Sonja M. C. de Zwarte
A5027579393- Genetic Associations and Epidemiology
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Genomic variations and chromosomal abnormalities
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Epigenetics and DNA Methylation
- Genomics and Rare Diseases
- Hemispheric Asymmetry in Neuroscience
- Fetal and Pediatric Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Mental Health Research Topics
- Bioinformatics and Genomic Networks
- Diet and metabolism studies
- Prenatal Screening and Diagnostics
- Health, Environment, Cognitive Aging
- Genetic Syndromes and Imprinting
- Neuroscience and Music Perception
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Adolescent and Pediatric Healthcare
- Axon Guidance and Neuronal Signaling
University Medical Center Utrecht
2016-2024
Utrecht University
2017-2024
Radboud University Nijmegen
2019
The University of Melbourne
2019
University of Hong Kong
2017
The two hemispheres of the human brain differ functionally and structurally. Despite over a century research, extent to which asymmetry is influenced by sex, handedness, age, genetic factors still controversial. Here we present largest ever analysis subcortical asymmetries, in harmonized multi-site study using meta-analysis methods. Volumetric seven structures was assessed 15,847 MRI scans from 52 datasets worldwide. There were sex differences globus pallidus putamen. Heritability estimates,...
Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting equivocal findings. We carried out largest case–control study structural asymmetries with MRI data from 5,080 affected individuals 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global regional cortical thickness, surface...
<h3>Importance</h3> Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) 2 (BP2) are associated with neurodevelopmental disorders. These structural variants present 0.5% to 1.0% of population, making BP1-BP2 site most prevalent known pathogenic copy number variation (CNV). It is unknown what extent this CNV influences brain structure affects cognitive abilities. <h3>Objective</h3> To determine association deletion duplication CNVs cortical...
Carriers of large recurrent copy number variants (CNVs) have a higher risk developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes 12 deletion duplication 6882 non-carriers from the large-scale Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent calling procedures, standardized FreeSurfer image analysis, we found negative dose-response associations with on...
This large multi‐center study investigates the relationships between genetic risk for schizophrenia and bipolar disorder, multi‐modal endophenotypes psychosis. The sample included 4,242 individuals; 1,087 patients with psychosis, 822 unaffected first‐degree relatives of patients, 2,333 controls. Endophenotypes P300 event‐related potential ( N = 515), lateral ventricular volume 798), cognitive measures block design 3,089), digit span 1,437), Ray Auditory Verbal Learning Task 2,406). Data were...
Schizophrenia patients show signs of accelerated aging in cognitive and physiological domains. Both schizophrenia aging, as measured by MRI brain images epigenetic clocks, are correlated with increased mortality. However, the association between these measures have not yet been studied patients. In healthy subjects, was assessed tissue using a longitudinal (N = 715 scans; mean scan interval 3.4 year) blood two age clocks 172). Differences ('gaps') estimated ages chronological were...
This review summarizes the last decade of work by ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance over 1,400 scientists across 43 countries, studying human brain in health and disease. Building on large-scale genetic studies that discovered first robustly replicated loci associated with metrics, has diversified into 50 working groups (WGs), pooling worldwide data expertise to answer fundamental questions neuroscience, psychiatry, neurology,...
Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism intellectual disability. Human display a high prevalence of micro- macrocephaly in carriers, respectively. The underlying brain structural diversity remains largely unknown. We systematically called CNVs 38 cohorts from the large-scale ENIGMA-CNV collaboration UK Biobank identified 28 22 37,088 non-carriers (48%...
The cerebral cortex underlies our complex cognitive capabilities, yet we know little about the specific genetic loci influencing human cortical structure. To identify variants, including structural impacting structure, conducted a genome-wide association meta-analysis of brain MRI data from 51,662 individuals. We analysed surface area and average thickness whole 34 regions with known functional specialisations. identified 255 nominally significant ( P ≤ 5 × 10 −8 ); 199 survived multiple...
Structural brain abnormalities and cognitive deficits have been reported in patients with schizophrenia to a lesser extent their first-degree relatives (FDRs). Here we investigated whether nonpsychotic differ per type of FDR how these are related intelligent quotient (IQ). Nine hundred eighty individuals from 5 family cohorts (330 FDRs, 432 controls, 218 patients) were included. Effect sizes calculated compare measures FDRs between each FDR. Analyses repeated correction for IQ, having...
Background/Objective. Enlarged lateral ventricle (LV) volume and decreased in the corpus callosum (CC) are hallmarks of schizophrenia (SZ). We previously showed an inverse correlation between LV CC volumes SZ, with global functioning decreasing increased volume. This study investigates relationship volume, abnormalities, microRNA MIR137 its regulated genes because MIR137's essential role neurodevelopment. Methods. Participants were 1224 SZ probands 1466 unaffected controls from GENUS...
Cross-sectional studies have shown that the polygenic risk score for schizophrenia (PRSSCZ) may influence heterogeneity in cognitive performance although evidence from family-based longitudinal study is limited. This aimed to identify trajectories of function and assess whether PRSSCZ associated with baseline predicted six-year trajectories. We included 1119 patients a spectrum disorder, 1059 unaffected siblings 586 unrelated controls who are eligible at baseline. Genotype data were...
We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around world jointly analyze 10,000+ existing MRI connectivity datasets during 3-day workshop. In this report, we describe motivation and principles of public release 8,000+ connectome maps human brain.
Abstract Background There is evidence for a polygenic contribution to psychosis. One targetable mechanism through which variation may impact on individuals and interact with the social environment stress sensitization, characterized by elevated reactivity minor stressors in daily life. The current study aimed investigate whether modified risk score schizophrenia (PRS) cases enduring non-affective psychotic disorder, first-degree relatives of cases, controls. Methods We used experience...