A5040252404- Model-Driven Software Engineering Techniques
- Parkinson's Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Advanced Software Engineering Methodologies
- Software Engineering Research
- Service-Oriented Architecture and Web Services
- Neurological disorders and treatments
- Global trade and economics
- Marine Bivalve and Aquaculture Studies
- Restless Legs Syndrome Research
- Amyotrophic Lateral Sclerosis Research
- Acute Lymphoblastic Leukemia research
- Hydraulic Fracturing and Reservoir Analysis
- Digital Radiography and Breast Imaging
- Health, Environment, Cognitive Aging
- Oil and Gas Production Techniques
- Marine Biology and Ecology Research
- Software System Performance and Reliability
- Scientific Computing and Data Management
- Radiomics and Machine Learning in Medical Imaging
- Marine and fisheries research
- Advanced X-ray and CT Imaging
- Business Process Modeling and Analysis
- Mycobacterium research and diagnosis
- Formal Methods in Verification
Biogen (United States)
2012-2023
National Institute of Water and Atmospheric Research
2013-2022
Johns Hopkins Medicine
2008-2015
Johns Hopkins University
2004-2015
University of York
2010-2014
Prairie View A&M University
2013
Center for Drug Evaluation and Research
2012-2013
St. Vincent's University Hospital
2006-2012
University of Maryland Medical Center
2012
Georgetown University
2012
Abstract Anxiety disorders are common in Parkinson's disease (PD), but not well characterized. This study determined the prevalence and clinical correlates of all DSM‐IV‐TR anxiety disorder diagnoses a sample 127 subjects with idiopathic PD who underwent comprehensive assessments administered by psychiatrist neurologist. A panel six psychiatrists expertise geriatric psychiatry and/or movement established consensus psychiatric diagnoses. Current lifetime at least one diagnosis was 43% (n =...
The effect of the initial substrate surface condition, as indicated by critical tension for wetting, on rate attachment marine bacteria to a variety solid surfaces has been measured. techniques used determine number attached per unit area were lipopolysaccharide test utilizing Limulus lysate and direct examination scanning electron microscopy. results obtained two are compared their significance control microbiological slime film formation (microfouling) is discussed.
<b><i>Objective:</i></b> To determine the prevalence and impact of comorbid psychiatric disturbances in Parkinson disease (PD) patients with psychosis. <b><i>Methods:</i></b> Subject data were derived from a research database 116 PD participating standardized motor, cognitive, psychiatric, caregiver assessments. <b><i>Results:</i></b> There 25 (22%) psychosis manifest as hallucinations (n = 9), delusions 1), or 15) who had no current past comorbidities (PDN). In psychotic group, 44% only...
In patients with Parkinson disease (PD), impulse control disorders (ICDs) such as hypersexuality and pathologic gambling shopping can be devastating complications of antiparkinsonian treatment. To improve their detection, we investigated clinical features associated ICDs. Subjects were participants in a longitudinal study PD. ICDs use dopamine agonists depressed mood, disinhibition, irritability, appetite disturbance.
Understanding the impact of noise on marine fauna at population level requires knowledge about vulnerability different life-stages. Here we provide first evidence that exposure during larval development produces body malformations in invertebrates. Scallop larvae exposed to playbacks seismic pulses showed significant developmental delays and 46% developed abnormalities. Similar effects were observed all independent samples while no found control groups (4881 examined). Malformations appeared...
The Methods of Optimal Depression Detection in Parkinson's Disease (MOOD-PD) study compared the psychometric properties 9 depression scales to provide guidance on scale selection Parkinson disease (PD).Patients with PD (n = 229) from community-based neurology practices completed 6 self-report (Beck Inventory [BDI]-II, Center for Epidemiologic Studies Rating Scale-Revised [CESD-R], 30-item Geriatric Scale [GDS-30], Depressive Symptoms-Patient [IDS-SR], Patient Health Questionnaire-9 [PHQ-9],...
