A5024179474- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Education, Healthcare and Sociology Research
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Pregnancy and Medication Impact
- Psychosomatic Disorders and Their Treatments
- European and International Law Studies
- Genomics and Rare Diseases
- Neonatal and fetal brain pathology
- Ion channel regulation and function
- Glycogen Storage Diseases and Myoclonus
- Hemoglobinopathies and Related Disorders
- Mental Health and Psychiatry
- Genetics and Neurodevelopmental Disorders
- Pharmaceutical studies and practices
- Schizophrenia research and treatment
- Drug Transport and Resistance Mechanisms
- Bone and Joint Diseases
- Vagus Nerve Stimulation Research
- Autoimmune Neurological Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- Healthcare Systems and Challenges
- Mitochondrial Function and Pathology
Oslo University Hospital
2015-2024
Roche (Switzerland)
2024
Roche (Norway)
2024
Vera Institute of Justice
2024
Sandvik (Norway)
2003-2021
Nevro (United States)
2012-2020
Hudklinikken
2020
Smerteklinikken
2006-2018
St Olav's University Hospital
2011-2017
Norwegian Medical Association
2017
Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is the first, and to date only, idiopathic for which a specific mutation has been found. A missense in critical M2 domain of a4 subunit neuronal nicotinic acetylcholine receptor (CHRNA4) recently identified one large Australian pedigree. Here we describe novel CHRNA4 gene Norwegian family. Three nucleotides (GCT) were inserted at nucleotide position 776 into coding region C-terminal end domain. Physiological investigations...
Summary: Twenty‐one adult in‐patients (11 women, 10 men, aged 18–39 years) with uncontrolled epilepsy participated in a 4‐week intensive physical training program, exercising for at least 45 min three times day, 6 days week, an intensity of minimum 60% maximum oxygen uptake (maximum VO 2 ). The program induced considerable increase (mean 19%). Beneficial psychological and social effects were also recorded. average seizure frequency during the exercise period was compared preexercise...
<h3>Objective</h3> Changes in prescribing patterns of antiepileptic drugs (AEDs) pregnant women with epilepsy would be expected to affect the risk major congenital malformations (MCMs). To test this hypothesis, we analyzed data from an international pregnancy registry (EURAP). <h3>Methods</h3> EURAP is observational prospective cohort study designed determine MCMs after prenatal exposure AEDs. The Cochrane-Armitage linear trend analysis was used assess changes AED treatment, prevalence MCMs,...
Summary : Purpose To compare the exercise habits in a sample of adult outpatients with epilepsy those general population same age and sex furthermore to study physical as seizure precipitant risk sustaining seizure‐related injuries while exercising. Methods Two hundred four active responded two questionnaires. The first one, addressing habits, was selected part broad self‐assessing screening used every second year by marketing media research institute reveal changes average Norwegian's...
Summary: Fifteen women with pharmacologically intractable epilepsy were given physical exercise (aerobic dancing strength training and stretching) for 60 min, twice weekly, 15 weeks. Seizure frequency was recorded by the patients 3–7 months before intervention, during intervention period, 3 after intervention. Medication other known seizure‐influencing factors kept as constant possible. Self‐reported seizure significantly reduced period. The also led to level‐of subjective health complaints,...
Epilepsy represents a substantial personal and social burden worldwide. When addressing the multifaceted issues of epilepsy care, updated epidemiologic studies using recent guidelines are essential. The aim this study was to find prevalence causes in representative Norwegian county, implementing new terminology suggested by International League Against (ILAE).Included were all patients from Buskerud County Norway with diagnosis at Drammen Hospital National Center for Oslo University...
Summary Objective Ketogenic diets reduce seizures in children with drug‐resistant epilepsy. Whether adults benefit from similar treatment has not been clarified. We therefore examined the efficacy of modified Atkins diet focal Methods performed a randomized clinical trial ( RCT ) patients >16 years who had at least 3 per month despite having tried antiepileptic drugs. They were to either 12 weeks on (diet group) or habitual (control group). Primary endpoint was change seizure frequency...
Summary: By means of a questionnaire, we analyzed leisure time habits 44 adult in‐patients with active epilepsy (i.e., at least one seizure month for the last year). Twelve patients had generalized and 32 partial epilepsy. All received antiepileptic drugs (AEDs), none additional handicaps. Despite good facilities in their surroundings participation social, cultural, physical activities, most lived sedentary life. Social contact was limited, they were only half as physically average Norwegian...
The aim of this study was to characterize patients diagnosed with glucose transporter protein-1 deficiency syndrome (GLUT-1 DS) clinically and genetically, evaluate the effect treatment classic ketogenic or modified Atkins diet.We retrospectively studied medical records 10 GLUT-1 DS. Four females six males a median age 15 years were included.The illustrates genetic clinical heterogeneity Analysis SLC2A1 gene disclosed variety mutation types. time between onset symptoms diagnosis more than 11...
Summary: A prospective study on seizure‐related inju ries in Norway's two nursing homes for persons with ep ilepsy was conducted. Sixty‐two multihandicapped pa tients mostly difficult‐to‐treat epilepsy were as sessed 13 months: 6,889 seizures, 2,696 ensuing falls, resulted 80 injuries. The injury risk 1.2%. most frequent injuries mild soft tissue and without cuts. Six serious recorded: leg fractures, one mandibular fracture, neck of the femur skull subdural hematoma. 71‐year‐old woman...
Summary: Purpose: To determine if, and how, epileptiform EEG discharges in children were influenced by physical exercise. Methods: Twenty‐six with intractable partial generalized epilepsy exercised during video‐telemetry recording, aiming at exhaustion after ∼10 min. Results: During the exercise, decreased 20 of 26 (17 had least 25% reduction) showed a rebound increase exercise children) compared to baseline conditions. This exercise‐induced reduction reached statistical significance only 16...
Summary: Purpose: Benign rolandic epilepsy (BRE) is considered a genetically determined idiopathic partial epilepsy. We analyzed large sample of twins from four international twin registers to probe the genetics BRE. also aim synthesize apparently conflicting family and data into model BRE etiology. Methods: Large population‐based registries epilepsies Odense (Denmark), Richmond, Virginia (United States), Oslo (Norway) were reviewed for cases added our Australian data. Diagnosis classic was...
Nakken KO, Lossius MI. Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizure status epilepticus. Acta Neurol Scand: 2011: 124: 99–103.© 2011 John Wiley & Sons A/S. Objectives – To compare the efficacy and tolerability buccal as emergency in adults convulsive non-convulsive seizures epilepticus (SE), ascertain preference between two options among nursing staff. Materials methods The staff our epilepsy centre treated 80 episodes SE lasting more...
Abstract Objective The aim was to examine the influence of modified Atkins diet on serum concentration antiepileptic drugs (AEDs). Methods Prospective data from 63 adult patients with either focal or generalized drug‐resistant epilepsy recruited 12‐week dietary treatment as add‐on AEDs are analyzed. AED concentrations, ketones, glucose, and hemoglobin A1c were measured before after intervention. Paired t test used Spearman correlation coefficient, r , estimated. Results Mean age 37 years...