A5088336306- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Atomic and Subatomic Physics Research
- Transcranial Magnetic Stimulation Studies
- Medical Imaging Techniques and Applications
- Neonatal and fetal brain pathology
- Advanced NMR Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Fetal and Pediatric Neurological Disorders
- Electron Spin Resonance Studies
- MRI in cancer diagnosis
- Traumatic Brain Injury Research
- Glioma Diagnosis and Treatment
- Advanced Image Processing Techniques
- NMR spectroscopy and applications
- Neural and Behavioral Psychology Studies
- Ultrasound and Hyperthermia Applications
- Sparse and Compressive Sensing Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Non-Invasive Vital Sign Monitoring
St Thomas' Hospital
2018-2025
King's College London
2018-2025
University College London
2015-2024
Great Ormond Street Hospital
2014-2024
National Hospital for Neurology and Neurosurgery
2007-2024
NHS Lothian
2024
Engineering and Physical Sciences Research Council
2021-2023
Wellcome EPSRC Centre for Medical Engineering
2018-2022
The King's College
2022
Wellcome Centre for Human Neuroimaging
2014-2018
Cognitive functions such as working memory (WM) are emergent properties of large-scale network interactions. Synchronisation oscillatory activity might contribute to WM by enabling the coordination long-range processes. However, causal evidence for way shapes dynamics and behavior in humans is limited. Here we applied transcranial alternating current stimulation (tACS) exogenously modulate a right frontoparietal that supports WM. Externally induced synchronization improved performance when...
Generalised spike wave (GSW) discharges are the electroencephalographic (EEG) hallmark of absence seizures, clinically characterised by a transitory interruption ongoing activities and impaired consciousness, occurring during states reduced awareness. Several theories have been proposed to explain pathophysiology GSW role thalamus cortex as generators. In this work we extend existing hypothesizing for precuneus, brain region neglected in previous works on generation but already known be...
<h3>Background</h3> The main challenge in assessing patients with epilepsy for resective surgery is localising seizure onset. Frequently, identification of the irritative and onset zones requires invasive EEG. EEG correlated functional MRI (EEG-fMRI) a novel imaging technique which may provide information regard to these regions. In focal epilepsy, interictal epileptiform discharge (IED) blood oxygen dependent level (BOLD) signal changes were observed approximately 50% whom IEDs are...
Surgical treatment of focal epilepsy in patients with cortical dysplasia (FCD) is most successful if all epileptogenic tissue resected. This may not be evident on structural magnetic resonance imaging (MRI), so intracranial electroencephalography (icEEG) needed to delineate the seizure onset zone (SOZ). EEG-functional MRI (fMRI) can reveal interictal discharge (IED)-related hemodynamic changes irritative (IZ). We assessed value EEG-fMRI FCD-associated by examining relationship between...
Abstract Despite its widespread use in cognitive studies, there is still limited understanding of whether and how transcranial direct current stimulation (tDCS) modulates brain network function. To clarify physiological effects, we assessed function using functional magnetic resonance imaging (fMRI) simultaneously acquired during tDCS stimulation. Cognitive state was manipulated by having subjects perform a Choice Reaction Task or being at “rest.” A novel factorial design used to assess the...
Whole brain functional connectomes hold promise for understanding human activity across a range of cognitive, developmental and pathological states. So called resting-state (rs) MRI studies have contributed to the being considered at macroscopic scale as set interacting regions. Interactions are defined correlation-based signal measurements driven by blood oxygenation level dependent (BOLD) contrast. Understanding neurophysiological basis these is important in conveying useful information...
Focal cortical dysplasia is a congenital abnormality of development and the leading cause surgically remediable drug-resistant epilepsy in children. Post-surgical outcome improved by presurgical lesion detection on structural MRI. Automated computational techniques have focal dysplasias adults but not yet been effective when applied to developing brains. There therefore need develop reliable sensitive methods address particular challenges paediatric cohort. We developed classifier using...
Summary Objective In 2014 the European Union–funded E‐ PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed investigate current use of neuroimaging, electromagnetic source localization, imaging postprocessing procedures in participating centers. Methods A survey on clinical imaging, methods candidates distributed among 25 centers consortium. descriptive analysis performed, results were compared existing guidelines...
Simultaneous EEG–fMRI acquisitions in patients with epilepsy often reveal distributed patterns of Blood Oxygen Level Dependant (BOLD) change correlated epileptiform discharges. We investigated if electrical source imaging (ESI) performed on the interictal discharges (IED) acquired during fMRI acquisition could be used to study dynamics networks identified by BOLD effect, thereby avoiding limitations combining results from separate recordings. Nine selected (13 IED types identified) focal...
Purpose: Subtle structural abnormalities of frontal lobe gray and white matter have been described in cryptogenic idiopathic generalized epilepsies. The supplementary motor area (SMA) has a role control, its involvement during epileptic seizures is characterized by typical asymmetric tonic posturing. Moreover, networks are dysfunctional juvenile myoclonic epilepsy (JME). We tested the hypothesis that SMA connectivity altered focal (FLE) JME compared to healthy controls. Methods: Diffusion...
The analysis of neuronal avalanches supports the hypothesis that human cortex operates with critical neural dynamics. Here, we investigate relationship between cascades activity in electroencephalogram data, cognitive state, and reaction time humans using a multimodal approach. We recruited 18 healthy volunteers for acquisition simultaneous functional magnetic resonance imaging during both rest visuomotor task. compared distributions electroencephalogram-derived to reference power laws task...
Drug-resistant temporal lobe epilepsy (TLE) often requires thorough investigation to define the epileptogenic zone for surgical treatment. We used simultaneous interictal scalp EEG-fMRI evaluate its value predicting long-term postsurgical outcome.30 patients undergoing presurgical evaluation and proceeding (TL) resection were studied. Interictal epileptiform discharges (IEDs) identified on intra-MRI EEG build a model of haemodynamic changes. In addition, topographic electroencephalographic...
In Diffusion Weighted MR Imaging (DWI), the signal is affected by biophysical properties of neuronal cells and their relative placement, as well extra-cellular tissue compartments. Typically, microstructural indices, such fractional anisotropy (FA) mean diffusivity (MD), are based on a tensor model that cannot disentangle influence these parameters. Recently, Neurite Orientation Dispersion Density (NODDI) has exploited multi-shell acquisition protocols to diffusion contribution three NODDI...
Generalized spike-wave discharges in idiopathic generalized epilepsy are conventionally assumed to have abrupt onset and offset. However, rodent models, emerge during a dynamic evolution of brain network states, extending several seconds before after the discharge. In human epilepsy, simultaneous EEG functional MRI shows cortical regions may be active discharges, connectivity around not normal. Here, we investigated whether states. Using EEG-functional MRI, studied 43 patients 34 healthy...