A5066151139- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Advanced Neuroimaging Techniques and Applications
- Autoimmune Neurological Disorders and Treatments
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Immunotherapy and Immune Responses
- Acute Lymphoblastic Leukemia research
- Retinal and Optic Conditions
- Cytokine Signaling Pathways and Interactions
- Health Systems, Economic Evaluations, Quality of Life
- Mycobacterium research and diagnosis
- Ionosphere and magnetosphere dynamics
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Autoimmune and Inflammatory Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Reproductive System and Pregnancy
- Monoclonal and Polyclonal Antibodies Research
- Neurogenesis and neuroplasticity mechanisms
- Bone and Joint Diseases
- Ultrasound and Hyperthermia Applications
- Hereditary Neurological Disorders
- Solar and Space Plasma Dynamics
Washington University in St. Louis
2016-2025
Vall d'Hebron Hospital Universitari
2019-2023
Johns Hopkins University
2019-2023
Universitat Autònoma de Barcelona
2023
Biogen (United States)
2021
Cleveland Clinic
2015-2021
University of Basel
2020
McGill University
2020
University of California, San Francisco
2020
Montreal Neurological Institute and Hospital
2020
To characterize patients misdiagnosed with multiple sclerosis (MS).Neurologists at 4 academic MS centers submitted data on determined to have been MS.Of 110 patients, 51 (46%) were classified as "definite" and 59 (54%) "probable" misdiagnoses according study definitions. Alternate diagnoses included migraine alone or in combination other 24 (22%), fibromyalgia 16 (15%), nonspecific nonlocalizing neurologic symptoms abnormal MRI 13 (12%), conversion psychogenic disorders 12 (11%),...
<h3>Background</h3> B cells are implicated in the pathogenesis of multiple sclerosis. A beneficial effect B-cell depletion using rituximab has been shown, but complete mechanism action for this drug is unclear. <h3>Objective</h3> To determine relationship between T and changes cerebrospinal fluid (CSF) chemokine levels with rituximab, a monoclonal antibody that targets CD20. <h3>Design</h3> Phase 2 trial as an add-on therapy. <h3>Setting</h3> The John L. Trotter Multiple Sclerosis Center,...
There are limited treatments for progressive multiple sclerosis. Ibudilast inhibits several cyclic nucleotide phosphodiesterases, macrophage migration inhibitory factor, and toll-like receptor 4 can cross the blood-brain barrier, with potential salutary effects in
The radiologically isolated syndrome (RIS) represents the earliest detectable pre-clinical phase of multiple sclerosis (MS). This study evaluated impact therapeutic intervention in preventing first symptom manifestation at this stage disease spectrum.We conducted a multi-center, randomized, double-blinded, placebo-controlled involving people with RIS. Individuals without clinical symptoms typical MS but incidental brain MRI anomalies consistent central nervous system (CNS) demyelination were...
Triggering receptor expressed on myeloid cells 2 (TREM-2) is a membrane-bound by microglia and macrophages. Engagement of TREM-2 these has been reported to reduce inflammatory responses and, in microglial cells, promote phagocytosis. function critical within the CNS, as its genetic deficiency humans causes neurodegeneration with myelin axonal loss. Blockade worsened mouse model for multiple sclerosis. In present study, soluble form protein identified immunoprecipitation ELISA. Soluble...
B cells and the humoral immune system have been implicated in pathogenesis of multiple sclerosis (MS). This study sought to evaluate efficacy, safety, tolerability add-on therapy with rituximab, a monoclonal antibody that depletes circulating cells, subjects relapsing MS breakthrough disease defined by clinical MRI activity (Class III evidence).Thirty relapse within past 18 months despite use an injectable disease-modifying agent, at least 1 gadolinium-enhancing (GdE) lesion on any 3...
Neuromyelitis optica (NMO) is associated with destructive inflammatory lesions, resulting in necrosis and axonal injury. Disability from multiple sclerosis (MS) due to a combination of demyelination varying involvement. Optical coherence tomography (OCT), by measuring retinal nerve fiber layer (RNFL) as surrogate injury, has potential discriminate between these two conditions.Included were 22 subjects NMO or spectrum disorders 47 MS. Seventeen all MS had remote history optic neuritis (ON) at...
Axon injury/loss, demyelination and inflammation are the primary pathologies in multiple sclerosis lesions. Despite prevailing notion that axon/neuron loss is substrate of clinical progression sclerosis, roles these individual pathological processes play remain to be defined. An imaging modality capable effectively detect, differentiate individually quantify axon inflammation, would not only facilitate understanding pathophysiology underlying progression, but also assessment treatments at...
