A5085301391- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Neuroendocrine regulation and behavior
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Tryptophan and brain disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroscience of respiration and sleep
- Functional Brain Connectivity Studies
- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Stress Responses and Cortisol
- Electroconvulsive Therapy Studies
- Child Abuse and Trauma
- Migration, Health and Trauma
- Autism Spectrum Disorder Research
- Evolutionary Psychology and Human Behavior
- Mental Health and Psychiatry
- Personality Disorders and Psychopathology
- Dermatology and Skin Diseases
- Attachment and Relationship Dynamics
- Adolescent and Pediatric Healthcare
- Mental Health Treatment and Access
- Posttraumatic Stress Disorder Research
King's College London
2016-2024
University of Florence
2016-2018
South London and Maudsley NHS Foundation Trust
2017
Psychosis is a heterogeneous psychiatric condition for which multitude of risk and protective factors have been suggested. This umbrella review aimed to classify the strength evidence associations between each factor psychotic disorders whilst controlling several biases. The Web Knowledge database was searched identify systematic reviews meta‐analyses observational studies examined socio‐demographic, parental, perinatal, later or antecedents disorders, included comparison group healthy...
Pretest risk estimation is routinely used in clinical medicine to inform further diagnostic testing individuals with suspected diseases. To our knowledge, the overall characteristics and specific determinants of pretest psychosis onset undergoing high (CHR) assessment are unknown.To investigate CHR develop externally validate a stratification model.Clinical register-based cohort study. Individuals were drawn from electronic, real-world, real-time records relating routine mental health care...
Abstract Background Brief Limited Intermittent Psychotic Symptoms (BLIPS) are key inclusion criteria to define individuals at ultra high risk for psychosis (UHR). Their diagnostic and prognostic significance is unclear. Objectives To address the baseline relationship between BLIPS ICD-10 categories examine longitudinal impact of clinical sociodemographic factors. Methods Prospective long-term study in UHR meeting criteria. Sociodemographic data, including diagnoses, were automatically drawn...
Abstract Background The long-term clinical validity of the At Risk Mental State (ARMS) for prediction non-psychotic mental disorders is unknown. Methods Clinical register-based cohort study including all individuals assessed by Outreach And Support in South London (OASIS) service (2002–2015). primary outcome was risk developing any disorder (psychotic or non-psychotic). Analyses included Cox proportional hazard models, Kaplan–Meier survival/failure function and C statistics. Results A total...
Abstract Background and Hypothesis This umbrella review aims to comprehensively synthesize the evidence of association between peripheral, electrophysiological, neuroimaging, neuropathological, other biomarkers diagnosis psychotic disorders. Study Design We selected systematic reviews meta-analyses observational studies on diagnostic for disorders, published until February 1, 2018. Data extraction was conducted according Preferred Reporting Items Systematic Meta-Analyses (PRISMA) guidelines....
Preclinical and human studies suggest that hippocampal dysfunction is a key factor in the onset of psychosis. People at Clinical High Risk for psychosis (CHR-P) present with clinical syndrome can include social withdrawal have 20–35% risk developing next 2 years. Recent research shows resting blood flow altered CHR-P individuals predicts adverse outcomes, such as non-remission/transition to frank Previous work healthy males indicates single dose intranasal oxytocin has positive effects on...
Abnormalities in functional brain networks (functional connectome) are increasingly implicated people at Clinical High Risk for Psychosis (CHR-P). Intranasal oxytocin, a potential novel treatment the CHR-P state, modulates network topology healthy individuals. However, its connectomic effects remain unknown. Forty-seven men (30 and 17 controls) received acute challenges of both intranasal oxytocin 40 IU placebo two parallel randomised, double-blind, placebo-controlled cross-over studies...
The diagnostic and prognostic significance of the DSM-5-defined Attenuated Psychosis Syndrome (DSM-5-APS) in individuals undergoing an ultra high risk (UHR) clinical assessment for suspicion psychosis is unknown.Prospective cohort study including all consecutive help-seeking both a DSM-5-APS Comprehensive Assessment At Risk Mental States (CAARMS 12/2006) at Outreach Support South London (OASIS) UHR service (March 2013-April 2014). was assessed with percent overall agreement, prevalence bias...
Social deficits are key hallmarks of the Clinical High Risk for Psychosis (CHR-P) state and established psychotic disorders, contribute to impaired social functioning, indicating a potential target interventions. However, current treatments do not significantly ameliorate impairments in CHR-P individuals. Given its critical role behaviour cognition, oxytocinergic (OT) system is promising novel interventions subjects. In double-blind, placebo-controlled, crossover design, 30 males were...
ABSTRACT Abnormalities in functional brain networks (functional connectome) are increasingly implicated people at Clinical High Risk for Psychosis (CHR-P). Intranasal oxytocin, a potential novel treatment the CHR-P state, modulates network topology healthy individuals. However, its connectomic effects remain unknown. Forty-seven men (30 and 17 controls) received acute challenges of both intranasal oxytocin 40 IU placebo two parallel randomised, double-blind, placebo-controlled cross-over...
Recent research suggests that individuals at ultra-high risk for psychosis (UHR) show altered resting cerebral blood flow (rCBF) in key regions linked to pathophysiology: the hippocampus, midbrain, and basal ganglia. Greater perturbations ganglia rCBF were correlated with positive psychotic symptoms, while remission from UHR state was associated a longitudinal normalization of hippocampal rCBF. Oxytocin -a neuropeptide potential anxiolytic prosocial properties- is currently under...
Accumulating research suggests that altered levels of neurochemical metabolites -such as glutamate- play a role in psychosis pathophysiology, are present prior to onset people at Clinical High Risk (CHR-P) and predict clinical outcomes. Oxytocin, neuropeptide with prosocial anxiolytic properties, modulates glutamate neurotransmission animals but its effects CHR-P individuals remain unknown. The study examined the intranasal oxytocin on glutamate+glutamine (primary hypothesis) other...
Abstract Background Negative symptoms are core contributors to social deficits in psychosis. However, currently available interventions do not significantly ameliorate negative or outcomes individuals at Clinical High Risk of Psychosis (CHR-P). Given its critical role human behaviour and cognition, the oxytocin (OT) system is a promising target for treatment impairments CHR-P subjects. Methods In double-blind, placebo-controlled, crossover design, 30 males were studied using functional...