A5002375672- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Health, Environment, Cognitive Aging
- Multiple Sclerosis Research Studies
- Neural dynamics and brain function
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Obstructive Sleep Apnea Research
- Advanced MRI Techniques and Applications
- Airway Management and Intubation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Sports injuries and prevention
- EEG and Brain-Computer Interfaces
- Sensory Analysis and Statistical Methods
- Anesthesia and Pain Management
- Advanced Causal Inference Techniques
- Patient-Provider Communication in Healthcare
- Winter Sports Injuries and Performance
- Genetic Associations and Epidemiology
- Statistical Methods in Clinical Trials
- Time Series Analysis and Forecasting
- Natural Language Processing Techniques
Temple University
2023-2025
Temple College
2024-2025
University of Pennsylvania
2020-2023
Penn Center for AIDS Research
2021-2022
Center for Discrete Mathematics and Theoretical Computer Science
2022
Georgetown University
2021
Icahn School of Medicine at Mount Sinai
2020
Paracelsus Medical University
2020
Cornell University
2018-2020
University of Colorado Anschutz Medical Campus
2020
Abstract The brain is organized into networks at multiple resolutions, or scales, yet studies of functional network development typically focus on a single scale. Here, we derive personalized across 29 scales in large sample youths (n = 693, ages 8–23 years) to identify multi-scale patterns re-organization related neurocognitive development. We found that developmental shifts inter-network coupling reflect and strengthen hierarchy cortical organization. Furthermore, observed scale-dependent...
Background With an ageing population, the demand for joint arthroplasties and burden of postoperative delirium is likely to increase. Given lack large-scale data, we investigated associations between perioperative risk factors in arthroplasty surgery. Methods This retrospective population-based cohort study, utilized national claims data from all-payer Premier Healthcare database containing detailed billing information >25% nationwide hospitalizations. Patients undergoing elective total...
Many key findings in neuroimaging studies involve similarities between brain maps, but statistical methods used to measure these have varied. Current state-of-the-art comparing observed group-level maps (after averaging intensities at each image location across multiple subjects) against spatial null models of maps. However, typically make strong and potentially unrealistic assumptions, such as covariance stationarity. To address issues, this article we propose using subject-level data a...
Postoperative delirium in hip fracture patients is common and associated with substantial morbidity consumption of resources.Using data from the USA, we aimed to examine relationship between postoperative (modifiable) peri-operative factors mentioned American Geriatrics Society Best Practice Statement on Delirium Older Adults, stratified by 'young old' (<80 years) 'old-old' (≥80 categories.Retrospective cohort study 2006 2016.Population-based claims USA.Patients undergoing 505 152 repairs...
Our earliest acquired words tend to reference concrete objects that can be seen, heard, touched, and felt. One hallmark of language maturation involves an ‘abstractness shift’ where is used convey intangible mental states, emotions, ideas. Much our understanding the trajectory concreteness in development ends at early adolescence informed by studies comprehension. We investigated effects production across span adulthood with a focus on conversation. tested two competing hypotheses about...
Much of our understanding language processing has been informed by controlled laboratory experiments abstracted from the real world demands naturalistic communication. Interactive use “in wild” involves synchronizing numerous verbal and non-verbal behaviors between interlocutors. Conversation partners synchronize production through modulations rate, amplitude, lexical-semantic complexity, affective tone, many other dimensions. remains to be learned about how measure linguistic alignment in...
Despite decades of neuroimaging research, how white matter develops along the length major tracts in humans remains unknown. Here, we identify fundamental patterns maturation by examining developmental variation major, long-range cortico-cortical youth ages 5-23 years using diffusion MRI from three large-scale, cross-sectional datasets (total N = 2,710). Across datasets, delineate two replicable axes human development. First, find a deep-to-superficial axis, which superficial tract regions...
Background Research cohort data suggest diagnostic delay in multiple sclerosis (MS) has diminished tandem with MS criteria revisions, yet other studies have not replicated this finding. Recent indicate misdiagnosis of initial symptoms is a frequent contributor to delay. Objectives This survey study assessed and an patient registry. Methods Participants completed the between November 12, 2021, through December 22, 2021. Results There were 428 participants. Diagnostic was median 2.0 months...
