A5064225406- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- Neural dynamics and brain function
- Medical Imaging Techniques and Applications
- Cell Image Analysis Techniques
- Bioinformatics and Genomic Networks
- Radiomics and Machine Learning in Medical Imaging
- Single-cell and spatial transcriptomics
- EEG and Brain-Computer Interfaces
- Fetal and Pediatric Neurological Disorders
- Health, Environment, Cognitive Aging
- Brain Tumor Detection and Classification
- Neuroscience and Neuropharmacology Research
- Congenital heart defects research
- Neonatal and fetal brain pathology
- Pharmacological Effects and Toxicity Studies
- Genomic variations and chromosomal abnormalities
- Medical Image Segmentation Techniques
- Genetic Associations and Epidemiology
- Glioma Diagnosis and Treatment
- Machine Learning in Healthcare
- Diet and metabolism studies
- Machine Learning in Materials Science
University College London
2016-2025
Great Ormond Street Hospital
2022-2025
King's College London
2024-2025
Wellcome Centre for Human Neuroimaging
2019-2024
National Hospital for Neurology and Neurosurgery
2019-2024
University of Cambridge
2015-2021
University of London
2021
Universidad de Londres
2021
Montreal Neurological Institute and Hospital
2018-2021
University College Lahore
2021
Significance Adolescence is a period of human brain growth and high incidence mental health disorders. Here, we show consistently in two MRI cohorts that changes adolescence were concentrated on the more densely connected hubs connectome (i.e., association cortical regions mediated efficient connectivity throughout structural network). Hubs less myelinated at 14 y but had faster rates myelination shrinkage 14- to 24-y period. This topologically focused process consolidation was associated...
While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements cognition. nonhuman primate research has demonstrated a close structure–function correspondence, relationship between and poorly understood humans, part because reliance on post mortem analyses, which cannot be directly related functional data. To overcome this barrier, we developed novel approach model similarity...
Human functional magnetic resonance imaging (fMRI) brain networks have a complex topology comprising integrative components, e.g. long-distance inter-modular edges, that are theoretically associated with higher biological cost. Here, we estimated intra-modular degree, degree and connection distance for each of 285 cortical nodes in multi-echo fMRI data from 38 healthy adults. We used the multivariate technique partial least squares (PLS) to reduce dimensionality relationships between these...
Abstract Neurodevelopmental disorders have a heritable component and are associated with region specific alterations in brain anatomy. However, it is unclear how genetic risks for neurodevelopmental translated into spatially patterned vulnerabilities. Here, we integrated cortical neuroimaging data from patients caused by genomic copy number variations (CNVs) gene expression healthy subjects. For each of the six investigated disorders, show that spatial patterns anatomy changes youth...
Common mechanisms in aging and obesity are hypothesized to increase susceptibility neurodegeneration, however, direct evidence support of this hypothesis is lacking. We therefore performed a cross-sectional analysis magnetic resonance image-based brain structure on population-based cohort healthy adults. Study participants were originally part the Cambridge Centre for Ageing Neuroscience (Cam-CAN) included 527 individuals aged 20–87 years. Cortical reconstruction techniques used generate...
MRI, enabling in vivo analysis of cortical morphology, offers a powerful tool the assessment brain development and pathology. One most ubiquitous measures used—the thickness cortex—shows abnormalities number diseases conditions, but functional biological correlates such alterations are unclear. If connotations structural MRI to be understood, we must strive clarify relationship between as their cytoarchitectural determinants. We therefore sought determine whether patterns mirror key motif...
Histological atlases of the cerebral cortex, such as those made famous by Brodmann and von Economo, are invaluable for understanding human brain microstructure its relationship with functional organization in brain. However, these existing limited to small numbers manually annotated samples from a single hemisphere, measured 2D histological sections. We present first whole-brain quantitative 3D laminar atlas cortex. It was derived at 20-micrometer isotropic resolution (BigBrain), using...
We studied an accelerated longitudinal cohort of adolescents and young adults (n = 234, two time points) to investigate dynamic reconfigurations in myeloarchitecture. Intracortical profiles were generated using magnetization transfer (MT) data, a myelin-sensitive magnetic resonance imaging contrast. Mixed-effect models depth specific intracortical demonstrated separate processes i) overall increases MT, ii) flattening the MT profile related enhanced signal mid-to-deeper layers, especially...
High-resolution fMRI in the sub-millimeter regime allows researchers to resolve brain activity across cortical layers and columns non-invasively. While these high-resolution data make it possible address novel questions of directional information flow within circuits, corresponding analyses are challenged by MRI artifacts, including image blurring, distortions, low SNR, restricted coverage. These challenges often result insufficient spatial accuracy conventional analysis pipelines. Here we...
