A5008391815- Lymphoma Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Systemic Sclerosis and Related Diseases
- Cardiovascular Health and Disease Prevention
- Genetics and Neurodevelopmental Disorders
- Speech Recognition and Synthesis
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Immune Cell Function and Interaction
- Gut microbiota and health
- Cancer Treatment and Pharmacology
- Viral-associated cancers and disorders
- Diagnosis and Treatment of Venous Diseases
- Hernia repair and management
- Blood Pressure and Hypertension Studies
- Respiratory Support and Mechanisms
- Multiple Myeloma Research and Treatments
- Plant and Fungal Interactions Research
- Intraperitoneal and Appendiceal Malignancies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Eosinophilic Disorders and Syndromes
- Speech and dialogue systems
- Microbial Metabolites in Food Biotechnology
- Dermatology and Skin Diseases
- Medical Imaging Techniques and Applications
Kubota (Japan)
2025
Kindai University
2020-2025
Institute of Brain and Blood Vessels
2025
Japanese Red Cross Society Kyoto Daini Hospital
2025
Fukushima Medical University
2017-2024
The University of Tokyo
2015-2024
Kobe University
2023-2024
Futaba (Japan)
2024
Himeji Red Cross Hospital
2023
Hitotsubashi University
2023
Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe neurodevelopmental disorders. Recently we have generated Cdkl5 KO mice by targeting exon 2 on C57BL/6N background, and demonstrated postsynaptic overaccumulation of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors hippocampus. In current study, subjected to a battery comprehensive behavioral tests, aiming reveal effects loss CDKL5 whole perspective motor, emotional, social, cognition/memory functions, identify...
The differences in clinical features between influenza A H1N1, H3N2, and B the past three seasons were examined.Patients with respiratory symptoms who consulted Kurume University Medical Center, Department of Internal Medicine, Kurume, Fukuoka, Japan, from January to March 1999, 2000, 2001 included. Based on virological serological findings, patients divided into above groups for comparison laboratory data.(n = 196) included 54 98 44 B. Mean ages 33 +/- 8.4 years, 41 15.2 29 9.8 years...
ABSTRACT Plants have mutualistic symbiotic relationships with rhizobia and fungi by the common symbiosis pathway, of which Ca 2+ /calmodulin-dependent protein kinase (encoded CCaMK ) is a central component. Although Oryza sativa ( OsCCaMK required for fungal accommodation in rice roots, little known about role bacteria. Here, we report effect Tos17 -induced mutant (NE1115) on CH 4 flux low-nitrogen (LN) standard-nitrogen (SN) paddy fields compared wild-type (WT) Nipponbare. The growth NE1115...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 185:285-291 (1999) - doi:10.3354/meps185285 Predation on naked protozoan microzooplankton by fish larvae Kimio Fukami1,*, Aki Watanabe1, Shinji Fujita2, Kosaku Yamaoka3, Toshitaka Nishijima1 1Laboratory of Aquatic Environmental Science (LAQUES), Kochi University, Nankoku, 783-8502, Japan 2Nishinihon Institute...
Membrane fusion is the first essential step in HIV-1 replication. The gp41 subunit of envelope protein (Env), a class I protein, achieves membrane by forming structure called six-helix bundle composed N- and C-terminal heptad repeats. We have recently shown that distal portion α9 helix repeat X4-tropic HXB2 Env plays critical role late-stage viral infection. Here, we used R5-tropic JRFL constructed six alanine insertion mutants, 641+A to 646+A, further where several glutamine residues are...
[Purpose] This study aimed to determine the effect of varying hip flexion angle on muscle activity during isometric contraction in abduction. [Subjects] Twenty-seven healthy men (mean age=21.5 years, SD=1.2) participated this study. [Methods] Surface electromyography (EMG) was recorded upper portion gluteus maximus (UGM), lower (LGM), tensor fasciae latae (TFL), and medius (GMed) under two measurement conditions: (0, 20, 40, 60, 80 degrees) abduction joint at 80% maximum strength. Integrated...
Hypertension induces cardiovascular hypertrophy and fibrosis. Infiltrated macrophages are critically involved in this process. We recently reported that inhibition of prolyl hydroxylase domain protein 2 (PHD2), which hydroxylates the proline residues hypoxia-inducible factor-α (HIF-α) thereby HIF-α degradation, suppressed inflammatory responses macrophages. examined whether myeloid-specific Phd2 deletion affects hypertension-induced remodeling.Myeloid-specific PHD2-deficient mice (MyPHD2KO)...
Positron emission tomography (PET) with 15O-gas for quantifying cerebral blood flow (CBF) and oxygen metabolism is the gold standard assessing hemodynamics in ischemic cerebrovascular disease. However, conventional PET methods do not provide information on regional arrival timing, a hemodynamic parameter typically measured using computed (CT) perfusion contrast media. This study demonstrated that state-of-the-art clinical scanner optimized analysis can generate time maps. In this...
Endothelial dysfunction and autonomic nervous system imbalance are both risk markers of atherosclerotic vascular damage. The relationship between these 2 factors, however, has not been clarified concisely.Flow-mediated dilation (FMD) was measured in 47 patients with ischemic heart disease (IHD; mean age, 68.1±7.1 years) using an ultrasound semi-automatic measuring (UNEXEF18G), activity evaluated by simultaneous measurements rate variability. FMD significantly correlated standard deviation...
To investigate the clinical significance of flow-mediated dilation (FMD) in systemic sclerosis (SSc).Thirty-three SSc patients and 12 healthy controls were studied. Ultrasound assessment brachial artery FMD was performed on all subjects. The results expressed as percentage increase diameter following hyperemia.Limited cutaneous (lcSSc) had significantly lower values than (5.3 ± 2.7 versus 7.7 2.0 %, p < 0.05), while diffuse (dcSSc) (6.7 4.0 %) comparable to those lcSSc controls. Although did...
In the present study we sought to determine effect of CoCl2, an inhibitor PHD (prolyl hydroxylase domain protein), on development AAA (abdominal aortic aneurysm). was induced in C57BL/6 mice by periaortic application CaCl2 (AAA group). NaCl (0.9%)-treated were used as a sham control (SHAM Mice treated with 0.05% CoCl2 drinking water (AAA/CoCl2 At 1 and 6 weeks after operation, tissue excised for further examination. After treatment, diameter macrophage infiltration into adventitia increased...
Water-soluble dietary fiber is known to modulate fecal microbiota. Although there are a few reports investigating the effects of intake timing on metabolism, none effect Therefore, in this study, we examined inulin-containing food Mice were housed under conditions with two-meals-per-day schedule, long fasting period morning and short evening. Then, 10–14 days after inulin intake, cecal content feces collected, pH short-chain fatty acids (SCFAs) measured. The microbiome was determined using...