A5101474481- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Adenosine and Purinergic Signaling
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Lanthanide and Transition Metal Complexes
- Medical Image Segmentation Techniques
- Laser Applications in Dentistry and Medicine
- Cardiovascular and exercise physiology
- Radiation Detection and Scintillator Technologies
- AI in cancer detection
- Neuropeptides and Animal Physiology
- Mast cells and histamine
- Dementia and Cognitive Impairment Research
- Brain Tumor Detection and Classification
- MRI in cancer diagnosis
- Dental Erosion and Treatment
- Functional Brain Connectivity Studies
- Blind Source Separation Techniques
- Neurological disorders and treatments
- Computational Drug Discovery Methods
- Colorectal Cancer Treatments and Studies
Kindai University
2016-2025
Mitsubishi Electric (Japan)
2024
Wakayama Medical University
2023
Tokyo University of Agriculture
2022-2023
Hamamatsu Photonics (Japan)
2019
Hirosaki University
2018
Tokyo Metropolitan Institute of Gerontology
2004-2017
Osaka University Hospital
2011-2014
National Institutes for Quantum Science and Technology
2007-2012
Aichi Gakuin University
2012
The molecular mechanism of the regulation Ca2+ pump ATPase by phospholamban in cardiac sarcoplasmic reticulum was examined using synthetic pep- tides and purified from reticulum.The monomer 52 amino acid residues contains two distinct domains, cytoplasmic (amino acids 1-30) transmembrane 31-52) domains.The peptide corresponding to 1-31 (PLN 1-31) decreased V,,, Ca2+-dependent activity dosedependent manner, while it had no effect on affinity for (KC,).On other hand, 28-47 28-47) increased Kc,...
Adenosine A2A receptors (A2ARs) are thought to interact negatively with the dopamine D2 receptor (D2R), so selective A2AR antagonists have attracted attention as novel treatments for Parkinson's disease (PD). However, no information about in living patients PD is available. The purpose of this study was investigate relationship between A2ARs and dopaminergic system striata drug-naïve dyskinesia, alteration these after antiparkinsonian therapy. We measured binding ability striatal using...
The objective of this study was to investigate the mapping sigma1 receptors in Parkinson's disease (PD) using [11C]SA4503 and positron emission tomography (PET), assess whether are involved damaged dopaminergic system PD patients.We studied seven normal volunteers six patients. low density dopamine transporters or high were confirmed putamen all patients [11C]CFT [11C]RAC PET. A dynamic series PET data acquisition performed with arterial blood sampling. We computed binding potential (BP)...
Root mean square (RMS) of trunk acceleration is seen frequently in gait analysis research. However, many studies have reported that the RMS value was related to walking speed. Therefore, relationship between and speed should be considered when used assess abnormality. We hypothesized values three sensing axes exhibit common proportions for healthy people if they walk at their own preferred abnormal deviate from proportions. In this study, we proposed ratio (RMSR) as a abnormality measure...
A compartment model has been used for kinetic analysis of dynamic positron emission tomography (PET) data [e.g., 2-deoxy-2-18F-fluoro-D-glucose (FDG)]. The input function the [the plasma time-activity curve (pTAC)] was obtained by serial arterial blood sampling. It is clinical interest to develop a method PET studies that estimates pTAC without needing For this purpose, we propose new extract from brain images using modified independent component [extraction (EPICA). Source codes EPICA are...
We propose a method that reconstructs dynamic positron emission tomography (PET) images from given sinograms by using non-negative matrix factorization (NMF) incorporated with deep image prior (DIP) for appropriately constraining the spatial patterns of resultant images. The proposed can reconstruct PET higher signal-to-noise ratio (SNR) and blindly decompose an into pairs temporal factors. former represent homogeneous tissues different kinetic parameters latter time activity curves are...
Abstract Adenosine A 2A receptor (A2AR) is thought to interact with dopamine D 2 receptor. Selective A2AR antagonists have attracted attention as the treatment of Parkinson's disease. In this study, we investigated distribution A2ARs in living human brain using positron emission tomography (PET) and [7‐methyl‐ 11 C]‐( E )‐8‐(3,4,5‐trimethoxystyryl)‐1,3,7‐trimethylxanthine ([ C]TMSX). We recruited five normal male subjects. dynamic series PET scans was performed for 60 min, arterial blood...
The acetylcholinesterase (AChE) inhibitor donepezil is also a σ1 receptor agonist. We examined whether binds to receptors in the living human brain after single oral administration. Dynamic positron emission tomography (PET) data acquisition using selective ligand [11C]SA4503 was performed evaluate quantitatively binding of eight healthy male volunteers. Each subject had PET scan before and receiving dose (5 or 10 mg). potential calculated. Doses 5 mg bound with occupancies ∼60% ∼75%,...
Abstract Background Melanoma is a type of superficial tumor. As advanced melanoma has poor prognosis, early detection and therapy are essential to reduce melanoma‐related deaths. To that end, there need develop quantitative method for diagnosing melanoma. This paper reports the development such diagnostic system using hyperspectral data (HSD) convolutional neural network, which machine learning. Materials Methods HSD were acquired imager, spectrometer can simultaneously capture information...
The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) contribute to epileptogenesis. Thirty patients with epilepsy and 31 healthy controls are scanned using positron emission tomography our recently developed radiotracer for AMPARs, [11C]K-2, which measures the density of cell-surface AMPARs. In focal-onset seizures, an increase in AMPAR trafficking augments amplitude abnormal gamma activity detected by electroencephalography. contrast,...
Through a retrospective analysis of existing FDG PET-MRI images, we recently demonstrated that metformin increases the accumulation in intestinal lumen, suggesting stimulates glucose excretion into intestine. However, details this phenomenon remain unclear. We here investigate detailed dynamics excretion, including rate and metabolism excreted glucose, both presence absence metformin. quantified using newly developed PET-MRI-based bioimaging individuals with type 2 diabetes, treated...
The purpose of this study was to investigate the effect Nd:YAG laser irradiation on acid demineralization enamel and dentin by spectrophotometry. A mechanism acquired resistance is also proposed.The ability enhanced artificial caries formation still controversial.A pulsed at 1.064-micron wavelength used irradiate human samples from 20 extracted molars parameters 1, 2, 3 W pps for a total 9 sec after painting with black ink. Samples were then subjected 2 microliters 0.1 M lactic solution (pH...
Objective: The objective of this study was to evaluate the efficacy Nd:YAG laser remove debris and smear layer on instrumented root canal walls in vitro. Summary Background Data: There have been some contradictory reports about layer. Materials Methods: Thirty-six extracted single mandibular incisor human teeth were used study. sectioned at an enamel–cementum junction roots up # 50-K files size, then divided into three groups 12 teeth. first group (Group 1) unlased as a control, other two...