Abstract Human brain organization involves the coordinated expression of thousands genes. For example, first principal component (C1) cortical transcription identifies a hierarchy from sensorimotor to association regions. In this study, optimized processing Allen Brain Atlas revealed two new components gene architecture, C2 and C3, which are distinctively enriched for neuronal, metabolic immune processes, specific cell types cytoarchitectonics, genetic variants associated with intelligence....
Focal cortical dysplasia is a congenital abnormality of development and the leading cause surgically remediable drug-resistant epilepsy in children. Post-surgical outcome improved by presurgical lesion detection on structural MRI. Automated computational techniques have focal dysplasias adults but not yet been effective when applied to developing brains. There therefore need develop reliable sensitive methods address particular challenges paediatric cohort. We developed classifier using...
Summary Objective Focal cortical dysplasia ( FCD ) is a major pathology in patients undergoing surgical resection to treat pharmacoresistant epilepsy. Magnetic resonance imaging MRI postprocessing methods may provide essential help for detection of . In this study, we utilized surface‐based morphometry and machine learning automated lesion mixed cohort with type II from 3 different epilepsy centers. Methods Sixty‐one histologically proven were included the study. The had been evaluated at...
Transmitter receptors constitute a key component of the molecular machinery for intercellular communication in brain. Recent efforts have mapped density diverse transmitter across human cerebral cortex with an unprecedented level detail. Here, we distill these observations into organizational principles. We demonstrate that receptor densities form natural axis cortex, reflecting decreases differentiation at laminar organization and sensory-to-association functional level. Along this axis,...
Histological sections offer high spatial resolution to examine laminar architecture of the human cerebral cortex; however, they are restricted by being 2D, hence only regions with sufficiently optimal cutting planes can be analyzed. Conversely, noninvasive neuroimaging approaches whole brain but have relatively low resolution. Consequently, correct 3D cross-cortical patterns never been mapped in histological sections. We developed an automated technique identify and analyze structure within...
Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; first which is ‘BigBrain’. Here, we review recent methodological advances for integration BigBrain with multi-modal neuroimaging and introduce a toolbox, ’BigBrainWarp’, that combines these developments. The aim BigBrainWarp simplify workflows support adoption best practices. This accomplished simple wrapper function allows users easily map data between standard MRI spaces....
Drug-resistant focal epilepsy is often caused by cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and impact lesion location on clinical presentation surgical outcome are largely unknown. We created a neuroimaging cohort patients with individually mapped FCDs to determine factors associated predictors postsurgical outcome.
Abstract One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MRI. FCDs are difficult to visualize on MRI but often amenable surgical resection. We aimed develop an open-source, interpretable, surface-based machine-learning automatically identify heterogeneous data epilepsy surgery centres worldwide. The Multi-centre Epilepsy...
Neurosurgery is a safe and effective form of treatment for select children with drug-resistant epilepsy. Still, there concern that it remains underutilized, seizure freedom rates have not improved over time. We investigated referral surgical practices, patient characteristics, postoperative outcomes the past two decades.
Neuropsychological impairments are common in children with drug-resistant epilepsy. It has been proposed that epilepsy surgery might alleviate these by providing seizure freedom; however, findings from prior studies have inconsistent. We mapped long-term neuropsychological trajectories before and after undergoing surgery, to measure the impact of disease course on functioning. performed a retrospective cohort study 882 who had undergone at Great Ormond Street Hospital (1990-2018). extracted...
The cerebral cortex underlies many of our unique strengths and vulnerabilities, but efforts to understand human cortical organization are challenged by reliance on incompatible measurement methods at different spatial scales. Macroscale features such as folding functional activation accessed through spatially dense neuroimaging maps, whereas microscale cellular molecular typically measured with sparse postmortem sampling. Here, we integrate these distinct windows brain building upon existing...
The human isocortex consists of tangentially organized layers with unique cytoarchitectural properties. These show spatial variations in thickness and cytoarchitecture across the neocortex, which is thought to support function through enabling targeted corticocortical connections. Here, leveraging maps 6 cortical based on 3D brain histology, we aimed quantitatively characterize systematic covariation laminar structure cortex its functional consequences. After correcting for effect curvature,...
Cortical arealization arises during neurodevelopment from the confluence of molecular gradients representing patterned expression morphogens and transcription factors. However, whether similar are maintained in adult brain remains unknown. Here, we uncover three axes topographic variation gene human that specifically capture previously identified rostral-caudal, dorsal-ventral, medial-lateral early developmental patterning. The interaction these spatiomolecular i) accurately reconstructs...
In vivo structural neuroimaging can reliably identify changes to cortical morphology and its regional variation but cannot yet relate these specific layers. We propose, however, that by synthesizing principles of organization, including relative contributions different layers sulcal gyral thickness, patterns in thickness across the sheet profiles layer functional hierarchies, it is possible develop indirect morphological measures as markers more cytoarchitectural changes. developed four...