A5000997517- Gut microbiota and health
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Health, psychology, and well-being
- Diet and metabolism studies
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Advanced Statistical Modeling Techniques
- Gastrointestinal motility and disorders
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Mental Health Treatment and Access
- Impact of Technology on Adolescents
- Mental Health and Psychiatry
- Obsessive-Compulsive Spectrum Disorders
- Clostridium difficile and Clostridium perfringens research
- Psychiatric care and mental health services
- Eating Disorders and Behaviors
- Opioid Use Disorder Treatment
- Behavioral Health and Interventions
University of Basel
2021-2025
Universitäre Psychiatrische Kliniken Basel
2024-2025
University of Lübeck
2023
Tehran University of Medical Sciences
2023
Kermanshah University of Medical Sciences
2023
St. Claraspital
2023
Abstract A promising new treatment approach for major depressive disorder (MDD) targets the microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions affected in MDD. This first randomized controlled trial determine whether short-term, high-dose probiotic supplementation reduces symptoms along with gut microbial neural changes depressed patients. Patients current episodes took either a multi-strain supplement or placebo over 31 days additionally...
Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota depression have been observed in recent years, opening novel treatment avenues. Here, we present the first two with major depressive disorder ever treated fecal transplantation as add-on Both improved their symptoms 4 weeks after transplantation. Effects lasted up 8 patient. Gastrointestinal symptoms, constipation particular, were reflected microbiome...
<h3>Background:</h3> In major depressive disorder (MDD), cognitive dysfunctions strongly contribute to functional impairments but are barely addressed in current therapies. Novel treatment strategies addressing symptoms depression needed. As the gut microbiota–brain axis is linked and cognition, we investigated effect of a 4-week high-dose probiotic supplementation on depression. <h3>Methods:</h3> This randomized controlled trial included 60 patients with MDD, whom 43 entered modified...
Probiotics are suggested to improve depressive symptoms via the microbiota-gut-brain axis. We have recently shown a beneficial clinical effect of probiotic supplementation in patients with depression. Their underlying neural mechanisms remain unknown.A multimodal neuroimaging approach including diffusion tensor imaging, resting-state functional MRI, and arterial spin labeling was used investigate effects four-weeks on fronto-limbic brain structure, function, perfusion whether these were...
Abstract We recently indicated that four-week probiotic supplementation significantly reduced depression along with microbial and neural changes in people depression. Here we further elucidated the biological modes of action underlying beneficial clinical effects probiotics by focusing on immune-inflammatory processes. The analysis included a total N = 43 participants depression, from which 19 received supplement 24 placebo over four weeks, addition to treatment as usual. Blood saliva were...
Anhedonia has been associated with abnormal reward-related striatal dopamine functioning in patients different psychiatric disorders. Here, we tested whether anhedonia expression mapped onto volume across several diagnoses. T1-weighted images from 313 participants including 89 healthy controls (HC), 22 opioid use disorder (OUD), 50 major depressive (MDD), 45 borderline personality (BPD), 49 first-episode psychosis (FEP), 43 cocaine (CUD) and 15 schizophrenia (SZ) were included. was assessed...
Introduction Individuals with exercise addiction (EA) report being unable to stop exercising despite its negative psychological, physical, or social impact. Due a lack of evidence, EA has so far not been officially recognized as behavioral addiction. Only one study exists, that investigated mental disorders in individuals by utilizing the Structured Clinical Interview for DSM-5 Disorders (SCID-5). The present followed up on this sample, providing first longitudinal data EA. Methods All...
Background: Serial dependencies in perceptual tasks have been suggested to reflect implicit priors derived from short-term history. A reduced weighting of has proposed as a mechanism underlying psychotic experiences such delusions and hallucinations. Here, we sought characterize the effects explicit on auditory decision-making their modulation by psychosis proneness.Results: Across two online experiments, 197 healthy participants completed an two-alternative forced-choice task standard...
Background: Serial dependencies in perceptual tasks have been suggested to reflect implicit priors derived from short-term history. A reduced weighting of has proposed as a mechanism underlying psychotic experiences such delusions and hallucinations. Here, we sought characterize the effects explicit on auditory decision-making their modulation by psychosis proneness.Results: Across two online experiments, 197 healthy participants completed an two-alternative forced-choice task standard...
Impulsivity transcends psychiatric diagnoses and is often related to anhedonia. This ad hoc cross-sectional investigation explored 1) whether self-reported trait impulsivity mapped onto a common structural brain substrate across healthy controls (HCs) patients, 2) in more exploratory fashion, anhedonia were each other shared overlapping correlates. Structural magnetic resonance imaging (sMRI) datasets from 234 participants including HCs (n = 109) patients with opioid use disorder (OUD, n...
<title>Abstract</title> We recently indicated that four-week probiotic supplementation significantly reduced depression along with microbial and neural changes in people depression. Here we further elucidated the biological modes of action underlying beneficial clinical effects probiotics by focusing on immune-inflammatory processes. The analysis included a total N=39 participants depression, from which N=18 received supplement N=21 placebo over four weeks, addition to treatment as usual....
Abstract Background Exercise dependence (ED) is characterised by behavioural and psychological symptoms that resemble those of substance use disorders. However, it remains inconclusive whether ED accompanied similar brain alterations as seen in Therefore, we investigated individuals with inactive control participants. Methods In this cross-sectional neuroimaging investigation, 29 assessed the Dependence Scale (EDS) 28 participants (max one hour exercising per week) underwent structural...
To investigate the cross-cultural feasibility of a new scale for assessing dysfunctional working models self and others, to evaluate its discriminative power.Schizophrenic patients (N=351), non-psychotic (N= 86) non-clinical subjects 511) collected in 10 centres completed DWM-S. Current psychopathology was assessed by means BPRS.Alpha coefficients were high all samples. Mean scores on DWM-S appeared be comparable countries, suggesting cross-national generalizability. No significant...
New treatment approaches for opioid-dependent patients include injectable opioid agonist with diacetylmorphine. While evidence has shown beneficial clinical effects of diacetylmorphine, it is still not clear how long-term diacetylmorphine affects the brain and whether functional changes are accompanied by improvements. Therefore, this prospective case-control study focuses on resting-state connectivity. We included (N = 22, age range 33-58, 16 males) treated healthy controls 9, 27-55, 5 that...