A5033526894- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Mental Health Treatment and Access
- Advanced MRI Techniques and Applications
- Bipolar Disorder and Treatment
- Autism Spectrum Disorder Research
- Neuroscience and Music Perception
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Mental Health and Psychiatry
- Neural dynamics and brain function
- Cannabis and Cannabinoid Research
- Child Abuse and Trauma
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Genetic Neurodegenerative Diseases
- Biofield Effects and Biophysics
- Neurotransmitter Receptor Influence on Behavior
- Youth Substance Use and School Attendance
- Genetics and Neurodevelopmental Disorders
Minneapolis VA Health Care System
2023-2024
University of Minnesota
2019-2024
University of Minnesota System
2020-2023
University of Minnesota Medical Center
2019-2021
Minnesota State Colleges and Universities System
2021
University of Maryland, Baltimore County
2014-2019
Beth Israel Deaconess Medical Center
2015
Harvard University
2015
Abstract Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying layout. We tested large-scale structural in schizophrenia relate to normative and functional connectome architecture, systematically evaluated robustness generalizability of network-level alterations. Leveraging anatomical MRI scans from 2439 adults 2867 healthy controls 26 ENIGMA sites data...
Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts the ENIGMA, non-ENIGMA public datasets. Using Subtype Stage Inference (SuStaIn) algorithm, identify two distinct neurostructural subgroups by mapping spatial temporal ‘trajectory’ gray matter change in...
Investigations within the Human Connectome Project have expanded to include studies focusing on brain disorders. This paper describes one of investigations focused psychotic psychopathology: The psychosis (P-HCP). data collected as part this project were multimodal and derived from clinical assessments psychopathology, cognitive assessments, instrument-based motor blood specimens, magnetic resonance imaging (MRI) data. dataset will be made publicly available through NIMH Data Archive. In...
Abstract Background Schizophrenia is associated with hypoactivation of reward sensitive brain areas during anticipation. However, it unclear whether these neural functions are similarly impaired in other disorders psychotic symptomatology or individuals genetic liability for psychosis. If abnormalities shared across psychopathology and people heightened psychosis, there may be a common basis symptoms diminished pleasure motivation. Methods We compared performance activity 123 history...
Formal thought disorder (FTD) is a clinical key factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, relationship between FTD symptom dimensions and patterns of regional brain volume loss schizophrenia remains to be established large cohorts. Even less known about cellular basis FTD. Our study addresses these major obstacles by enrolling multi-site cohort acquired ENIGMA Schizophrenia Working Group (752 patients 1256 controls), unravel neuroanatomy...
Schizophrenia is characterized by abnormal brain structure such as global reductions in gray matter volume. Machine learning models trained to estimate the age of brains from structural neuroimaging data consistently show advanced brain-age be associated with schizophrenia. Yet, it unclear whether specific schizophrenia compared other psychotic disorders, and evidence that "older" than chronological actually reflects neurodevelopmental rather atrophic processes. It also unknown genetic...
Early identification efforts for psychosis have thus far yielded many more individuals "at risk" than actually develop psychotic illness. Here, we test whether measures of reinforcement learning (RL), known to be impaired in chronic schizophrenia, are related the severity clinical risk symptoms. Because reliance RL on dopamine-rich frontostriatal systems and evidence dopamine system dysfunction prodrome, specific interest this population. The current study examines relationships between...
Visual perception is abnormal in psychotic disorders such as schizophrenia. In addition to hallucinations, laboratory tests show differences fundamental visual processes including contrast sensitivity, center-surround interactions, and perceptual organization. A number of hypotheses have been proposed explain dysfunction disorders, an imbalance between excitation inhibition. However, the precise neural basis people with psychopathology (PwPP) remains unknown. Here, we describe behavioral 7...
Multivariate techniques better fit the anatomy of complex neuropsychiatric disorders which are characterized not by alterations in a single region, but rather variations across distributed brain networks. Here, we used principal component analysis (PCA) to identify patterns covariance regions and relate them clinical demographic variables large generalizable dataset individuals with bipolar controls. We then compared performance PCA clustering on identical sample methodology was capturing...
Practice guidelines emphasize frequent clinical monitoring of patients at high risk for psychosis. No brief instrument assessing attenuated psychotic symptoms has been validated this purpose. This study examined use three self-report questionnaires, which were developed as psychosis screeners, symptom severity in a naturalistic sample 54 adolescents.Self-report measures (Prime Screen-Revised, Prodromal Questionnaire-Brief Version [PQ-B], and Youth Psychosis At-Risk Questionnaire-Brief)...
Within schizophrenia, genetic factors contribute greatly to risk, yet testing for the disorder is not available. For some individuals with specific genotypes, cannabis use may increase risk of schizophrenia. It possible that tests could be offered in future inform schizophrenia if they cannabis. Previous research, however, provides little guidance on how young adults might respond such tests.We assessed a group (n = 83) determine perceived magnitude increased presence influences decisions...
Autism and psychosis share overlapping clinical features can occur comorbidly. Given growing recognition that early identification of risk symptoms may lead to better functional outcomes, the field needs valid tools for use in assessment within autism. This study employed a multi-method approach evaluate utility tool, Structured Interview Psychosis-Risk Syndromes, with adolescents A total 43 (N = 21 autism, N 22 typically developing) were interviewed using positive symptom domain Syndromes....
Abstract While schizophrenia is considered a prototypical network disorder characterized by widespread brain-morphological alterations, it still remains unclear whether distributed structural alterations robustly reflect underlying layout. Here, we tested large-scale in relate to normative and functional connectome architecture, systematically evaluated robustness generalizability of these network-level alterations. Leveraging anatomical MRI scans from 2,439 adults with 2,867 healthy...