A5035193495- Functional Brain Connectivity Studies
- Substance Abuse Treatment and Outcomes
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Epigenetics and DNA Methylation
- Neurotransmitter Receptor Influence on Behavior
- Alcohol Consumption and Health Effects
- Advanced MRI Techniques and Applications
- Prenatal Substance Exposure Effects
- Personality Disorders and Psychopathology
- Medical Imaging Techniques and Applications
- Alcoholism and Thiamine Deficiency
- Health, Environment, Cognitive Aging
- Stress Responses and Cortisol
- Diet and metabolism studies
- Genetic Syndromes and Imprinting
- Terrorism, Counterterrorism, and Political Violence
- Alzheimer's disease research and treatments
- Advanced Differential Geometry Research
- Multiple Sclerosis Research Studies
- Birth, Development, and Health
- Health, psychology, and well-being
- Mental Health Treatment and Access
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
Children's Hospital of Philadelphia
2023-2025
University of Pennsylvania
2023-2025
Lifespan
2023-2025
Philadelphia University
2024
California University of Pennsylvania
2024
Penn Center for AIDS Research
2023
National Institutes of Health
2017-2020
National Institute on Alcohol Abuse and Alcoholism
2017-2020
Yale University
2016-2018
Abstract Human cortical maturation has been posited to be organized along the sensorimotor-association axis, a hierarchical axis of brain organization that spans from unimodal sensorimotor cortices transmodal association cortices. Here, we investigate hypothesis development functional connectivity during childhood through adolescence conforms hierarchy defined by axis. We tested this pre-registered in four large-scale, independent datasets (total n = 3355; ages 5–23 years): Philadelphia...
To investigate the potential role of alcohol use disorder (AUD) in aging processes, we employed Levine's epigenetic clock (DNAm PhenoAge) to estimate DNA methylation age 331 individuals with AUD and 201 healthy controls (HC). We evaluated effects heavy, chronic consumption on acceleration (EAA) using clinical biomarkers, including liver function test enzymes (LFTs) measures. characterize underlying genetic variation contributing EAA AUD, performed genome-wide association studies (GWAS) EAA,...
Childhood environments are critical in shaping cognitive neurodevelopment. With the increasing availability of large-scale neuroimaging datasets with deep phenotyping childhood environments, we can now build upon prior studies that have considered relationships between one or a handful environmental and features at time. Here, characterize combined effects hundreds inter-connected co-occurring child's environment ("exposome") investigate associations each unique, multidimensional pattern...
Abstract Functional neuroimaging is an essential tool for neuroscience research. Pre-processing pipelines produce standardized, minimally pre-processed data to support a range of potential analyses. However, post-processing not similarly standardized. While several options exist, they may output from different pre-processing pipelines, have limited documentation, and follow generally accepted organization standards (e.g., Brain Imaging Data Structure (BIDS)). In response, we present XCP-D:...
<h3>Importance</h3> The prevalence of high-intensity binge drinking (HIBD), defined as consuming 2 or more times the threshold by National Institute on Alcohol Abuse and Alcoholism (NIAAA), is rapidly increasing in United States. While relationship between alcohol consumption lipid liver function enzyme (LFT) biomarkers has been previously examined, associations HIBD with those remain unknown. <h3>Objective</h3> To examine LFT levels a cross-sectional sample enriched participants who engage...
Alcohol use disorder (AUD) is a chronic debilitating with limited treatment options and poorly defined pathophysiology. There are substantial genetic epigenetic components; however, the underlying mechanisms contributing to AUD remain largely unknown. We conducted largest DNA methylation epigenome-wide association study (EWAS) analyses currently available for (total N = 625) employed top hit replication (N 4798) using cross-tissue/cross-phenotypic approach goal of identifying novel targets...
Despite decades of neuroimaging research, how white matter develops along the length major tracts in humans remains unknown. Here, we identify fundamental patterns maturation by examining developmental variation major, long-range cortico-cortical youth ages 5-23 years using diffusion MRI from three large-scale, cross-sectional datasets (total N = 2,710). Across datasets, delineate two replicable axes human development. First, find a deep-to-superficial axis, which superficial tract regions...
Functional neuroimaging is an essential tool for neuroscience research. Pre-processing pipelines produce standardized, minimally pre-processed data to support a range of potential analyses. However, post-processing not similarly standardized. While several options exist, they tend output from disparate pre-processing pipelines, may have limited documentation, and follow BIDS best practices. Here we present XCP-D, which presents solution these issues. XCP-D collaborative effort between...
Background Recent studies have shown that alcohol use affects the regulation and expression of proprotein convertase subtilisin/kexin 9 (PCSK9). While a major role PCSK9 in hepatic function lipid has been clearly established, other pleiotropic effects remain poorly understood. Existing research suggests positive association between brain psychopathology, with increased levels cerebrospinal fluid (CSF) individuals dementia epigenetic modifications associated disorder (AUD). In this study, we...
High-intensity binge drinking (HIBD), defined as two or more times the gender-specific threshold, is rapidly increasing in USA; however, underlying contributing factors are poorly understood. This study investigated relationship of adverse childhood experiences (ACEs) and HIBD.
ABSTRACT Our minds and brains are highly unique. Despite the long-recognized importance of environment in shaping individual differences cognitive neurodevelopment, only with combination deep phenotyping approaches availability large-scale datasets have we been able to more comprehensively characterize many inter-connected features an individual’s experience (“exposome”). Moreover, despite clear evidence that brain organization is individualized, most neuroimaging studies still rely on group...
ABSTRACT Human cortical maturation has been posited to be organized along the sensorimotor-association (S-A) axis, a hierarchical axis of brain organization that spans from unimodal sensorimotor cortices transmodal association cortices. Here, we investigate hypothesis development functional connectivity during childhood through adolescence conforms hierarchy defined by S-A axis. We tested this pre-registered in four large-scale, independent datasets (total n = 3,355; ages 5-23 years):...
Symptoms of borderline personality disorder (BPD) often manifest in adolescence, yet the underlying relationship between these debilitating symptoms and development functional brain networks is not well understood. Here we aimed to investigate how multivariate patterns connectivity are associated with BPD a large sample young adults adolescents.
Abstract Aims Differences in DNA methylation of the serotonin transporter gene (SLC6A4) have been shown to alter SLC6A4 expression and predict brain functions healthy individuals. This study investigated association between promoter threat-related amygdala activation individuals with alcohol dependence (AD). Methods Methylation region was assessed using peripheral blood from 45 AD controls (HCs). All participants completed an emotional face matching task a 3-T magnetic resonance imaging...
Multiple sclerosis (MS) is an immune-mediated neurological disorder that affects 2.4 million people world-wide, and up to 60% experience anxiety.
Previous genetic association studies have shown that variation in the GATA4 gene encoding GATA binding protein 4, a binds to ANA sequence GATA, increase susceptibility for alcohol use disorder (AUD). In this study, we aimed replicate those findings an independent sample and analyze their with anxiety.Overall, 1044 individuals AUD [534 European American (EA), 510 African Americans (AA)] 645 controls [413 EA, 232 AA] were genotyped using 34 markers. Genotype allele frequencies compared between...
Background The gene encoding phosphatidylinositol‐4‐phosphate 5‐kinase ( PIP 5K1C ) has been recently implicated in pain regulation. Interestingly, a recent cross‐tissue and cross‐phenotypic epigenetic analysis identified the same alcohol use disorder AUD ). Given high comorbidity between chronic pain, we hypothesized that genetic variation might contribute to susceptibility . Methods We conducted case–control association study of variants Association analyses 16 common single nucleotide...