Background: Few studies have addressed the results of educational efforts concerning proper use McDonald criteria (MC) revisions outside multiple sclerosis (MS) subspecialty centers. Neurology residents and MS subspecialist neurologists demonstrated knowledge gaps for core elements MC in a recent prior study. Objective: To assess comprehension application by non-MS specialist United States who routinely diagnose MS. Methods: Through cross-sectional study design, previously developed survey...
Abstract Functional networks often guide our interpretation of spatial maps brain–phenotype associations. However, methods for assessing enrichment associations within interest have varied in terms both scientific rigor and underlying assumptions. While some approaches relied on subjective interpretations, others made unrealistic assumptions about properties imaging data, leading to inflated false positive rates. We seek address this gap existing methodology by borrowing insight from a...
Previous research suggests that increased duration and lower levels of intraoperative hypotension (IOH) are associated with postoperative acute kidney injury (AKI). However, this association has not been evaluated in the context controlled (IOCH), a practice linked past to improved outcomes respect blood loss transfusion needs. This study aimed investigate whether IOCH is AKI among total hip arthroplasty patients at an institution where technique commonly practiced.We performed retrospective...
When individual subjects are imaged with multiple modalities, biological information is present not only within each modality, but also between modalities - that is, in how covary at the voxel level. Previous studies have shown local covariance structures or intermodal coupling (IMCo), can be summarized for two and two-modality IMCo reveals otherwise undiscovered patterns neurodevelopment certain diseases. However, previous methods based on slopes of weighted linear regression lines, which...
Purpose: The popularity of soccer worldwide is unquestionable, yet the aspect purposeful heading in sport has drawn increasing scrutiny over past 10 years. reason for this primarily be-cause concern potential deleterious effects repetitive head impacts (RHI) on brain structure and function. Accurate accounts header burden are needed to determine how frequently activity occurs during practice competition. Utilizing robust prospective database, report provides a significant look into exposure...
Patients with multiple sclerosis (MS) were vulnerable to the effects of physical inactivity during COVID-19 pandemic. As patients returned in-person visits, providers reported seeing increased weakness, balance issues, falls, worsening pain, and spasticity. Social isolation also contributed stress, depression, anxiety. This study explored whether attending virtual wellness programs was associated improvements in standard quality life questionnaire scores for MS.The purposive convenience...
Background and objectives Obstructive sleep apnea (OSA) is a risk factor for adverse postoperative outcome perioperative professional societies recommend the use of regional anesthesia to minimize detriment. We studied impact OSA on complications in high-volume orthopedic surgery practice, with strong focus anesthesia. Methods After Institutional Review Board approval, 41 766 cases primary total hip knee arthroplasties (THAs/TKAs) from 2005 2014 were extracted institutional data Hospital...
SUMMARY The brain is organized into networks at multiple resolutions, or scales, yet studies of functional network development typically focus on a single scale. Here, we derived personalized across 29 scales in large sample youths (n=693, ages 8-23 years) to identify multi-scale patterns re-organization related neurocognitive development. We found that developmental shifts inter-network coupling systematically adhered and strengthened hierarchy cortical organization. Furthermore, observed...
Abstract Many key findings in neuroimaging studies involve similarities between brain maps, but statistical methods used to measure these have varied. Current state-of-the-art comparing observed group-level maps (after averaging intensities at each image location across multiple subjects) against spatial null models of maps. However, typically make strong and potentially unrealistic assumptions, such as covariance stationarity. To address issues, this paper we propose using subject-level...
Summary Neuroimaging data are an increasingly important part of etiological studies neurological and psychiatric disorders. However, mitigating the influence nuisance variables, including confounders, remains a challenge in image analysis. In Alzheimer’s disease, for example, imbalance disease rates by age sex may make it difficult to distinguish between structural patterns brain (as measured neuroimaging scans) attributable progression those characteristic typical human aging or...