A5076346658- Opioid Use Disorder Treatment
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Substance Abuse Treatment and Outcomes
- Eating Disorders and Behaviors
- HIV, Drug Use, Sexual Risk
- Behavioral Health and Interventions
- Attention Deficit Hyperactivity Disorder
- Pain Management and Opioid Use
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Sleep and related disorders
- Treatment of Major Depression
- Pain Management and Placebo Effect
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Sexual function and dysfunction studies
- Health and Medical Studies
- Diet and metabolism studies
- Impact of Technology on Adolescents
- Sexuality, Behavior, and Technology
- Health Systems, Economic Evaluations, Quality of Life
- Clinical practice guidelines implementation
- Medical History and Research
- Physical Activity and Health
University of Basel
2021-2025
Universitäre Psychiatrische Kliniken Basel
2019-2025
University of British Columbia
2022-2025
Georg Simon Ohm University of Applied Sciences Nuremberg
1923-1941
Heroin-assisted treatment comprises the use of diacetylmorphine (pharmaceutical heroin) for individuals with severe opioid disorder. In Switzerland, take-home doses in heroin-assisted are more strictly regulated as compared to conventional agonist treatment. light COVID-19 pandemic, Swiss Federal Council provisionally adapted its policy, allowing longer prescriptions diacetylmorphine. Before beginning only occurred exceptional circumstances and under strict criteria patient eligibility....
Diamorphine, commonly known as heroin, is a semi-synthetic opioid analgesic. In the context of heroin-assisted treatment for opioid-dependent patients, diamorphine mostly administered intravenously. However, recent attention has shifted towards intranasal administration better-tolerated alternative to intravenous route. Here, we developed and validated rapid bioanalytical method simultaneous quantification its major metabolites 6-monoacetylmorphine, morphine, morphine-3-glucuronide,...
Introduction: Heroin-assisted treatment (HAT) involves the supervised administration of pharmaceutical heroin (diacetylmorphine, DAM), either injectable or oral, for individuals with severe opioid use disorder who have not achieved stabilization conventional agonist treatment. Despite its growing adoption, there is limited literature on phenomenon diversion in HAT. Diversion refers to redirecting legal prescription medications from their intended medical illegal unauthorised use. This study...
Introduction Individuals with exercise addiction (EA) report being unable to stop exercising despite its negative psychological, physical, or social impact. Due a lack of evidence, EA has so far not been officially recognized as behavioral addiction. Only one study exists, that investigated mental disorders in individuals by utilizing the Structured Clinical Interview for DSM-5 Disorders (SCID-5). The present followed up on this sample, providing first longitudinal data EA. Methods All...
Abstract Aims We measured the effects of public health‐oriented cannabis access compared with illegal market on use and related mental health outcomes in adult users. Design This was a two‐arm, parallel group, open‐label, randomized controlled trial. Follow‐up outcome measurement took place after 6 months. Setting The study conducted Basel‐Stadt, Switzerland. Participants A total 378 (aged ≥18 years) users were enrolled between August 2022 March 2023, although only 374 who completed baseline...
Abstract Background Heroin-assisted treatment (HAT) is effective for individuals with severe opioid use disorder (OUD) who do not respond sufficiently to other agonist treatments. It mostly offered injectable diacetylmorphine (DAM) or DAM tablets creating a barrier need the rapid onset of action but are either unable unwilling inject, primarily snort opioids. To explore another route administration, we evaluated safety and feasibility intranasal (IN) DAM. Methods This multicentre...
Background and Aims: Exercise addiction has not yet been designated as an addictive disorder in the DSM-5 due to a lack of detailed research. In particular, associations with other psychiatric diagnoses have received little attention. this study, individuals possible exercise are clinically assessed, order establish profile co-occurring disorders addiction. Methods: One hundred fifty-six who reported exercising more than 10 h week, continued do so despite illness or injury, were recruited...
