A5044244200- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Neuroscience and Neural Engineering
- Collagen: Extraction and Characterization
- Periodontal Regeneration and Treatments
- Glaucoma and retinal disorders
- 3D Printing in Biomedical Research
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Photoreceptor and optogenetics research
- Electrospun Nanofibers in Biomedical Applications
- Advanced Drug Delivery Systems
- Silk-based biomaterials and applications
- Bone Tissue Engineering Materials
- Angiogenesis and VEGF in Cancer
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Treatment of Major Depression
- Osteoarthritis Treatment and Mechanisms
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Tissue Engineering and Regenerative Medicine
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
Tohoku University
2016-2025
Keio University Hospital
2025
Keio University
2004-2024
Sapporo Minami Hospital
2022-2024
Tokyo National Hospital
2022
Shimane University
2021
The Centers
2012-2020
Sendai University
2017
Hokkaido University
1995-2014
Institute for Advanced Medical Research
2011-2012
Bone morphogenetic protein (BMP) is known to require a suitable carrier induce ectopic bone formation in vivo. Hydroxyapatite ceramics have been reported be effective some forms but ineffective others as of BMP-induced formation. In this study we compare three geometrically different hydroxyapatite examine their functions carriers A fraction containing all the active BMPs (BMP cocktail) was partially purified from 4M guanidine extract bovine by three-step chromatographic procedure. The BMP...
Enzymatic biofuel cells have attracted much attention for their potential to directly use biochemical energy sources in living organisms such as animals, fruits, etc. However, generally natural a skin, and the oxygen concentration is lower than that of biofuels like sugars. Here, we fabricated novel miniature assembly consists needle bioanode accessing through skins gas-diffusion biocathode utilizing abundant air. The performance was fourfold improved by optimizing its hydrophobicity....
Abstract Angiogenesis plays a critical role in many diseases, including macular degeneration. At present, the pathological mechanisms remain unclear while appropriate models dissecting regulation of angiogenic processes are lacking. We propose an vitro angiogenesis process and test it by examining co-culture human retinal pigmental epithelial cells (ARPE-19) umbilical vein endothelial (HUVEC) inside microfluidic device. From characterisation APRE-19 monoculture, tight junction protein (ZO-1)...
A partially purified BMP preparation was combined with a fibrous glass membrane (FGM) or porous particles of hydroxyapatite (PPHAP), and then implanted subcutaneously into the backs rats. As control these new carriers, conventional carrier insoluble bone matrix (IBM) also used. These geometrically different solid-state carriers induced tissues in quite manners. FGM/BMP implants cartilage formation within entire inner area accompanied by small amount on surface membrane. In contrast, PPHAP/...
The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) contribute to epileptogenesis. Thirty patients with epilepsy and 31 healthy controls are scanned using positron emission tomography our recently developed radiotracer for AMPARs, [11C]K-2, which measures the density of cell-surface AMPARs. In focal-onset seizures, an increase in AMPAR trafficking augments amplitude abnormal gamma activity detected by electroencephalography. contrast,...
Like a carpet for cells, micropatterned polymeric nanosheets are developed toward local cell delivery. The direct morphogenesis of retinal pigment epithelial (RPE) cells and allow the injection an engineered RPE monolayer through syringe needles without loss viability. Such ultrathin carrier has promise minimally invasive delivery into narrow tissue spaces. As service to our authors readers, this journal provides supporting information supplied by authors. materials peer reviewed may be...
Abstract Synaptic phenotypes in living patients with psychiatric disorders are poorly characterized. Excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) is a fundamental component for neurotransmission. We recently developed positron emission tomography (PET) tracer AMPAR, [ 11 C]K-2, the first technology to visualize and quantify AMPARs density human brain. In this study, we characterized major C]K-2. One hundred forty-nine (schizophrenia, n = 42;...
Abstract Background Whereas ketamine's antidepressant effect for treatment-resistant depression (TRD) has been consistent in the literature from North American and European countries (1-3), its evidence is scarce among Asian population (4-6). Aims & Objectives We aimed to evaluate efficacy safety of intravenous ketamine treatment Japanese patients with TRD. Method In this double-blind randomized placebo-controlled trial, 34 (41.4±9.4 years, 23 men [67.6%]) TRD were receive either (0.5...
The retinal pigment epithelium (RPE) performs life-long phagocytosis of lipid-rich photoreceptor outer segments and exchanges energy metabolites with photoreceptors to support function. glucose lipid metabolism are interconnected, but it is unclear how the specialized RPE regulated. We have investigated this unique mechanism. To identify factors involved in regulation we compared screened human epithelial cell line, ARPE-19 under different conditions. Using results these experiments selected...
Abstract Marine‐derived collagen is expected to be a much safer alternative calf collagen, which in medical applications carries the risk of bovine spongiform encephalopathy. In this study, acid‐soluble was extracted from salmon skin and crosslinked with 1‐ethyl‐3‐(3‐dimethylaminopropyl)‐carbodiimide during fibril formation produce (SC) gel. The growth rates differentiated functions human periodontal ligament fibroblasts (HPdLFs) cultured on SC gel were investigated. Growth faster than...
Abstract Elastic salmon collagen (SC) vascular grafts were prepared by incubating a mixture of acidic SC solution and fibrillogenesis‐inducing buffer containing crosslinking agent [water‐soluble carbodiimide (WSC)] in tubular mold at 4°C for 24 h then 60°C 5 min. Subsequently, re‐crosslinking ethanol WSC was performed. The dimension the easily controlled changing size used. compliance (stiffness parameter: β) burst strength (internal diameter, 2 mm; length, 20 wall thickness, 0.75 mm) that...
Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises microfabricated reservoir, controlled-release cover, drug formulations, which are made photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer safer therapeutic method than intravitreal injections for disease treatments. As service to...