A5018978794- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Visual perception and processing mechanisms
- Advanced Neuroimaging Techniques and Applications
- Face Recognition and Perception
- Atomic and Subatomic Physics Research
- Color perception and design
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Ultrasound and Hyperthermia Applications
- Animal Behavior and Reproduction
- Hallucinations in medical conditions
- Multisensory perception and integration
- Optical Imaging and Spectroscopy Techniques
- Plant and animal studies
- Animal Vocal Communication and Behavior
- Primate Behavior and Ecology
- Mental Health and Psychiatry
- Medical Imaging Techniques and Applications
- Animal Behavior and Welfare Studies
- Genetic Associations and Epidemiology
- Color Science and Applications
- Neonatal and fetal brain pathology
- Photoacoustic and Ultrasonic Imaging
- Visual Attention and Saliency Detection
University of Minnesota
2019-2024
University of Minnesota System
2020-2024
Resonance Research (United States)
2019-2024
Allen Institute for Brain Science
2024
Institute of Behavioral Sciences
2021
Macquarie University
2013-2020
ARC Centre of Excellence in Cognition and its Disorders
2015-2020
Emory University
2016
Abstract Functional neuroimaging is an essential tool for neuroscience research. Pre-processing pipelines produce standardized, minimally pre-processed data to support a range of potential analyses. However, post-processing not similarly standardized. While several options exist, they may output from different pre-processing pipelines, have limited documentation, and follow generally accepted organization standards (e.g., Brain Imaging Data Structure (BIDS)). In response, we present XCP-D:...
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, emotional development beginning prenatally planned through early childhood. acquisition of multimodal magnetic resonance-based brain data is central to the study's core protocol. However, application Magnetic Resonance Imaging (MRI) methods in this population complicated by technical challenges difficulties imaging life. Overcoming...
Abstract Echo planar imaging (EPI) is widely used in functional and diffusion‐weighted MRI, but suffers from significant geometric distortions the phase encoding direction caused by inhomogeneities static magnetic field (B 0 ). This a particular challenge for EPI at very high (≥7 T), as distortion increases with higher strength. A number of techniques correction exist, including those based on B mapping acquiring scans opposite directions. However, few quantitative comparisons compensation...
Visual space is retinotopically mapped such that peripheral objects are processed in a cortical region outside the represents central vision. Despite this well-known fact, neuroimaging studies have found information about foveal confluence, representing fovea. Further, behaviorally relevant: disrupting confluence using transcranial magnetic stimulation impairs discrimination of at time-points consistent with disruption feedback. If receives feedback to boost vision, there should be...
Evidence from neuroimaging and brain stimulation studies suggest that visual information about objects in the periphery is fed back to foveal retinotopic cortex a separate representation essential for peripheral perception. The characteristics of this phenomenon have important theoretical implications role fovea-specific feedback might play In work, we employed recently developed behavioral paradigm explore whether late disruption central space impaired perception color. first experiment,...
Visual perception is abnormal in psychotic disorders such as schizophrenia. In addition to hallucinations, laboratory tests show differences fundamental visual processes including contrast sensitivity, center-surround interactions, and perceptual organization. A number of hypotheses have been proposed explain dysfunction disorders, an imbalance between excitation inhibition. However, the precise neural basis people with psychopathology (PwPP) remains unknown. Here, we describe behavioral 7...
Abstract Functional MRI (fMRI) data are severely distorted by magnetic field (B0) inhomogeneities which currently must be corrected using separately acquired map data. However, changes in the head position of a scanning participant across fMRI frames can cause B0 field, preventing accurate correction geometric distortions. Additionally, maps corrupted movement during their acquisition, distortion altogether. In this study, we use phase information from multi-echo (ME) to dynamically sample...
Abstract Extensive research has examined the effects of social isolation in neonatal and adult animal populations, but few studies have effect early adulthood. Animals reaching reproductive age often experience extensive changes as they leave their natal site, a stressor like may uniquely affect this group. Furthermore, adolescence is time when sex differences behavior become more pronounced. As such, stressors are likely to vary by sex. In study, we used noninvasive methods evaluate stress...
