A5054234763- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Psychedelics and Drug Studies
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Gut microbiota and health
- Diet and metabolism studies
- Neuroscience and Music Perception
- Memory and Neural Mechanisms
- Advanced MRI Techniques and Applications
- Eating Disorders and Behaviors
- Treatment of Major Depression
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- EEG and Brain-Computer Interfaces
- Attention Deficit Hyperactivity Disorder
- Health, Environment, Cognitive Aging
- Obsessive-Compulsive Spectrum Disorders
- Behavioral Health and Interventions
- Mental Health and Psychiatry
- Semantic Web and Ontologies
University of Basel
2016-2025
Universitäre Psychiatrische Kliniken Basel
2013-2025
University of Colorado Anschutz Medical Campus
2025
University of Colorado Denver
2025
University of Nebraska Medical Center
2025
University of Lübeck
2023
Kermanshah University of Medical Sciences
2023
Ludwig-Maximilians-Universität München
2023
Tehran University of Medical Sciences
2023
St. Claraspital
2023
Visual illusions and hallucinations are hallmarks of serotonergic hallucinogen-induced altered states consciousness. Although the hallucinogen psilocybin activates multiple serotonin (5-HT) receptors, recent evidence suggests that activation 5-HT2A receptors may lead to formation visual by increasing cortical excitability altering visual-evoked responses. To address this hypothesis, we assessed effects (215 μg/kg vs placebo) on both α oscillations regulate early P1 N170 potentials in healthy...
Social and occupational impairments contribute to the burden of psychosis depression. There is a need for risk stratification tools inform personalized functional-disability preventive strategies individuals in at-risk early phases these illnesses.To determine whether predictors associated with social role functioning can be identified patients clinical high-risk (CHR) states or recent-onset depression (ROD) using clinical, imaging-based, combined machine learning; assess geographic,...
Diverse models have been developed to predict psychosis in patients with clinical high-risk (CHR) states. Whether prediction can be improved by efficiently combining and biological broadening the risk spectrum young depressive syndromes remains unclear.To evaluate whether transition predicted CHR or recent-onset depression (ROD) using multimodal machine learning that optimally integrates neurocognitive data, structural magnetic resonance imaging (sMRI), polygenic scores (PRS) for...
Abstract A promising new treatment approach for major depressive disorder (MDD) targets the microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions affected in MDD. This first randomized controlled trial determine whether short-term, high-dose probiotic supplementation reduces symptoms along with gut microbial neural changes depressed patients. Patients current episodes took either a multi-strain supplement or placebo over 31 days additionally...
Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota depression have been observed in recent years, opening novel treatment avenues. Here, we present the first two with major depressive disorder ever treated fecal transplantation as add-on Both improved their symptoms 4 weeks after transplantation. Effects lasted up 8 patient. Gastrointestinal symptoms, constipation particular, were reflected microbiome...
Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting equivocal findings. We carried out largest case–control study structural asymmetries with MRI data from 5,080 affected individuals 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global regional cortical thickness, surface...
<h3>Background:</h3> In major depressive disorder (MDD), cognitive dysfunctions strongly contribute to functional impairments but are barely addressed in current therapies. Novel treatment strategies addressing symptoms depression needed. As the gut microbiota–brain axis is linked and cognition, we investigated effect of a 4-week high-dose probiotic supplementation on depression. <h3>Methods:</h3> This randomized controlled trial included 60 patients with MDD, whom 43 entered modified...
Abstract Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying layout. We tested large-scale structural in schizophrenia relate to normative and functional connectome architecture, systematically evaluated robustness generalizability of network-level alterations. Leveraging anatomical MRI scans from 2439 adults 2867 healthy controls 26 ENIGMA sites data...
LSD is an ambiguous substance, said to mimic psychosis and improve mental health in people suffering from anxiety depression. Little known about the neuronal correlates of altered states consciousness induced by this substance. Limited previous studies indicated profound changes functional connectivity resting state networks after administration LSD. The current investigation attempts replicate extend those findings independent sample. In a double-blind, randomized, cross-over study, 100 μg...
It has been proposed that the thalamocortical system is an important site of action hallucinogenic drugs and essential component neural correlates consciousness. Hallucinogenic such as LSD can be used to induce profoundly altered states consciousness, it thus interest test effects these on this system.100 μg was administrated orally 20 healthy participants prior fMRI assessment. Whole brain thalamic functional connectivity measured using ROI-to-ROI ROI-to-voxel approaches. Correlation...
Pretest risk estimation is routinely used in clinical medicine to inform further diagnostic testing individuals with suspected diseases. To our knowledge, the overall characteristics and specific determinants of pretest psychosis onset undergoing high (CHR) assessment are unknown.To investigate CHR develop externally validate a stratification model.Clinical register-based cohort study. Individuals were drawn from electronic, real-world, real-time records relating routine mental health care...
This paper presents a model-based investigation of mechanisms underlying the reduction mismatch negativity (MMN) amplitudes under NMDA-receptor antagonist ketamine. We applied dynamic causal modeling and Bayesian model selection to data from recent ketamine study roving MMN paradigm, using cross-over, double-blind, placebo-controlled design. Our was guided by predictive coding framework that unifies contemporary "adaptation" "model adjustment" theories. Comparing series models allowed for...
Brain imaging studies have identified robust changes in brain structure and function during the development of psychosis, but contribution abnormal connectivity to onset psychosis is unclear. Furthermore, antipsychotic treatment can modulate activity functional cognitive tasks.To investigate whether dysfunctional working memory (WM) predates parameters are related treatment.Dynamic causal modeling study magnetic resonance data.Participants were recruited from specialized clinic for early...
Stimulation of serotonergic neurotransmission by psilocybin has been shown to shift emotional biases away from negative towards positive stimuli. We have recently that reduced amygdala activity during threat processing might underlie psilocybin's effect on processing. However, it is still not known whether modulates bottom-up or top-down connectivity within the visual-limbic-prefrontal network underlying therefore analyzed our previous fMRI data using dynamic causal modeling and used...