Je‐Yeon Yun
A5086800447- Functional Brain Connectivity Studies
- Obsessive-Compulsive Spectrum Disorders
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Autism Spectrum Disorder Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Employment and Welfare Studies
- Health disparities and outcomes
- Mental Health and Psychiatry
- Treatment of Major Depression
- Mindfulness and Compassion Interventions
- COVID-19 and Mental Health
- Healthcare professionals’ stress and burnout
- Hemispheric Asymmetry in Neuroscience
- Mental Health Treatment and Access
- Workplace Health and Well-being
- Advanced MRI Techniques and Applications
- Health, Environment, Cognitive Aging
- Botulinum Toxin and Related Neurological Disorders
- Stress Responses and Cortisol
Seoul National University
2016-2025
Seoul National University Hospital
2016-2025
New Generation University College
2025
Yuncheng University
2022
Lee University
2022
University of Basel
2020
Stellenbosch University
2020
University of Münster
2020
National University College
2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2019
A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines data from many institutions worldwide. However, introduces heterogeneity due to different scanning devices and sequences. ENIGMA projects commonly address with random-effects meta-analysis or mixed-effects mega-analysis. Here we tested whether batch adjustment method, ComBat, can further reduce site-related...
Disrupted thalamo-cortical connectivity is regarded as a core psychopathology in patients diagnosed with schizophrenia. However, whether the white matter disrupted before onset of psychosis still unknown. To determine this gap knowledge, strength anatomical subjects at clinical-high risk for (CHR) was compared to that first-episode (FEP) and healthy controls. A total 37 CHR, 21 FEP, matched controls underwent diffusion-weighted magnetic resonance imaging examine number probabilistic...
Objective: Brain imaging communities focusing on different diseases increasingly start collaborating and pooling data to perform well-powered meta- mega-analyses. Some methodologists claim that a one-stage individual-participant mega-analysis can be superior two-stage aggregated meta-analysis, since more detailed computations performed in mega-analysis. Before definitive conclusions regarding the performance of either method drawn, it is necessary critically evaluate methodology of, results...
Abstract Little is known about the relationship between levels of self-esteem and development depression in young adults. The present study investigated to determine whether are a risk factor for This was conducted with 113 college students aged 19 35 (major depressive disorder (MDD) n = 44, Mild Depressive Symptoms (MDS) 37, Healthy Control 32). clinical symptoms, self-esteem, resilience, social support, quality life, as well personality traits, were assessed (by Patient Health...
Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to common trajectories development maturation.Large-scale investigation obsessive-compulsive disorder (OCD) may provide clues the pathophysiology this neurodevelopmental disorder.Using T 1 -weighted MRI scans acquired from 1616 individuals with OCD 1463 healthy controls across 37 datasets participating ENIGMA-OCD Working Group, we calculated intra-individual (using...
Abstract Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, majority studies have focused only predefined regions or networks rather than throughout entire brain. Here, we investigated differences resting-state between OCD patients and healthy controls (HC) using mega-analysis data from 1024 1028 HC 28 independent samples ENIGMA-OCD consortium. We assessed group...
No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures cortical thickness, surface area subcortical volume tested classification performance cross-validation. Classification vs. complete sample different classifiers cross-validation strategies was...
Microstructural alterations in cortico-subcortical connections are thought to be present obsessive-compulsive disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small sample sizes provided insufficient power detect subtle abnormalities. Here we investigated microstructural white matter and their relation clinical features the largest dataset of adult pediatric OCD date. We analyzed diffusion tensor imaging metrics from 700 patients 645 controls, as...
Abstract Dysfunction of corticostriatal loops has been proposed to underlie certain cognitive and behavioral problems associated with various neuropsychiatric disorders, such as obsessive‐compulsive disorder (OCD) characterized by repetitive, unwanted thoughts, behaviors. Although functional abnormalities in the involving orbitofronto‐striato‐thalamic (OFST) circuitry patients OCD have reported, our understanding a link between disruptions architecture intrinsic network OFST circuit their...
This review summarizes the last decade of work by ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance over 1,400 scientists across 43 countries, studying human brain in health and disease. Building on large-scale genetic studies that discovered first robustly replicated loci associated with metrics, has diversified into 50 working groups (WGs), pooling worldwide data expertise to answer fundamental questions neuroscience, psychiatry, neurology,...
Previous studies on patients diagnosed with social anxiety disorder (SAD) reported changed patterns of the resting-state functional connectivity network (rs-FCN) between prefrontal cortices and other prefrontal, amygdalar or striatal regions. Using a graph theory approach, this study explored modularity-based community profile inter-/intra-modular communication for rs-FCN in SAD.In total, 28 SAD 27 healthy controls (HC), magnetic resonance imaging (fMRI) data were acquired subjected to...
Although the relationship between subjective well-being (SWB) and suicidal ideation (SI) has been illustrated in previous research, few studies have conceptualized SWB as a comprehensive measure of life satisfaction multiple domains, nor they considered possible mediators such depressive symptoms. Therefore, present study aimed to identify dimensions correlated with SI, analyze associations among sub-domains, symptoms, SI community population. A total 1200 adults South Korea, aged 20-86...
The current study examined the differential empathic capacity, post-traumatic symptoms, and coping strategies in healthcare workers (HCWs) according to exposure of verbal or physical workplace violence (WPV). Using online survey, a total 422 HCWs employed at training general hospital South Korea participated completed self-reporting questionnaires including WPV questionnaire with strategy, Jefferson Scale Physician Empathy. Those who experienced either only both had lower Empathy scores...
Background Leukotriene receptor antagonists (LTRAs) are widely used for asthma and allergic rhinitis (AR), but concerns about the risk of neuropsychiatric events (NPEs) have been raised since first Drug Safety Communication by US Food Administration in 2008. This study evaluates association between LTRA use NPEs children, adolescents young adults with or AR. Methods A self-controlled case series was conducted using Korean National Health Insurance Service claims database from two 3-year...