In the primate visual system, form (shape, location) and color information are processed in separate but interacting pathways. Recent access to high-resolution neuroimaging has facilitated exploration of structure these pathways at mesoscopic level human cortex. We used 7T fMRI observe selective activation primary cortex chromatic versus achromatic stimuli five participants across two scanning sessions. Achromatic checkerboards with low spatial frequency high temporal targeted...
The characterization of individual functional brain organization with Precision Functional Mapping has provided important insights in recent years adults. However, little is known about the ontogeny inter-individual differences during human development. Precise systems periods high plasticity likely to be essential for discoveries promoting lifelong health. Obtaining precision fMRI data development unique challenges that highlight importance establishing new methods improve acquisition,...
Abstract In high-field fMRI research, anatomical reference information (e.g., gray matter (GM) segmentation, cortical depth delineation) is often defined in volumes acquired with pulse sequences subject to different distortions than those functional volumes. these cases, reliable interpretation of ultra-high resolution data depends on excellent cross-modal registration this paper, we describe a two-step approach automating assessments quality for the purpose guiding depth-dependent analysis....
Heritability of regional subcortical brain volumes (rSBVs) describes the role genetics in middle and inner development. rSBVs are highly heritable adults but not characterized well adolescents. The Adolescent Brain Cognitive Development study (ABCD), taken over 22 US sites, provides data to characterize heritability struc-tures adolescence. In ABCD, site-specific effects co-occur with genetic which can bias estimates. Existing methods adjust-ing for site require additional steps adjust lead...
Visual perception is profoundly sensitive to context. Surround suppression a well-known visual context effect in which the firing rate of neuron suppressed by stimulation its extra-classical receptive field. The majority contrast surround studies exclusively use narrowband, sinusoidal grating stimuli; however, it unclear whether results produced such artificial stimuli generalize real-world, naturalistic experiences. To address this issue, we developed discrimination paradigm that includes...
Contour integration, the process of joining spatially separated elements into a single unified line, has consistently been found to be impaired in schizophrenia. Recent work suggests that this deficit could associated with psychotic symptomatology, rather than specific diagnosis such as Examining transdiagnostic sample participants psychopathology, we obtained quantitative indices contour perception psychophysical behavioral task. We discrimination performance among people psychopathology...
Motivation: The Healthy Brain and Child Development (HBCD) study is a longitudinal, multi-vendor, multi-site of early brain development, which will enroll ~7,500 infants. HBCD includes MRS within the imaging protocol. Goal(s): goal this abstract to present pilot data, identify any vendor site differences in data quality measured metabolite concentrations. Approach: were successfully acquired on 28 scanners, analyzed using Osprey 2.5.0, examine differences. Results: ANOVA results show minimal...
Motivation: Higher SNR promised at higher field strengths can be traded for spatial resolution, which is essential imaging infant brains. Goal(s): To assess and ensure safe operation of a commercially-available RF head coil 7T subjects. Approach: We developed an EM model the experimentally validated it. Utilizing simulations, we calculated local SARs to determine limits. Results: showed that SAR limit reached before limit. acquired structural functional MRI data from infant's brain 7T....
Motivation: Imaging infants with traditional voxel sizes is suboptimal due to their smaller brains. 7T imaging allows for higher spatial resolutions, while multi-echo fMRI provides optimal contrast across the brain. Goal(s): Establish feasibility of high-resolution in at 7T. Approach: Acquire data same infant 3T/7T within week, allowing direct comparisons, also considering unique safety guidelines imaging. Results: Initial demonstrate infant, establishing ME-fMRI high contrast, sensitivity,...
Abstract The characterization of individual functional brain organization with Precision Functional Mapping has provided important insights in recent years adults. However, little is known about the ontogeny inter-individual differences during human development. Precise systems periods high plasticity likely to be essential for discoveries promoting lifelong health. Obtaining precision fMRI data development unique challenges that highlight importance establishing new methods improve...
Abstract Echo planar imaging (EPI) is widely used in functional and diffusion-weighted MRI, but suffers from significant geometric distortions the phase encoding direction caused by inhomogeneities static magnetic field (B 0 ). This a particular challenge for EPI at very high (≥ 7T), as distortion increases with higher strength. A number of techniques correction exist, including those based on B mapping acquiring scans opposite directions. However, few quantitative comparisons compensation...