A5045525083- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Metabolism and Genetic Disorders
- Sleep and Wakefulness Research
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- Neonatal and fetal brain pathology
- Autoimmune Neurological Disorders and Treatments
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Photoreceptor and optogenetics research
- Mitochondrial Function and Pathology
- Neural dynamics and brain function
- Child Development and Digital Technology
- Digital Mental Health Interventions
- Cardiac Arrhythmias and Treatments
- Mobile Health and mHealth Applications
- Glioma Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Cellular transport and secretion
- Psychosomatic Disorders and Their Treatments
- Fetal and Pediatric Neurological Disorders
Semmelweis University
2022-2024
National Institute of Mental Health
2023
Hospices Civils de Lyon
2022
Hôpital Femme Mère Enfant
2022
Országos Idegsebészeti Tudományos Intézet
2012-2021
University of Pecs
2020
New York University
2018
Columbia University
2018
Colby College
2011
HUN-REN Institute of Experimental Medicine
2007
Brain electrical activity is largely composed of oscillations at characteristic frequencies. These rhythms are hierarchically organized and thought to perform important pathological physiological functions. The slow wave a fundamental cortical rhythm that emerges in deep non-rapid eye movement sleep. In animals, the modulates delta, theta, spindle, alpha, beta, gamma ripple oscillations, thus orchestrating brain While can enhance epileptic manifestations, it also underlie essential...
Summary Objective In 2014 the European Union–funded E‐ PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed investigate current use of neuroimaging, electromagnetic source localization, imaging postprocessing procedures in participating centers. Methods A survey on clinical imaging, methods candidates distributed among 25 centers consortium. descriptive analysis performed, results were compared existing guidelines...
We explored the current practice with respect to neuropsychological assessment of surgical epilepsy patients in European centers, aim harmonizing and establishing common standards. Twenty-six centers members "E-PILEPSY" (a pilot network reference refractory surgery), were asked report status adults children via two different surveys. There was a consensus among these regarding role neuropsychology presurgical workup. Strong agreement found on indications (localization, epileptic...
Efficacy/tolerability of adjunctive brivaracetam (BRV) for focal-onset seizures (FOS) in patients aged ≥ 16 years was established randomized controlled trials. This study aimed to evaluate the effectiveness BRV (≥ years) with FOS with/without focal bilateral tonic–clonic daily clinical practice. A 12-month, prospective, real-world, noninterventional nine European countries (EP0077/NCT02687711). prescribed per practice and Summary Product Characteristics. Eligible had never received before...
Summary The endocannabinoid system plays a central role in retrograde synaptic communication, and controls both glutamatergic γ‐aminobutyric acid (GABA)ergic transmission via type 1 cannabinoid (CB1) receptor. Both sclerotic human hippocampi the chronic phase of pilocarpine‐induced epilepsy mice with sclerosis, CB1‐receptor–positive interneuron somata were preserved dentate gyrus CA1 area, density CB1‐immunostained fibers increased considerably molecular layer. This suggests that, although...
A large proportion of hippocampal afferents and efferents are relayed through the subiculum. It is also thought to be a key structure in generation maintenance epileptic activity; rhythmic interictal-like discharges were recorded previous studies subicular slices excised from temporal lobe epilepsy patients. In order investigate if how subiculum involved vivo, lateral electrical activity under anesthesia 11 drug-resistant patients undergoing lobectomy. Based on laminar field potential...
Many adolescent mothers are parenting young children under highly stressful conditions as they managing first-time parenthood, poverty, lack of housing, school and work, challenging peer familial relationships. Mobile health (mHealth) technology has the potential to intervene at various points in emotion regulation process provide them support for more adaptive emotional behavioral course their daily life.The goal this study was examine acceptability, feasibility, use patterns, mechanisms by...
To evaluate long-term (up to 5.5 years) safety, seizure reduction, and maintenance of efficacy the antiepileptic drug (AED) lacosamide as adjunctive treatment in an open-label extension trial (SP774; ClinicalTrials.gov: NCT00515619).Three hundred seventy-six adults with partial-onset seizures taking 1-3 AEDs enrolled following completion a double-blind lacosamide. During treatment, dosage (100-800 mg/day) and/or concomitant could be adjusted optimize tolerability control.Kaplan-Meier...
To examine the effects of age on different aspects temporal lobe seizure semiology.We performed a video analysis 605 archived seizures from 155 consecutive patients (age 10 months to 49 years) selected by freedom after lobectomy. Eighty had hippocampal sclerosis (HS). Beside semiological classification, we assessed dependency several axes semiology: (1) aura, (2) number lateralizing signs, occurrence ictal (3) emotional (4) autonomic symptoms, (5) automatisms, and (6) secondary...
Aims. To build up a coherent shared pathophysiology of NFLE and AP discuss the underlying functional network. Methods. Reviewing relevant published data we point out common features in semiology events, relations to macro- microstructural dynamism NREM sleep, cholinergic arousal mechanism genetic aspects. Results. We propose that pathological arousals accompanied by confused behavior with autonomic signs and/or hypermotor automatisms are expressions frontal function different degree, during...
Objective: We assessed the efficacy, safety, and tolerability of cannabidivarin (CBDV) as add-on therapy in adults with inadequately controlled focal seizures. Materials Methods: One hundred sixty-two participants (CBDV n=81; placebo n=81) were enrolled. After a 4-week baseline, titrated from 400 to 800 mg CBDV twice daily (b.i.d.) (or placebo) over 2 weeks, followed by 6 weeks stable dosing (at b.i.d.) 12-day taper period. The primary endpoint was change baseline seizure frequency during...
To describe an unusual clinical presentation of a patient with voltage-gated potassium channel Ab- positive, non-paraneoplastic limbic encephalitis.We performed video-EEG monitoring, structural MRI, (18)F-FDG-PET, (1)H-MRS, neuropsychological testing and antibody serology.A 42-year-old male presented in acute phase encephalitis confirmed by antibodies to channels. His pilomotor status was pharmacoresistant antiepileptic drugs, but responded corticosteroid azathioprine treatment. The MRI...
Memory deficits are frequent among patients with epilepsies affecting the temporal lobe. Hippocampal interictal epileptic discharges (hIEDs), presumed exaggeration of sharp wave-ripples (SWRs), known to contribute memory dysfunction, but potential underlying mechanism is unknown. The precise coordination between hippocampal SWRs and corticothalamic spindles during sleep critical for consolidation. Moreover, previous investigation indicated that hIEDs induce neocortical spindlelike...
Childhood absence epilepsy is an syndrome responding relatively well to the ketogenic diet with one-third of patients becoming seizure-free. Less restrictive variants classical diet, however, have been shown confer similar benefits. Beneficial effects high fat, low-carbohydrate diets are often explained in evolutionary terms. However, paleolithic itself which advocates a return human has not yet studied epilepsy.Here, we present case 7-year-old child successfully treated alone. In addition...
Summary Vagus nerve stimulation (VNS) is a nonpharmacologic therapeutic option for patients with intractable epilepsy. Better clinical outcomes were recorded in nonfocal and Lennox‐Gastaut syndrome (LGS). We conducted 2‐year, open label, prospective study to measure the seizure outcome of 26 VNS patients. The numbers assessed using clinician’s global impression scale (CGI) patient diaries. average reduction was 23% at first year 22% second year. Seizure more pronounced among than focal...