A5024754929- Epilepsy research and treatment
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Pharmacological Effects and Toxicity Studies
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Cerebrovascular and Carotid Artery Diseases
- ECG Monitoring and Analysis
- Peripheral Artery Disease Management
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Growth Hormone and Insulin-like Growth Factors
- Traumatic Brain Injury and Neurovascular Disturbances
- Pregnancy and Medication Impact
- Cardiac Imaging and Diagnostics
- Molecular Biology Techniques and Applications
- Ion channel regulation and function
- Vascular Procedures and Complications
- Birth, Development, and Health
- Acute Myocardial Infarction Research
- Thyroid Disorders and Treatments
- Facial Nerve Paralysis Treatment and Research
- Neurological disorders and treatments
- Ion Channels and Receptors
Academic Rights Press (United Kingdom)
2024
Kyoto Katsura Hospital
2012-2024
Nakamura Memorial Hospital
2011-2023
Kyoto Prefectural University of Medicine
2002-2022
Sapporo Minami Hospital
2021-2022
Memorial Hospital
2022
Kumamoto University
2022
Kyoto University
2022
National Cerebral and Cardiovascular Center
2022
Kobe University
2022
Importance Women with epilepsy (WWE) require treatment antiseizure medications (ASMs) during pregnancy, which may be associated an increased risk of major congenital malformations (MCMs) in their offspring. Objective To investigate the prevalence MCMs after prenatal exposure to 8 commonly used ASM monotherapies and changes MCM over time. Design, Setting, Participants This was a prospective, observational, longitudinal cohort study conducted from June 1999 October 2022. Since 1999, physicians...
Stormorken syndrome is a rare autosomal-dominant disease with mild bleeding tendency, thrombocytopathy, thrombocytopenia, anemia, asplenia, tubular aggregate myopathy, miosis, headache, and ichthyosis. A heterozygous missense mutation in STIM1 exon 7 (c.910C>T; p.Arg304Trp) (NM_003156.3) was found to segregate the six patients four families. Upon sensing Ca2+ depletion endoplasmic reticulum lumen, undergoes conformational change enabling it interact open ORAI1, release-activated channel...
<h3>Objective</h3> Changes in prescribing patterns of antiepileptic drugs (AEDs) pregnant women with epilepsy would be expected to affect the risk major congenital malformations (MCMs). To test this hypothesis, we analyzed data from an international pregnancy registry (EURAP). <h3>Methods</h3> EURAP is observational prospective cohort study designed determine MCMs after prenatal exposure AEDs. The Cochrane-Armitage linear trend analysis was used assess changes AED treatment, prevalence MCMs,...
To investigate the association between regional brain oxygen saturation (rSO2) at hospital arrival and neurological outcomes 90 days in patients with out-of-hospital cardiac arrest (OHCA).The Japan-Prediction of Outcomes post (J-POP) registry is a prospective, multicenter, cohort study to test whether rSO2 predicts after OHCA. We measured OHCA immediately using near-infrared spectrometer placed on forehead non-blinded fashion. The primary endpoint was "neurological outcomes" OHCA.EMS...
Growth hormone (GH)-releasing (GRH) acts on specific receptors in the anterior pituitary to stimulate synthesis and release of GH. Recent reports suggest that GRH is also synthesized extrahypothalamic tissues. To evaluate potential roles GRH, we studied gene expression various rat tissues by reverse transcribed (RT)-polymerase chain reaction (PCR). Total RNA was extracted from twenty-three organs RT-PCR performed with receptor primers. Highly-sensitive RT-PCR-Southern blotting showed mRNA...
Patients with zoster sine herpete and Ramsay Hunt syndrome without pathognomonic vesicles at the initial visit are often misdiagnosed Bell's palsy treated antiviral agents. With PCR, we found that varicella virus genomes were frequently detectable in auricular skin exudate from patients or before appearance of vesicles.
This study investigated the value of regional cerebral oxygen saturation (rSO2) monitoring upon arrival at hospital for predicting post-cardiac arrest intervention outcomes.We enrolled 1195 patients with out-of-hospital cardiac presumed cause from Japan-Prediction Neurological Outcomes in Patients Post-cardiac Arrest Registry. The primary endpoint was a good neurologic outcome (cerebral performance categories 1 or 2 [CPC1/2]) 90 days post-event.A total 68 (6%) had outcomes. We found mean...
Abstract Background and purpose The management of post‐stroke epilepsy (PSE) should ideally include prevention both seizure adverse effects; however, an optimal antiseizure medications (ASM) regimen has yet been established. this study is to assess recurrence, retention, tolerability older‐generation newer‐generation ASM for PSE. Methods This prospective multicenter cohort (PROgnosis Post‐Stroke Epilepsy [PROPOSE] study) was conducted from November 2014 September 2019 at eight hospitals. A...