Background: Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) is the first example of a learning health system in multiple sclerosis (MS). Methods: MS PATHS being conducted ten healthcare institutions three countries, each contributing standardized information acquired during routine care. Institutional participation required following: active patient census ≥500; at least one Siemens 3T magnetic resonance imaging scanner; willingness to standardize...
OBJECTIVES: To determine the incidence of distal radius fractures and characteristics those to identify key risk factors. DESIGN: Prospective cohort study, mean follow‐up 9.8 years. SETTING: Four clinical centers, one each in Baltimore, Maryland; Minneapolis, Minnesota; Pittsburgh, Pennsylvania; Portland, Oregon. PARTICIPANTS: Nine thousand seven hundred four white women aged 65 older, enrolled multicenter Study Osteoporotic Fractures. METHODS: Five twenty‐seven were confirmed by physician...
Abstract Executive dysfunction (ED) is a prominent and often disabling feature of cognitive impairment in Parkinson's disease (PD). Few studies have examined treatments. Given the role noradrenergic pathology ED, atomoxetine, norepinephrine reuptake inhibitor indicated for attention deficit hyperactivity disorder (ADHD), may be potential treatment PD‐related ED. Twelve patients with PD ED completed an 8‐week pilot open‐label, flexible dose (25–100 mg/day) trial atomoxetine. On primary...
Data taken from a steady-state electrolytic model have been used to developcurves showing production increase as f unction of fracture height, length, reservoir drainage radius, flow capacity, formation permeability and wellbore radius. The work allows fullerevaluation the effect fracturing parameters on productivityincrease. Introduction Hydraulic methods for productionstimulation become common procedure in oiland gas industry. Fracturing treatments areperformed wells various potentials...
Objective Depression in Parkinson disease (PD) is a common problem that worsens quality of life and causes disability. However, little known about the longitudinal impact depression on disability PD. This study examined association between DSM‐IV‐TR status across six years. Methods Longitudinal cohort with assessments at entry, year two, four, conducted Morris K. Udall Disease Research Center. Recruitment totaled 137 adult men women idiopathic PD which up to years data demographic, motor,...
In the clinic, assessment of patients with multiple sclerosis (MS) is typically qualitative and non-standardized. To describe MS Performance Test (MSPT), an iPad Air® 2 (Apple, Cupertino, CA, USA)-based neurological platform allowing to input relevant information without aid a medical technician, creating longitudinal, clinically meaningful, digital record. report results from human factor (HF) usability studies, initial large-scale implementation in practice setting. The HF study examined...
ABSTRACT Expression of the genes for membrane-bound F o sector Escherichia coli 1 proton-translocating ATPase can respond to changes in metabolic conditions, and these are reflected alterations subunit stoichiometry oligomeric proton channel. Transcriptional translational lacZ fusions promoter two show that, during growth on nonfermentable carbon source succinate, transcription operon translation uncB , encoding a higher than glucose. In contrast, uncE gene, c is glucose succinate....
Incompetent perforating veins in the leg were localized separately by clinical and thermographic methods. Clinically, methods used a multiple tourniquet test palpation for fascial defects. Thermographically, diagnosis of an incompetent perforator was made finding rapid heat flow to skin cooled limb with occlusion circulation superficial distally proximally. Exploration all sites marked clinically or thermographically showed that method detected 60%, missed 40%, gave false-positive results...
The purpose was to determine the test-retest reliability, practice effects, convergent validity and sensitivity multiple sclerosis (MS) disability of neuroperformance subtests from patient self-administered Multiple Sclerosis Performance Test (MSPT) designed assess low contrast vision (Contrast Sensitivity Test, CST), upper extremity motor function (Manual Dexterity MDT) lower (Walking Speed WST) introduce concept regression-based norms aid clinical interpretation performance scores using...
The use of multimedia in instructional presentations has mushroomed recent years due to the increased capabilities computers and inclusion most CBT authoring systems presentation tools. While providing a wealth opportunity developers, is often used ineffectively may cause decrease learning performance. Many claims have been made as added effectiveness that can bring training programs presentations. purpose this paper provide researched-based guidelines for be by developers not technologists.