute of Technology
2023
Hamamatsu Photonics (Japan)
2021
Tokyo Metropolitan Komagome Hospital
2017
National Center for Global Health and Medicine
2012
Center for Forensic Mental Health, Chiba University
2009-2011
Chiba University
2009-2010
National Institutes for Quantum Science and Technology
2007
Accumulating evidence suggests that α7 nicotinic receptors (α7 nAChRs), a subtype of nAChRs, play role in the pathophysiology neuropsychiatric diseases, including schizophrenia and Alzheimer's disease (AD). A number psychopharmacological genetic studies shown nAChRs an important deficits P50 auditory evoked potential patients with schizophrenia, (α nAChR agonists would be therapeutic drugs for cognitive impairments associated schizophrenia. Furthermore, some have demonstrated might key...
Cerebral blood flow (CBF) during dynamic exercise has never been examined quantitatively using positron emission tomography (PET). This study investigated changes in CBF that occur over the course of a moderate, steady-state cycling exercise. Global and regional (gCBF rCBF, respectively) were measured oxygen-15-labeled water (H 2 15 O) PET 10 healthy human subjects at rest (Rest), onset (Ex1) later phase (Ex2). At Ex1, gCBF was significantly ( P<0.01) higher (27.9%) than Rest, rCBF Rest...
The acetylcholinesterase (AChE) inhibitor donepezil is also a σ1 receptor agonist. We examined whether binds to receptors in the living human brain after single oral administration. Dynamic positron emission tomography (PET) data acquisition using selective ligand [11C]SA4503 was performed evaluate quantitatively binding of eight healthy male volunteers. Each subject had PET scan before and receiving dose (5 or 10 mg). potential calculated. Doses 5 mg bound with occupancies ∼60% ∼75%,...
The aims of this study were to evaluate the possibility using 11C-methionine (11C-MET) and 11C-4′-thiothymidine (11C-4DST) whole-body PET/CT for imaging amino acid metabolism DNA synthesis, respectively, when searching bone marrow involvement in patients with multiple myeloma (MM) compare these findings those 18F-FDG aspiration cytology. A total 64 MM, solitary plasmacytoma, monoclonal gammopathy undetermined significance, or an unspecified diagnosis prospectively enrolled. All underwent...
A new tracer, 4'-[methyl-(11)C]-thiothymidine ((11)C-4DST), has been developed as an in vivo cell proliferation marker based on the DNA incorporation method. This study evaluated potential of (11)C-4DST PET/CT for imaging non-small lung cancer (NSCLC), compared with (18)F-FDG PET/CT.Eighteen patients lesions were examined by using and (18)F-FDG. We constructed decay-corrected time-activity curves 9 major regions mean standardized uptake value. then maximum value (SUVmax) tumors both Ki-67...
Recently, we developed [methyl-<sup>11</sup>C]4′-thiothymidine (<sup>11</sup>C-4DST) as an in vivo cell proliferation marker. The present study was performed to determine the safety, distribution, radiation dosimetry, and initial brain tumor imaging of <sup>11</sup>C-4DST humans. <b>Methods:</b> Multiorgan biodistribution dosimetry were assessed 3 healthy humans, who underwent 2-h whole-body PET scanning. Radiation estimated from residence times source organs using OLINDA program. Six...
The objective of this study was to investigate the relationship between normalized regional cerebral metabolic rates glucose (normalized-rCMRglc) and gait function in physically mentally high-functioning older women. One hundred eighty-two community-dwelling women (mean age [SD], 69.4 [6.6] years) without disability instrumental activities daily living mobility limitations underwent positron emission tomography with 18F-fluorodeoxyglucose at rest assess brain activity associated function. We...
N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-(11)C-methoxy-N-methylbenzamide ((11)C-ITMM) is a potential radioligand for mapping metabotropic glutamate receptor type 1 (mGluR1) in the brain by PET. The present study was performed to determine safety, distribution, radiation dosimetry, and initial imaging of (11)C-ITMM healthy human subjects.The multiorgan biodistribution dosimetry were assessed 3 subjects, who underwent 2-h whole-body PET scans. Radiation estimated from...
Coffee intake can decrease the risk for Parkinson's disease (PD). Its beneficial effects are allegedly mediated by caffeine through adenosine A2A receptor (A2A R) antagonist action.We aimed to calculate occupancy rates of striatal Rs after coffee in PD.Five patients with PD underwent 11 C-preladenant positron emission tomography scanning at baseline and containing 129.5 mg (n = 3) or 259 2) caffeine. Concurrently, serum levels were measured.The mean level (μg/mL) was 0.374 increased 4.48...
Abstract We present 3 patients as pitfalls of amyloid-beta (Aβ) PET, who underwent 11 C-PiB (Aβ), 18 F-MK-6240 (Alzheimer disease [AD]-tau), and F-THK5351 (astrogliosis) PET examinations. Despite negligible or tiny Aβ pathology, 1 2 were diagnosed with AD the cause symptoms. widespread patient was not However, if we had only conducted might have been AD, whereas AD. Hence, both AD-tau assessments are necessary to relate clinical symptoms pathology.
Abstract Purpose Bayesian penalised likelihood (BPL) reconstruction, which incorporates point-spread-function (PSF) correction, provides higher signal-to-noise ratios and more accurate quantitation than conventional ordered subset expectation maximization (OSEM) reconstruction. However, applying PSF correction to brain PET imaging is controversial due Gibbs artefacts that manifest as unpredicted cortical uptake enhancement. The present study aimed validate whether BPL without would be useful...
Abstract A 26-year-old woman with relapsing-remitting multiple sclerosis (MS) underwent 18 F-THK5351 PET during a remission period. imaging showed that small regions elevated uptake of were scattered in the brain and foci accumulations corresponded anatomically to MS plaques identified by MRI. Because binds monoamine oxidase B highly expressed astrocytes, accumulates lesions undergoing astrogliosis. Hence, present case can represent ongoing astrogliosis inactive (plaques).
The Bayesian penalized likelihood (BPL) reconstruction algorithm, Q.Clear, can achieve a higher signal-to-noise ratio on images and more accurate quantitation than ordered subset-expectation maximization (OSEM). parameter (β) in BPL requires optimization according to the radiopharmaceutical tracer. present study aimed define optimal β value required diagnose Alzheimer disease from brain positron emission tomography (PET) acquired using 18 F-fluoro-2-deoxy-D-glucose ([18 F]FDG) 11 C-labeled...
The alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease. goal this study was to evaluate two carbon-11-labeled nAChR agonists [(11)C]A-582941 [(11)C]A-844606 for their potential novel positron emission tomography (PET) tracers.The tracers were synthesized by methylation corresponding desmethyl precursors using [(11)C]methyl triflate. Effects receptor blockade mice determined...