We assessed several pharmacological effects on electrocardiogram parameters and effective refractory period (ERP) in a patient with short QT syndrome (SQTS). Pharmacological challenge tests revealed that disopyramide selective I(kr) blocker, nifekalant normalized interval, ERP of the atrial ventricular myocardium. This study suggested should be feasible for drug treatment SQTS. Moreover, interval was paradoxically prolonged at higher heart rates induced isoproterenol infusion or an exercise...
AimOur study aimed at filling the fundamental knowledge gap on characteristics of regional brain oxygen saturation (rSO2) levels in out-of-hospital cardiac arrest (OHCA) patients with or without return spontaneous circulation (ROSC) upon arrival hospital for estimating quality cardiopulmonary resuscitation and neurological prognostication these patients.MethodsWe enrolled 1921 OHCA from Japan – Prediction Neurological Outcomes Patients Post-cardiac Arrest Registry measured their rSO2...
<h3>Background and Objectives</h3> The functional outcome mortality of patients with poststroke epilepsy (PSE) have not been assessed in a prospective study. Previous reports suggested that PSE may suffer from prolonged deterioration after seizure. In this study, we prospectively investigated the analyzed effect seizure recurrence on outcomes. <h3>Methods</h3> This is part Prognosis Post-Stroke Epilepsy multicenter, observational cohort where 392 (at least 1 unprovoked more than 7 days onset...
Rotational atherectomy (RA) is effective for reducing calcified plaque volume as part of percutaneous coronary intervention (PCI). Most lesions are then treated by stenting, but we often observe in-stent restenosis (ISR) due to an under-expanded stent associated with severe calcification, a condition that particularly challenging treat. It unknown if drug-coated balloon (DCB) application following RA can be used "stentless" treatment strategy lesions. The aim this study assess the acute and...
Poststroke epilepsy is a major ischaemic/haemorrhagic stroke complication. Seizure recurrence risk estimation and early therapeutic intervention are critical, given the association of poststroke with worse functional outcomes, quality life greater mortality. Several studies have reported factors for seizure recurrence; however, in epilepsy, role EEG predicting seizures remains unclear. This multicentre observational study aimed to clarify whether findings constitute factor patients epilepsy....
Summary: Purpose: Dystonic posturing (DP) is one of the most reliable lateralizing indicators for temporal lobe epilepsy (TLE). We evaluated ictal hyperperfusional areas in patients with DP by using ictal–interictal subtraction single‐photon emission computed tomography (SPECT). Methods: Ninety‐seven were treated surgically intractable TLE, and 39 underwent interictal SPECT studies same isotope. These divided into three groups: group I contralateral side extended to epileptogenic focus, II...
Abstract Background Some clinical trials have verified the efficacy and safety of paclitaxel drug‐coated balloon (DCB) for small vessel coronary artery disease. However, nonsmall calcified lesions received less attention. Aims This study aimed to investigate DCB treatment various types lesions, including not only disease but also lesions. In this real‐world practice study, in‐stent restenosis was excluded. Methods consecutively included 934 patients with 1751 nonstented who at a...
Summary: Purpose: We describe a patient with complex partial seizure unidirectional olfactory aura associated ipsilateral unruptured aneurysm. Methods and Results: The felt sweet pleasant smell coming from behind her right side every time before the attack. Cranial magnetic resonance imaging (MRI) three‐dimensional computed tomography (CT) angiography revealed large aneurysm at bifurcation of middle cerebral artery compression orbitofrontal cortex. Small spikes were recorded superior...
Although previous studies have indicated that changes in the plasma glucose concentration alter GH secretion rat, roles of hypothalamic GH-releasing hormone (GRH) and somatostatin (SS) modulation not yet been elucidated. We investigated acute effects hypo- hyperglycemia on GRH SS mRNA rat. Long term atrial catheters were implanted male rats, sequential blood sampling was performed conscious animals. Insulin 50% administered iv to induce hyperglycemia, respectively. At end experiment,...
To identify mutations in vacuolar protein sorting 13A (VPS13A) for Japanese patients with suspected chorea-acanthocytosis (ChAc).We performed a comprehensive mutation screen, including sequencing and copy number variation (CNV) analysis of the VPS13A gene, chorein Western blotting erythrocyte ghosts. As results analysis, 17 were molecularly diagnosed ChAc. In addition, we investigated distribution gene clinical symptoms total 39 ChAc, 22 previously reported cases.We identified 11 novel...
A 77‐year‐old man was admitted with an acute coronary syndrome (ACS), severe heart failure (HF), and repeated ventricular fibrillation (VF) episodes. single premature complex (PVC) induced tachycardia (VT), which degenerated to VF reproducibly. This PVC eliminated by catheter ablation at the left posteroseptal region where double Purkinje potentials preceding wave had been recorded. The electrical storm disappeared, programmable stimulation failed induce any tachyarrhythmias after ablation....