A5053229121- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Pregnancy and Medication Impact
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Vagus Nerve Stimulation Research
- Hemoglobinopathies and Related Disorders
- Neural dynamics and brain function
- Pregnancy and preeclampsia studies
- Drug Transport and Resistance Mechanisms
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Down syndrome and intellectual disability research
- Advanced MRI Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Genomics and Rare Diseases
- Pharmaceutical studies and practices
- Atomic and Subatomic Physics Research
- Metabolism and Genetic Disorders
- Pharmacovigilance and Adverse Drug Reactions
- Frailty in Older Adults
- Electrolyte and hormonal disorders
- Mental Health and Psychiatry
Rigshospitalet
2015-2024
Copenhagen University Hospital
2013-2024
Academic Rights Press (United Kingdom)
2024
Smerteklinikken
2005-2022
University of Copenhagen
1998-2021
Epilepsy Action
2019-2021
University Medical Center Utrecht
2015-2019
Karolinska Institutet
2006-2019
Sree Chitra Thirunal Institute for Medical Sciences and Technology
2015-2019
University of Pavia
2015-2019
Summary Purpose To analyze seizure control, dose adjustments, and other changes of antiepileptic drug ( AED ) treatment during pregnancy in a large cohort women with epilepsy entering on monotherapy carbamazepine, lamotrigine, phenobarbital, or valproate. Methods Seizure control were recorded prospectively 3,806 pregnancies 3,451 taking part European International Registry Antiepileptic Drugs Pregnancy (EURAP), an international registry. Key Findings Of all cases, 66.6% remained seizure‐free...
Importance Women with epilepsy (WWE) require treatment antiseizure medications (ASMs) during pregnancy, which may be associated an increased risk of major congenital malformations (MCMs) in their offspring. Objective To investigate the prevalence MCMs after prenatal exposure to 8 commonly used ASM monotherapies and changes MCM over time. Design, Setting, Participants This was a prospective, observational, longitudinal cohort study conducted from June 1999 October 2022. Since 1999, physicians...
The mean steady-state plasma concentration of lamotrigine (LTG) was 13 micro mol/L in 22 women taking LTG combination oral contraceptives (OC) compared with 28 among 30 on who did not take OC (p < 0.0001). dose/body weight/plasma 2.1 L/kg/day 0.8 without 0.0001), indicating that levels are reduced by >50% during co-medication. It is advisable to monitor conjunction initiation or withdrawal therapy.
Efficacy and tolerability of the new antiepileptic drug oxcarbazepine, was evaluated in a retrospective multicentre study. The records all 947 epilepsy patients treated with oxcarbazepine eight participating centres from 1981 through 1990 were examined. median daily dose 30 mg/kg children, 18 adults, 15 elderly patients, given b.i.d. or t.i.d. mean plasma levels main active metabolite 88, 79, 68 mumol/l elderly, respectively. In shifted to treatment, seizure frequency unchanged 51-66%,...
Summary: Purpose: This study evaluates the effect of oral contraceptives on lamotrigine (LTG) plasma concentrations and urine excretion LTG metabolites in a double‐blind, placebo‐controlled, crossover patients with epilepsy. Methods: Women epilepsy, treated monotherapy taking combination‐type contraceptives, were randomized to treatment placebo or standard contraceptive pill. The dose‐corrected trough concentration ratio N ‐2‐glucuronide/unchanged after 21 days concomitant was analyzed...
<h3>Objective:</h3> To assess the risk of major congenital malformations (MCMs) in association with maternal use valproic acid (VPA) monotherapy or adjunctive therapy, and its relationship dose. <h3>Methods:</h3> The analysis was based on prospectively acquired data from EURAP, a registry enrolling women treated antiepileptic drugs (AEDs) early pregnancy, which primary outcome is presence MCMs at 1 year after birth. Exposure defined as type dose AEDs time conception. A comparison made among...