Background: Patients with neuromyelitis optica (NMO) and multiple sclerosis (MS) both can present acute optic neuritis (ON), while differing considerably in their prognosis management. The clinical course, serologic testing results, brain spinal cord imaging of these diseases have been well documented. purpose this study was to look systematically for any differences the appearance nerve NMO MS-related ON. Methods: Magnetic resonance (MRI) orbits obtained within 6 weeks ON patients securely...
Determine the utility of optical coherence tomography (OCT) to detect clinical and subclinical remote optic neuritis (ON), its relationship characteristics ON visual function, whether retinal nerve fiber layer (RNFL) thickness functions as a surrogate marker global disease severity.Cross-sectional study 65 subjects with at least 1 episode 6 months prior. Measures included characteristics, acuity (VA), contrast sensitivity (CS), OCT, evoked potentials (VEP).Ninety-six clinically affected...
<h3>Objective</h3> To assess over 3 years of follow-up the effects maintaining or switching to ocrelizumab (OCR) therapy on clinical and MRI outcomes safety measures in open-label extension (OLE) phase pooled OPERA: I/II studies relapsing multiple sclerosis. <h3>Methods</h3> After 2 double-blind, controlled treatment, patients continued OCR (600 mg infusions every 24 weeks) switched from interferon (IFN)-β-1a (44 μg times weekly) when entering OLE (3 years). Adjusted annualized relapse rate,...
The present communication deals with radio observations made by British workers as part of the general geophysical investigation polar regions carried out during Second International Polar Year, 1 August, 1932, to 31 1933. In long period which has elapsed since first Year 1882-83, field inquiry been greatly extended use improved methods and instruments. Such advances have especially notable in atmospheric physics. Among new developed we may count waves for exploration upper-atmospheric...
CXCL13, a B-cell chemokine, has been proposed as biomarker in variety of conditions, some which can mimic multiple sclerosis and have very high levels. In this case-control study, cerebrospinal fluid (CSF) CXCL13 was elevated sclerosis, neuromyelitis optica other inflammatory neurological controls compared with noninflammatory controls. Levels did not differentiate disease groups. For all subjects taken together, CSF correlated WBC, oligoclonal band numbers, protein, EDSS, neurofilament...
Diroximel fumarate (DRF) is a novel oral approved in the USA for relapsing forms of multiple sclerosis. DRF converted to monomethyl fumarate, pharmacologically active metabolite dimethyl (DMF). 462 mg and DMF 240 produce bioequivalent exposure are therefore expected have similar efficacy/safety profiles; distinct chemical structure may contribute its tolerability profile. The objective this study was compare gastrointestinal over 5 weeks patients with relapsing–remitting EVOLVE-MS-2 phase...
Dimethyl fumarate (DMF), a disease-modifying therapy for multiple sclerosis (MS), causes lymphopenia in fraction of patients. The clinical significance this is unknown. Several cases progressive multifocal leukoencephalopathy lymphopenic fumarate-treated patients have raised concerns about drug safety. Since lymphocytes contribute to MS pathology, may also be biomarker response the drug.The objective manuscript evaluate risk factors DMF-induced and failure real-world population patients.We...
Emerging evidence underlines the importance of micro(mi)RNAs in pathogenesis multiple sclerosis (MS). Free-circulating miRNAs were investigated serum from MS patients compared to controls. Statistically significant decreased levels miR-15b, miR-23a and miR-223 observed ( p < 0.05). Results validated replicated two further independent populations. A direct correlation between miRNA EDSS score was determined PPMS 0.007). The generalized trend toward down-regulation could result...
In a previous communication an account was given of some measurements upper atmospheric ionization in south-east England made by the critical frequency method. These were confined principally to Kennelly-Heaviside region (region E) and showed that maximum at level ionosphere exhibits diurnal seasonal variation such as may be explained terms solar ionizing agency travelling rectilinearly. It found, for example, reaches about noon, falls off rapidly sunset approaches, continues decrease less...
Background: Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) is the first example of a learning health system in multiple sclerosis (MS). Methods: MS PATHS being conducted ten healthcare institutions three countries, each contributing standardized information acquired during routine care. Institutional participation required following: active patient census ≥500; at least one Siemens 3T magnetic resonance imaging scanner; willingness to standardize...
To determine the potential of directional diffusivities from diffusion tensor imaging (DTI) to predict clinical outcome optic neuritis (ON), and correlate with vision, optical coherence tomography (OCT), visual evoked potentials (VEP).Twelve cases acute isolated ON were imaged within 30 days onset followed prospectively. Twenty-eight subjects a remote history studied cross-sectionally. Twelve healthy controls for comparison. DTI data acquired at 3T surface coil 1.3 x mm(3) isotropic...