A5025023405- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Atomic and Subatomic Physics Research
- Advanced Neuroimaging Techniques and Applications
- Face Recognition and Perception
- Visual perception and processing mechanisms
- Medical Imaging Techniques and Applications
- Advanced NMR Techniques and Applications
- Aesthetic Perception and Analysis
- Optical Imaging and Spectroscopy Techniques
- NMR spectroscopy and applications
- Cell Image Analysis Techniques
- Photoacoustic and Ultrasonic Imaging
- Liver Disease and Transplantation
- Face recognition and analysis
- Sport and Mega-Event Impacts
- Neurotransmitter Receptor Influence on Behavior
- Ear Surgery and Otitis Media
- Language and cultural evolution
- Neuroscience and Music Perception
- Advanced Fluorescence Microscopy Techniques
- Peripheral Neuropathies and Disorders
- Craniofacial Disorders and Treatments
- Microwave Imaging and Scattering Analysis
Resonance Research (United States)
2016-2025
University of Minnesota
2017-2025
University of Minnesota System
2024
Azienda USL di Bologna
2023
University of Glasgow
2010-2015
Cognitive Neuroimaging Lab
2011-2015
University of Fribourg
2013
Wellcome Centre for Human Neuroimaging
2010
Functional magnetic resonance imaging (fMRI) has become an indispensable tool for investigating the human brain. However, inherently poor signal-to-noise-ratio (SNR) of fMRI measurement represents a major barrier to expanding its spatiotemporal scale as well utility and ultimate impact. Here we introduce denoising technique that selectively suppresses thermal noise contribution experiment. Using 7-Tesla, high-resolution brain data, demonstrate improvements in key metrics functional mapping...
Abstract A single dose of psilocybin, a psychedelic that acutely causes distortions space–time perception and ego dissolution, produces rapid persistent therapeutic effects in human clinical trials 1–4 . In animal models, psilocybin induces neuroplasticity cortex hippocampus 5–8 It remains unclear how brain network changes relate to subjective lasting psychedelics. Here we tracked individual-specific with longitudinal precision functional mapping (roughly 18 magnetic resonance imaging visits...
Human beings are natural experts at processing faces, with some notable exceptions. Same-race faces better recognized than other-race faces: the so-called effect (ORE). Inverting impairs recognition more for any other inverted visual object: face inversion (FIE). Interestingly, FIE is stronger same- compared to faces. At electrophysiological level, elicit consistently delayed and often larger N170 upright However, whether component sensitive race still a matter of ongoing debate. Here we...
Human beings are remarkably skilled at recognizing faces, with the marked exception of other-race faces: so-called “other-race effect.” As reported nearly a century ago [Feingold CA (1914) Journal Criminal Law and Police Science 5:39–51], this face-recognition impairment is accompanied by popular belief that faces all look alike. However, neural mechanisms underlying high-level “perceptual illusion” still unknown. To address question, we recorded high-resolution electrophysiological scalp...
As the neuroimaging field moves towards detecting smaller effects at higher spatial resolutions, and faster sampling rates, there is increased attention given to deleterious contribution of unstructured, thermal noise. Here, we critically evaluate performance a recently developed reconstruction method, termed NORDIC, for suppressing noise using datasets acquired with various strengths, voxel sizes, task designs. Following minimal preprocessing, statistical activation (t-values) NORDIC...
Abstract Purpose Toward pushing the boundaries of ultrahigh fields for human brain imaging, we wish to evaluate experimentally achievable SNR relative ultimate intrinsic (uiSNR) at 10.5T, develop design strategies toward approaching latter, quantify magnetic field–dependent gains, and demonstrate feasibility whole‐brain, high‐resolution imaging this uniquely high field strength. Methods A dual row 16‐channel self‐decoupled transmit (Tx) receive (Rx) array was developed 10.5T using custom...
The use of submillimeter resolution functional magnetic resonance imaging (fMRI) is increasing in popularity due to the prospect studying human brain activation non-invasively at scale cortical layers and columns. This method, known as laminar fMRI, inherently signal-to-noise ratio (SNR)-limited, especially lower field strengths, with dominant noise source being thermal origin. Furthermore, fMRI challenged signal displacements draining vein effects conventional gradient-echo blood oxygen...
Abstract In our dynamic environments, predictive processing is vital for auditory perception and its associated behaviors. Predictive coding formalizes inferential processes by implementing them as information exchange across cortical layers areas. With laminar-specific blood oxygenation level dependent we measured responses to a cascading oddball paradigm, ground on the mesoscopic human architecture. We show that violation of predictions are potentially hierarchically organized with in...
Abstract Purpose To develop and characterize a 128‐channel head array for brain imaging at 10.5 T, evaluate signal‐to‐noise ratio (SNR) relative to ultimate intrinsic SNR (uiSNR) lower field strengths, demonstrate human anatomical functional with this unique magnetic high‐channel‐count array. Methods The coil consists of 16‐channel self‐decoupled loop transmit/receive (16Tx/Rx) 112‐loop receive‐only (Rx) insert. Interactions between the 16Tx/Rx 112Rx insert were mitigated using coaxial cable...