Patients with epilepsy are at increased risk of premature death from all causes and likely also sudden unexplained (SUD). Many patients have significant comorbidity, it is unclear how much the can be explained by itself. We aimed to chart incidence unexpected in (SUDEP) estimate SUD conferred independently.We conducted a historical cohort study using data Danish registries complete manual review certificates. The population studied consisted residents age group 1-35 years, period 2000-2006...
To compare the risk of spontaneous abortions and stillbirth associated with maternal use different antiepileptic drugs (AEDs).The EURAP registry is an observational international cohort study primarily designed to determine major congenital malformations (MCMs) after prenatal AED exposure. Using data, we prospectively monitored pregnancies exposed 6 most common monotherapies polytherapy. Intrauterine death (spontaneous abortion combined) was primary endpoint.Of 7,055 monotherapy lamotrigine...
<h3>Objective</h3> Changes in prescribing patterns of antiepileptic drugs (AEDs) pregnant women with epilepsy would be expected to affect the risk major congenital malformations (MCMs). To test this hypothesis, we analyzed data from an international pregnancy registry (EURAP). <h3>Methods</h3> EURAP is observational prospective cohort study designed determine MCMs after prenatal exposure AEDs. The Cochrane-Armitage linear trend analysis was used assess changes AED treatment, prevalence MCMs,...
To study the risk of teratogenicity in infants women with epilepsy.Prospective data from 1996 to 2000 comprised 147 pregnancies. The most frequent antiepileptic drugs (AEDs) used were lamotrigine (LTG) 35% (n = 51), oxcarbazepine (OXC) 25% 37) and valproate (VPA) 20% 30). Seventy-four per cent 109) received monotherapy. Folic acid supplementation was taken during first trimester by 118 patients (80%).The overall malformations among newborns AED-exposed group 3.1% 4). Two children born...
Based on data from the EURAP observational International registry of antiepileptic drugs (AEDs) and pregnancy, we assessed changes in seizure control subsequent AED women who underwent attempts to withdraw valproic acid (VPA) during first trimester pregnancy. Applying Bayesian statistics, compared pregnancies where VPA was withdrawn (withdrawal group, n = 93), switched another (switch 38), or maintained (maintained-therapy 1,588) trimester. The probability primarily secondarily generalized...
Summary Objective Mesial temporal lobe epilepsy ( MTLE ) is one of the most common types intractable epilepsies and often associated with hippocampal sclerosis HS ), which characterized by pronounced loss pyramidal neurons. micro RNA s (mi s) have been shown to be dysregulated in neurodegenerative diseases, we hypothesized that mi could involved pathogenesis . Methods expression was quantified specimens from human patients using microarray quantitative real‐time polymerase chain reaction RT...
<h3>Objective</h3> To determine the diagnostic accuracy and clinical utility of electromagnetic source imaging (EMSI) in presurgical evaluation patients with epilepsy. <h3>Methods</h3> We prospectively recorded magnetoencephalography (MEG) simultaneously EEG performed EMSI, comprising electric imaging, magnetic analysis combined MEG-EEG datasets, using 2 different software packages. As reference standard for irritative zone (IZ) seizure onset (SOZ), we used intracranial recordings...
Ceramides are precursors of complex sphingolipids (SLs), which important for normal functioning both the developing and mature brain. Altered SL levels have been associated with many neurodegenerative disorders, including epilepsy, although few direct links identified between genes involved in metabolism epilepsy.We used quantitative real-time PCR, Western blotting, enzymatic assays to determine mRNA, protein, activity ceramide synthase 2 (CERS2) fiibroblasts isolated from parental control...
We assessed the concentration of oxcarbazepine metabolite 10-hydroxycarbazepine (MHD) in nine pregnancies among seven women before, during, and after pregnancy. The mean dose-corrected MHD was decreased during pregnancy (analysis variance, p = 0.0016), being 72% (SD 13%) first trimester, 74% 17%) second 64% 6%) third 108% 18%) vs before