A5055683958- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Diet and metabolism studies
- Atomic and Subatomic Physics Research
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Functional Brain Connectivity Studies
- Mitochondrial Function and Pathology
- Glycogen Storage Diseases and Myoclonus
- Complementary and Alternative Medicine Studies
- Cannabis and Cannabinoid Research
- Genomic variations and chromosomal abnormalities
- GABA and Rice Research
- Genetics and Neurodevelopmental Disorders
- Polyomavirus and related diseases
- Advanced MRI Techniques and Applications
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
Rigshospitalet
2017-2021
Copenhagen University Hospital
2019-2021
Hvidovre Hospital
2019
Epilepsy Action
2019
Aarhus University Hospital
2019
Országos Idegsebészeti Tudományos Intézet
2005-2017
HUN-REN Institute of Experimental Medicine
2007
Hungarian Academy of Sciences
2007
Pázmány Péter Catholic University
2007
National Center for Spinal Disorders
2004-2005
To evaluate the efficacy and safety of perampanel 2, 4, 8 mg/day added to 1-3 concomitant antiepileptic drugs (AEDs) in patients with uncontrolled partial-onset seizures.During this double-blind, placebo-controlled trial, persisting seizures on AEDs were randomized or placebo following a 6-week baseline phase. Perampanel was titrated weekly by 2 maintained at dose achieved for 13 weeks. Primary endpoints median percent change seizure frequency 50% responder rate. Analysis covariance...
Brain electrical activity is largely composed of oscillations at characteristic frequencies. These rhythms are hierarchically organized and thought to perform important pathological physiological functions. The slow wave a fundamental cortical rhythm that emerges in deep non-rapid eye movement sleep. In animals, the modulates delta, theta, spindle, alpha, beta, gamma ripple oscillations, thus orchestrating brain While can enhance epileptic manifestations, it also underlie essential...
Abstract Sleep‐associated memory consolidation is thought to rely on coordinated information transfer between the hippocampus and neocortex brought about during slow wave sleep (SWS) by distinct local field potential oscillations. Specifically, findings in animals have led concept that ripples originating from combine with spindles provide a fine‐tuned temporal frame for persistent of memory‐related neocortex. The present study focused characterizing relationship parahippocampal ripple...
<h3>Objective</h3> To determine the diagnostic accuracy and clinical utility of electromagnetic source imaging (EMSI) in presurgical evaluation patients with epilepsy. <h3>Methods</h3> We prospectively recorded magnetoencephalography (MEG) simultaneously EEG performed EMSI, comprising electric imaging, magnetic analysis combined MEG-EEG datasets, using 2 different software packages. As reference standard for irritative zone (IZ) seizure onset (SOZ), we used intracranial recordings...
Summary The endocannabinoid system plays a central role in retrograde synaptic communication, and controls both glutamatergic γ‐aminobutyric acid (GABA)ergic transmission via type 1 cannabinoid (CB1) receptor. Both sclerotic human hippocampi the chronic phase of pilocarpine‐induced epilepsy mice with sclerosis, CB1‐receptor–positive interneuron somata were preserved dentate gyrus CA1 area, density CB1‐immunostained fibers increased considerably molecular layer. This suggests that, although...
A large proportion of hippocampal afferents and efferents are relayed through the subiculum. It is also thought to be a key structure in generation maintenance epileptic activity; rhythmic interictal-like discharges were recorded previous studies subicular slices excised from temporal lobe epilepsy patients. In order investigate if how subiculum involved vivo, lateral electrical activity under anesthesia 11 drug-resistant patients undergoing lobectomy. Based on laminar field potential...
To examine the effects of age on different aspects temporal lobe seizure semiology.We performed a video analysis 605 archived seizures from 155 consecutive patients (age 10 months to 49 years) selected by freedom after lobectomy. Eighty had hippocampal sclerosis (HS). Beside semiological classification, we assessed dependency several axes semiology: (1) aura, (2) number lateralizing signs, occurrence ictal (3) emotional (4) autonomic symptoms, (5) automatisms, and (6) secondary...
To describe an unusual clinical presentation of a patient with voltage-gated potassium channel Ab- positive, non-paraneoplastic limbic encephalitis.We performed video-EEG monitoring, structural MRI, (18)F-FDG-PET, (1)H-MRS, neuropsychological testing and antibody serology.A 42-year-old male presented in acute phase encephalitis confirmed by antibodies to channels. His pilomotor status was pharmacoresistant antiepileptic drugs, but responded corticosteroid azathioprine treatment. The MRI...
We present two patients with epilepsy who experienced disabling myoclonic jerks during lamotrigine treatment. Both were young males had intractable cryptogenic generalized since childhood. They received a lamotrigine-valproate combination resulting in an excellent improvement; however, after 2–3 years of therapy, both hospitalized because continuous jerks. The dosage was the same before and at onset myoclonus. When severe myoclonus started, higher serum level (16.5 17.7 mg/L, respectively)...
Summary Vagus nerve stimulation (VNS) is a nonpharmacologic therapeutic option for patients with intractable epilepsy. Better clinical outcomes were recorded in nonfocal and Lennox‐Gastaut syndrome (LGS). We conducted 2‐year, open label, prospective study to measure the seizure outcome of 26 VNS patients. The numbers assessed using clinician’s global impression scale (CGI) patient diaries. average reduction was 23% at first year 22% second year. Seizure more pronounced among than focal...
Incidental paradoxical antiepileptic effect of levetiracetam has been described. The aim the present study was to identify epilepsy patients at risk.We performed a retrospective analysis in 207 treated with levetiracetam. This entailed evaluation patient notes and interviews. A defined as an increased seizure frequency or experience more severe seizures including generalized tonic-clonic (GTCS) within 1 month after starting (LEV).Thirty (14%) experienced effect. Eight them (4%) developed de...
We report on three women and a review of the literature absence status epilepticus over age 50 years. Our aim was to characterize male-female ratio in this condition. Out 16 studies 50, including our cases, female dominance found 15. altogether, 104 (71%) females 42 (29%) males. This gender difference is highly significant (p < 0.00001). conclude that predominantly disorder.
Upper extremity automatisms are considered to be an ipsilateral seizure lateralizing sign in temporal lobe epilepsy (TLE). Herein we describe different types of contralateral upper (CUEAs).One hundred ninety-three video-(electroencephalography) EEG recordings 59 patients were reviewed. Other than two who refused surgery, all underwent standardized lobectomy with favorable postoperative outcome. Fifty-seven seizures 21 selected CUEAs. We evaluated their electroclinical characteristics and...