Human beings are experts at processing faces, with a striking impairment for other-race (OR) the so-called effect (ORE). Despite robustness of ORE behavioural level, Event Related Potential (ERP) studies have failed to consistently show sensitivity race early category-specific N170 component. The observed discrepancy between electrophysiological findings is currently unresolved. Such inconsistency could be related heterogeneity task constraints, as well lack control evident differences in...
To develop multichannel transmit and receive arrays towards capturing the ultimate-intrinsic-SNR (uiSNR) at 10.5 Tesla (T) to demonstrate feasibility potential of whole-brain, high-resolution human brain imaging this high field strength.
High spatial and temporal resolution across the whole brain is essential to accurately resolve neural activities in fMRI. Therefore, accelerated imaging techniques target improved coverage with high spatio-temporal resolution. Simultaneous multi-slice (SMS) combined in-plane acceleration are used large studies that involve ultrahigh field fMRI, such as Human Connectome Project. However, for even higher rates, these methods cannot be reliably utilized due aliasing noise artifacts. Deep...
Abstract Functional MRI (fMRI) data are severely distorted by magnetic field (B0) inhomogeneities which currently must be corrected using separately acquired map data. However, changes in the head position of a scanning participant across fMRI frames can cause B0 field, preventing accurate correction geometric distortions. Additionally, maps corrupted movement during their acquisition, distortion altogether. In this study, we use phase information from multi-echo (ME) to dynamically sample...
Irreversible facial paralysis can be surgically treated by importing both a new neural and motor muscle supply. Various donor nerves used. If nerve supply other than the is used, patient has to adapt generate smile. branches of fifth cranial are learn clench teeth Currently, controversy exists regarding whether develops spontaneous smile if The authors postulate that brain adaptation in palsy patients occur because plasticity. aimed determine functional magnetic resonance imaging could...
Abstract At ultra-high field, fMRI voxels can span the sub-millimeter range, allowing recording of blood oxygenation level dependent (BOLD) responses at fundamental units neural computation, such as cortical columns and layers. This resolution, however, is only nominal in nature a number factors limit spatial acuity functional voxels. Multivoxel Pattern Analysis (MVPA) may provide means to detect information finer scales that otherwise not be visible single voxel due limitations sensitivity...
ABSTRACT Purpose To develop and characterize the performance of a 128-channel head array for brain imaging at 10.5 tesla evaluate potential this unique, >10 magnetic field. Methods The coil is composed 16-channel self-decoupled loop transmit/receive with 112-loop receive-only (Rx) insert. Interactions between outer transmitter inner 112Rx insert were mitigated using coaxial cable traps placed every 1/16 wavelength on each feed cable, locating most preamplifier boards outside field...
ABSTRACT One of the most important new frontiers in effort to improve spatial resolution and accuracy imaging human brain activity is recent development greater than 10 Tesla magnetic fields. Here we present initial results for 10.5 Blood Oxygenation Level Dependent (BOLD) based functional (fMRI) acquired with previously unavailable or difficult attain resolutions contrast. We data obtained nominal isotropic ranging from 0.65 0.35 mm partial coverage stimulus evoked responses, 0.75 whole...
fMRI provides spatial resolution that is unmatched by non-invasive neuroimaging techniques. Its temporal dynamics however are typically neglected due to the sluggishness of hemodynamic signal. We present multivariate pattern analysis (tMVPA), a method for investigating evolution neural representations in data, computed on single-trial BOLD time-courses, leveraging both and components implemented an expanding sliding window approach allows identifying time-window effect. demonstrate tMVPA can...
The brain is organized into distinct, flexible networks. Within these networks, cognitive variables such as attention can modulate sensory representations in accordance with moment-to-moment behavioral requirements. These modulations be studied by varying task demands; however, the tasks employed are often incongruent postulated functions of a system, limiting characterization system relation to natural behaviors. Here we combine domain-specific manipulations and ultra-high field fMRI study...
Functional MRI (fMRI) is commonly used for interpreting neural activities across the brain. Numerous accelerated fMRI techniques aim to provide improved spatiotemporal resolutions. Among these, simultaneous multi-slice (SMS) imaging has emerged as a powerful strategy, becoming part of large-scale studies, such Human Connectome Project. However, when SMS combined with in-plane acceleration higher rates, conventional reconstruction methods may suffer from noise amplification and other...
Abstract Functional magnetic resonance imaging (fMRI) has become one of the most powerful tools for investigating human brain. However, virtually all fMRI studies have relatively poor signal-to-noise ratio (SNR). Here we introduce a novel denoising technique, which suppresses noise that is indistinguishable from zero-mean, Gaussian-distributed noise. Thermal noise, falling in this category, major source fMRI, particularly, but not exclusively, at high spatial and/or temporal resolutions....