A5049987199- Dementia and Cognitive Impairment Research
- Medical Imaging Techniques and Applications
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Biochemical effects in animals
- Stress Responses and Cortisol
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Cerebrovascular and Carotid Artery Diseases
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Radiopharmaceutical Chemistry and Applications
- Advanced X-ray and CT Imaging
- Medicinal Plants and Bioactive Compounds
- Sleep and Wakefulness Research
- Neurological Disorders and Treatments
- Cerebrovascular and genetic disorders
- MRI in cancer diagnosis
San Francisco VA Medical Center
2024
University of California, San Francisco
2024
Tokyo Metropolitan Institute of Gerontology
2022-2023
Saitama Medical University Hospital
2008-2023
National Institutes for Quantum Science and Technology
2022-2023
Tokyo Metropolitan Geriatric Hospital
2013-2022
National Center of Neurology and Psychiatry
2006-2022
Theranostics (New Zealand)
2022
Imaging Center
2016-2022
National Institute for Japanese Language and Linguistics
2022
<h3>BACKGROUND AND PURPOSE:</h3> The necessity for structural MRI is greater than ever to both diagnose AD in its early stage and objectively evaluate progression. We propose a new VBM-based software program automatic detection of specific atrophy AD. <h3>MATERIALS METHODS:</h3> A target VOI was determined by group comparison 30 patients with very mild 40 age-matched healthy controls using SPM. Then this incorporated into newly developed automated independently running on Windows PC VBM SPM8...
The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. 18F-fluorodeoxyglucose tomography voxel-based analysis used compare regional brain utilization 12 nonmedicated patients, without their experiencing attacks during acquisition, that 22 healthy controls. Panic showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of uptake the bilateral amygdala, hippocampus,...
Our goal in this study was to determine whether or not anserine/carnosine supplementation (ACS) is capable of preserving cognitive function elderly people. In a double-blind randomized controlled trial, volunteers were randomly assigned an ACS placebo group at 1:1 ratio. The took 1.0 g (3:1) formula daily for 3 months. Participants evaluated by psychological tests before and after the 3-month period. Thirty-nine healthy (60-78 years old) completed follow-up tests. Among tests, delayed recall...
The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database healthy controls from the common systems available in Japan. This study included 510 sets data 256 (116 men and 140 women; age range, 30–83 years) acquired eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only using Chang method (ChangACNOSC) X-ray CT (CTACNOSC), both (ChangACSC) (CTACSC). These images analyzed Southampton method. outcome measure...
We performed fMRI measurements in normal children to clarify which cortical areas are commonly involved the mirror system (MS) and mentalizing, specific for whether have same neural networks MS mentalizing as adults. Normal had Common activations were found superior temporal sulcus fusiform gyri, whereas activation was medial prefrontal, pole inferior parietal cortices. suggest that might evolve from a capacity detect motion of agents infer intentions. Further, require self-perspectives.
A physical 3-dimensional phantom that simulates PET/SPECT images of static regional cerebral blood flow in grey matter with a realistic head contour has been developed. This study examined the feasibility using this for evaluating images.The was constructed transparent, hydrophobic photo-curable polymer laser-modelling technique. The designed to contain matter, skull, and trachea spaces filled radioactive solution, bone-equivalent solution K(2)HPO(4), air, respectively. bone compartments...
Automated subfield volumetry of hippocampus is desirable for use in temporal lobe epilepsy (TLE), but its utility has not been established. Automatic segmentation hippocampal subfields (ASHS) and the new version FreeSurfer software (ver.6.0) using high-resolution T2-weighted MR imaging are candidates this volumetry. The aim study was to evaluate TLE patients ASHS as well old versions FreeSurfer.We recruited 50 consecutive unilateral including 25 with sclerosis (TLE-HS) without obvious...
Carnosine and anserine are strong antioxidants, previously demonstrated to reduce cognitive decline in animal studies. We aimed investigate their neurophysiological effects, using functional MRI, on humans. Thirty-one healthy participants (age 40-78, 10 male/21 female) were recruited a double-blind placebo-controlled study. Participants assigned twice-daily doses of imidazole dipeptide formula (n = 14), containing 500 mg (carnosine/anserine, ratio 1/3) or an identical placebo 17). Functional...
Our goal was to determine whether anserine/carnosine supplementation (ACS) suppresses chemokine levels in elderly people. In a double-blind randomized controlled trial, volunteers were assigned the ACS or placebo group (1:1). Sixty healthy (active, n = 30; placebo, 30) completed study. The administered 1.0 g of (3:1) for 3 months. A microarray analysis and subsequent quantitative real-time polymerase chain reaction (qRT-PCR) peripheral blood mononuclear cells (PBMCs) showed decreased...
Dementia with Lewy bodies (DLB) is often cited as the second most common dementia after Alzheimer's disease (AD). It clinically important to distinguish DLB from AD because specific side effects of antipsychotic drugs are limited DLB. The relative preservation cingulate glucose metabolism in posterior gyri versus that precuni, known island sign (CIS), patients compared supposed be highly for diagnosing In a previous study, using brain perfusion SPECT, largest value (0.873) area under...
In addition to occipital hypoperfusion, preserved metabolism of the posterior cingulate gyri (PCG) relative precunei is known as island sign (CIS) in patients with dementia Lewy bodies (DLB). CIS has been detected using [(18)F]fluorodeoxyglucose positron emission tomography but not brain perfusion single-photon computed (SPECT). The purpose this study was optimize SPECT enable differentiation DLB from Alzheimer's disease (AD) and hypoperfusion. Eighteen probable 17 age-matched Pittsburgh...
Abstract Repetitive transcranial magnetic stimulation (rTMS) recently has been assessed as a noninvasive treatment modality for movement and psychiatric disorders, whereas the mechanism underlying therapeutic effects is not fully understood. Studies in rodents showed lasting functional changes some selected regions, such limbic‐associated structures, but unfocused brain did clarify regional effects. To address topographical temporal profiles of on glucose metabolism primate brain, we...
Purpose: Respiratory monitoring systems are used to detect the respiratory phase of patients during planning and administration gated radiotherapy by using four‐dimensional computed tomography (4DCT) or 4D positron‐emission tomography/CT (4DPET/CT) linear accelerator (linac), respectively. Generally, identical for 4DCT, 4DPET/CT, linac. However, different sometimes in combination because accessibility may differ manufacturer. The combined use phase‐based gating is concern differences timing...
The purpose of this study was to identify brain atrophy specific for dementia with Lewy bodies (DLB) and evaluate the discriminatory performance between DLB Alzheimer's disease (AD).We retrospectively reviewed 60 30 AD patients who had undergone 3D T1-weighted MRI. We randomly divided into two equal groups (A B). First, we obtained a target volume interest (VOI) DLB-specific using correlation analysis percentage rate significant whole white matter (WM) calculated Voxel-based Specific...
Abstract The voxel‐based morphometry ( VBM ) technique using brain magnetic resonance imaging MRI objectively maps gray matter loss on a voxel‐by‐voxel basis after anatomic standardization. In patients with A lzheimer's disease AD ), reductions of volume, mainly in the medial temporal structures, have been reported; however, inhomogeneity and geometric distortion field intensity hampers reproducibility . present study, we developed novel computed tomography CT )‐based method used this to...