Cannabis is the most widely used illicit substance. Various countries have legalized cannabis for recreational use. Evidence on health effects of regulation remains unclear and mainly based observational studies. To date, there no randomized controlled study evaluating impact use compared to market relevant indicators. The present ("Weed Care") first evaluate regulated access in pharmacies versus a waiting list control group representing problematic as well mental physical health.
Background As the most commonly used illicit substance, cannabis is gaining global acceptance through increasing legalization efforts. This shift intensifies need for research to guide policymakers and healthcare providers in harm reduction treatment strategies. Nonetheless, relationship between psychopathological symptoms use remains inadequately understood. Methods A sample of regular consumers completed self-reported assessments depression (Patient Health Questionnaire-9), anxiety...
Abstract Background Use of benzodiazepines (BZD) in patients receiving opioid agonist treatment (OAT) is common and associated with a variety negative health social outcomes. This cross-sectional study investigates the impact BZD use OAT on their quality life (QoL). Methods A convenience sample oral or heroin-assisted two outpatient centres Basel, Switzerland was investigated. Participants (n = 141) completed self-report questionnaires psychiatric symptoms psychological distress (The Symptom...
OAT is a well developed and successful treatment strategy for opioid dependant patients in Europe, which contributed significantly to the fight against HIV HCV pandemic an increased life expectancy this population. Building on experiences Austria, Germany Switzerland their model of care, objective study analyze changes patient structures identify necessary adaptations system care. We analysed national register‐based data from receiving during period spanning 2010 2020 (cases), Switzerland....
Intramuscular (IM) injection of drugs is associated with high rates injecting-related injuries and diseases. However, little known about the role this route administration in heroin-assisted treatment. The aim study was to determine prevalence IM diacetylmorphine complications as well explore patients' views opinions on topic underlying reasons for practice.The research site a Swiss outpatient treatment centre specialised We conducted in-depth interviews two patients who intramuscularly...
Abstract Background Traditional heroin-assisted treatment in Switzerland consists of oral and injectable diacetylmorphine (pharmaceutical heroin) administration. To date, no suitable option is available for patients who crave rapid onset (“rush”) but are either unable to inject or primarily sniff inhale illicit heroin. We present a patient successfully switched intranasal following several unsuccessful attempts. Case presentation A 29-year-old male with severe opioid use disorder, injection...
Abstract Background Buprenorphine is an effective and safe treatment for opioid use disorder, but the requirement moderate withdrawal symptoms to emerge prior initiation a significant barrier. Case Presentation We report on two cases of hospitalized patients with severe, active in which we initiated transdermal buprenorphine over 48 h, followed by administration single dose sublingual buprenorphine/naloxone then extended-release subcutaneous buprenorphine. The did not experience precipitated...
Abstract Background Heroin-assisted treatment has proven effective in reducing criminal offenses opioid dependent individuals. Few studies attempted to explain the observed crime reduction and reasons why these patients keep offending getting incarcerated have date not been explored. Methods Patients with a history of incarcerations during time participating heroin-assisted ( n = 22) were invited semi-structured, narrative interview. Findings evaluated Mayring’s qualitative content analysis...
Abstract Background Heroin-assisted treatment (HAT) is a proven effective option for individuals with severe opioid use disorder (OUD). In Switzerland, pharmaceutical heroin (diacetylmorphine, DAM) available in tablet form or as injectable liquid. This creates large barrier who require the rapid onset of effect but are either unable do not want to inject, primarily snort opioids. Early experimental data has demonstrated that intranasal DAM administration can be viable alternative intravenous...
People at risk of exercise addiction report increased symptoms psychopathology. The aim this study was to clinically assess the lifetime prevalence depressive disorders in individuals and determine whether tend precede or follow excessive exercising.Based on Exercise Dependence Scale-21, a total 31 categorized underwent Structured Clinical Interview for DSM-5 major disorder (MDD).The results showed 16 participants suffered from MDD. onset MMD occurred 10 after exercising 5 before exercising....