A5075033995- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Neural dynamics and brain function
- Optical Imaging and Spectroscopy Techniques
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- EEG and Brain-Computer Interfaces
- Medical Image Segmentation Techniques
- MRI in cancer diagnosis
- Motor Control and Adaptation
- CCD and CMOS Imaging Sensors
- Visual perception and processing mechanisms
- Advanced Fluorescence Microscopy Techniques
- Advanced NMR Techniques and Applications
- Advanced X-ray Imaging Techniques
- Cell Image Analysis Techniques
- Nuclear Physics and Applications
- Neurological disorders and treatments
- NMR spectroscopy and applications
- Transcranial Magnetic Stimulation Studies
National Institutes of Health
2023-2025
National Institute of Mental Health
2015-2025
Maastricht University
2018-2024
Heidelberg University
2021-2024
University Hospital Heidelberg
2021-2024
University Medical Centre Mannheim
2021-2024
Netherlands Institute for Neuroscience
2023
Imaging Center
2019-2020
Max Planck Institute for Human Cognitive and Brain Sciences
2012-2019
Max Planck Society
2012-2019
High-resolution fMRI in the sub-millimeter regime allows researchers to resolve brain activity across cortical layers and columns non-invasively. While these high-resolution data make it possible address novel questions of directional information flow within circuits, corresponding analyses are challenged by MRI artifacts, including image blurring, distortions, low SNR, restricted coverage. These challenges often result insufficient spatial accuracy conventional analysis pipelines. Here we...
Abstract To increase granularity in human neuroimaging science, we designed and built a next-generation 7 Tesla magnetic resonance imaging scanner to reach ultra-high resolution by implementing several advances hardware. improve spatial encoding the image signal-to-noise ratio, developed head-only asymmetric gradient coil (200 mT m −1 , 900 T s ) with an additional third layer of windings. We integrated 128-channel receiver system 64- 96-channel arrays boost signal cerebral cortex while...
MRI methods sensitive to functional changes in cerebral blood volume (CBV) may map neural activity with better spatial specificity than standard (fMRI) based on oxygen level dependent (BOLD) effect. The purpose of this study was develop and investigate a vascular space occupancy (VASO) method high sensitivity CBV for use human brain at 7 Tesla (T).To apply 7T VASO, several high-field-specific obstacles must be overcome, e.g., low contrast-to-noise ratio (CNR) due convergence tissue T1 ,...
The human brain coordinates a wide variety of motor activities. On large scale, the cortical system is topographically organized such that neighboring body parts are represented by areas. This homunculus-like somatotopic organization along central sulcus has been observed using neuroimaging for as face, hands and feet. However, on finer invasive electrical stimulation studies show deviations from this suggest an organizing principle based actions rather than part moved. It not clear how...
When humans perceive a sensation, their brains integrate inputs from sensory receptors and process them based on expectations. The mechanisms of this predictive coding in the human somatosensory system are not fully understood. We fill basic gap our understanding processing somatosensation by examining layer-specific activity input feedback primary cortex (S1). acquired submillimeter functional magnetic resonance imaging data at 7T (n = 10) during task perceived, predictable, unpredictable...
Purpose Functional MRI (fMRI) at the mesoscale of cortical layers and columns requires both sensitivity specificity, latter which can be compromised if imaging method is affected by vascular artifacts, particularly draining veins pial surface. Recent studies have shown that cerebral blood volume (CBV) more specific to actual laminar locus neural activity than BOLD using standard gradient‐echo EPI sequences. Gradient spin‐echo (GRASE) has also greater specificity when compared with BOLD. Here...
Laminar fMRI at ultra-high magnetic field strength is typically carried out using the Blood Oxygenation Level-Dependent (BOLD) contrast. Despite its unrivalled sensitivity to detecting activation, BOLD contrast limited in spatial specificity due signals stemming from intra-cortical ascending and pial veins. Alternatively, regional changes perfusion (i.e., cerebral blood flow through tissue) are colocalised neuronal which can be non-invasively measured Arterial Spin Labelling (ASL) MRI. In...
The development of ultra high field fMRI signal readout strategies and contrasts has led to the possibility imaging human brain in vivo non-invasively at increasingly higher spatial resolutions cortical layers columns. One emergent layer-fMRI acquisition method with increasing popularity is cerebral blood volume sensitive sequence named vascular space occupancy (VASO). This approach been shown be mostly locally-specific changes laminar microvasculature, without unwanted biases trans-laminar...
Abstract Calibrated functional magnetic resonance imaging can remove unwanted sources of signal variability in the blood oxygenation level‐dependent (BOLD) response. This is achieved by scaling, using information from a perfusion‐sensitive scan during purely vascular challenge, typically induced gas manipulation or breath‐hold task. In this work, we seek for validation use resting‐state fluctuation amplitude ( RSFA ) as scaling factor to contributions BOLD Given peculiarity depth‐dependent...
Mesoscopic (0.1-0.5 mm) interrogation of the living human brain is critical for advancing neuroscience and bridging resolution gap with animal models. Despite variety MRI contrasts measured in recent years at mesoscopic scale, vivo quantitative imaging T2* has not been performed. Here we provide a dataset containing empirical measurements acquired 0.35 × mm3 voxel using 7 Tesla MRI. To demonstrate unique features high quality this dataset, generate flat map visualizations that reveal...
Abstract Functional MRI (fMRI) time series are inherently susceptible to the influence of respiratory variations. While many studies treat respiration as a source noise in fMRI, this study employs natural variations during high resolution (0.8 mm) fMRI at 7T formulate effect related map and then use reduce macrovascular bias for more laminar-specific measurement. Our results indicate that respiratory-related signal changes modulated by breath phase (breathing in/out or transition between...
The use of submillimeter resolution functional magnetic resonance imaging (fMRI) is increasing in popularity due to the prospect studying human brain activation non-invasively at scale cortical layers and columns. This method, known as laminar fMRI, inherently signal-to-noise ratio (SNR)-limited, especially lower field strengths, with dominant noise source being thermal origin. Furthermore, fMRI challenged signal displacements draining vein effects conventional gradient-echo blood oxygen...